Binding of Isaac: Rebirth Wiki

Scorpio is a passive Zodiac item.


  • Grants poison tears, dealing damage over time when inflicted.
  • Removed in Afterbirth The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
  • Added in Afterbirth The poison hits twice, dealing a total of double Isaac's damage.


  • This item has the same effect as The Common Cold The Common Cold on every shot. As such, all synergies with that item also apply to Scorpio at a 100% chance.

In-game Footage[]


PC Z964 6CPS (Treasure Room adjacent to spawn)

PC MSZ6 S9KW (First floor Treasure Room)

PC Added in Afterbirth † Normal and hard modes only SQ9B YGBH (Treasure Room adjacent to spawn)

PC Added in Repentance EM9X JH2Y (tresure room adjacent to spawn)

Vita MA1Z AW7C

3DS AGVH 4AKZ (First floor Treasure Room)

Switch Greedier mode only 8M8L JCDG (First Golden Treasure Room)