The Seven Deadly Sins are mini-bosses that can be encountered on any floor in their respective Mini-Boss rooms outside of The Chest and Dark Room. Unlike with bosses, there is no special door leading to a mini-boss room, meaning that there is no way to tell whether a room is inhabited by a mini-boss unless the player has an item that reveals map icons such as Compass or a Map item. Once in a mini-boss room, the player cannot escape through means of bombing the door, as it will be boarded off.
Each of the Sins has specific drops, that are consumables or a pedestal item (less frequently).
In a room containing multiple Sins, only the last one will drop something, allowing you to choose what drop you want by killing a certain mini-boss last.
There is an Ultra variant of both Pride and Greed. Ultra Pride resembles Edmund and Florian, while Ultra Greed serves as the final boss for Greed Mode.