|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan||Conjoined|
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
Isaac will gain 3 soul hearts and permanent flight after picking up 3 or more of the following items.
|The Bible||5.100.33||Temporary flight||On use, Isaac gains flight for the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but kills Isaac when used on Satan.||1|
|Dead Dove||5.100.185||Flight + spectral tears||Grants spectral tears and flight.||3|
|Holy Grail||5.100.184||Flight + HP up||Grants flight and one Red Heart container.||3|
|Holy Mantle||5.100.313||Holy shield||Upon entering a room, grants a shield that negates the first damage taken.||4|
|Mitre||5.100.173||Blessing of purity||Grants a chance of converting any Red Heart pickups into Soul Hearts instead.||3|
|Rosary||5.100.72||Tears + faith up||Adds 3 Soul Hearts. The Bible will appear in any item pool.
Also a +0.5 tears up.
|The Halo||5.100.101||All stats up||Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height.||2|
|Guardian Angel||5.100.112||Extra protection||Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars.||2|
|Sworn Protector||5.100.363||Protective friend||Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart.||3|
|Celtic Cross||5.100.162||Blessing of protection||Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.||1|
|Divine Intervention||5.100.568||Double tap shield||Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers.||2|
|Godhead||5.100.331||God tears||Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height.||4|
|Holy Light||5.100.374||Holy death shot||Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.||3|
|Immaculate Heart||5.100.573||Halo of tears||Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him.||3|
|Revelation||5.100.643||Awaken your faith||Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser.||4|
|Sacred Heart||5.100.182||Homing shots + DMG up||Grants homing tears, x2.3 damage multiplier, +1 flat damage, +4.125 range, +0.75 tear height, -0.4 tears, -0.25 shot speed, a red Heart Container and replenishes all Red Hearts.||4|
|Sacred Orb||5.100.691||Destined for greatness||Prevents low-quality items from spawning, greatly increasing the quality of items received from all item pools.||4|
|Salvation||5.100.696||Divine protection||Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor.||2|
|Scapular||5.100.142||Pray for a miracle||Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.||2|
- Despite having the same name, the familiar Seraphim does not contribute to the Seraphim transformation.
PC QYTQ 9MY6 First two floors
PC 6NKO NW3F (Cellar II boss. Needs to have Guppy's Tail from Curse room on 1st floor to get red chest. Rosary in Treasure room on 1st floor, The Bible from red chest on 2nd floor, The Halo from 2nd boss.)
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|