Binding of Isaac: Rebirth Wiki
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The 12 Signs of the Zodiac are featured as passive collectible items based on the 12 astrological signs.

Added in AfterbirthZodiac Zodiac Grants the effect of a random Zodiac sign each floor.

Added in RepentanceCollecting any three Signs of the Zodiac or Added in RepentanceCard Reading Card Reading, Crystal Ball Crystal Ball, Deck of Cards Deck of Cards, Added in RepentanceEcho Chamber Echo Chamber,Magic 8 Ball Magic 8 Ball, Added in Afterbirth †Tarot Cloth Tarot Cloth, Added in RepentanceStar of Bethlehem Star of Bethlehem and Added in AfterbirthZodiac Zodiac unlocks the Planetarium.

Items[]

Name ID Icon Quote Description Added in Repentance Quality
Aquarius 5.100.308 Aquarius Trail of tears A trail of blue creep is left behind Isaac, which damages enemies. Added in Repentance The creep inherits most of Isaac's tear effects, like homing, etc. 1
Aries 5.100.300 Aries Ramming speed +0.25 Speed. Running into enemies while at a high speed will deal damage. Removed in Repentance Does not prevent contact damage. 2
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul Hearts. Grants The Wafer The Wafer effect for the current room after taking damage. 3
Capricorn 5.100.307 Capricorn All stats up Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, Removed in Repentance +1.5 / Added in Repentance +0.75 Range, and -1.0 Tear Delay, and gives 1 Bomb, Coin, and Key. 3
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second. 1
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Libra 5.100.304 Libra You feel balanced Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes. 1
Pisces 5.100.309 Pisces Tears up + knock-back shots -1 Tear Delay, adds knock-back shots and increases tear size. 2
Sagittarius 5.100.306 Sagittarius Piercing shots + speed up Increases speed by +0.2 and grants piercing tears. 3
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted. 3
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn My Little Unicorn effect for 5 seconds. 1
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2

Unlockable Achivements[]

Trivia[]

  • Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.


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