The 12 Signs of the Zodiac are featured as passive collectible items based on the 12 astrological signs.
Zodiac Grants the effect of a random Zodiac sign each floor.
|Aquarius||5.100.308||Trail of tears||A trail of blue creep is left behind Isaac, which damages enemies.||0|
|Aries||5.100.300||Ramming speed||+0.25 Speed. Running into enemies while at a high speed will deal damage. Does not prevent contact damage.||1|
|Cancer||5.100.301||HP up + you feel protected||Adds 3 Soul Hearts. Grants The Wafer effect for the current room after taking damage.||3|
|Capricorn||5.100.307||All stats up||Increases health, damage, speed, and range, lowers tear delay, and gives one coin, bomb, and key.||3|
|Gemini||5.100.318||Conjoined friend||Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second.||1|
|Leo||5.100.302||Stompy||Isaac can destroy rocks by walking into them.||1|
|Libra||5.100.304||You feel balanced||Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.||1|
|Pisces||5.100.309||Tears up + knock-back shots||-1 Tear Delay, adds knock-back shots and increases tear size.||2|
|Sagittarius||5.100.306||Piercing shots + speed up||Increases speed by +0.2 and grants piercing tears.||3|
|Scorpio||5.100.305||Poison tears||Grants poison tears, which deal damage over time when inflicted.||2|
|Taurus||5.100.299||Speed down + rage is building||-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn effect for 5 seconds.||1|
|Virgo||5.100.303||You feel refreshed and protected||Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.||2|
- Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|