Scissors

Scissors is an unlockable activated item.

Effect[]

Detaches Isaac's head from his body and turns the head into a stationary familiar that fires tears for the current room.
- The player still controls Isaac's headless body, which also shoots tears.
  - The body constantly spews a controllable fountain of blood shots, dealing about 0.66x-1.01x damage.
- The tears fired by the head do not scale with Isaac's damage and always do 3.5 damage.
  - The head's tears are affected by Isaac's stats and attack modifiers.

Can spawn multiple heads if used in the same room more than once.
- Only the most recent head is able to fire.
Brimstone and Technology are not fired from the stationary head.
If Isaac has an invisible body due to the cosmetic effect of Transcendence, only a shadow will be seen after using the Scissors.
If Isaac is Blindfolded, the floating head can still fire tears.
- Does not work with Tainted Forgotten
Each wave of Boss Rush fully recharges the item, allowing many heads to be spawned.
Only deaths which end runs (i.e. Isaac is not revived by a revival item such as 1up!) count towards unlocking the Scissors.

BFFS!: The loose head won't become larger, but will deal double damage.
Book of Virtues: Spawns red wisps in the middle ring. The wisps fire 2-3 tears at a time, which are inaccurate, travel in an arc, and have variable range.
Box of Friends: No effect.
Car Battery: No effect.

This item is very likely a reference to the English idiom "running with scissors", which means to "willfully act in a reckless, foolish, and/or dangerous manner", alluding to the literal act of running with a pair of scissors in one's hand, which can cause severe injury, thus the item's effect and unlock condition.
In original flash version of The Binding of Isaac, dying 100 times unlocked The Pinking Shears.