Sanguine Bond is an unlockable passive item added in The Binding of Isaac: Repentance.
Effects[]
- Spawns a special set of spikes in the
Devil Room. They deal 1 full heart of damage per use. - Taking damage from the spikes has a chance to grant a reward.
Rewards[]
| Chance | Reward |
|---|---|
| 35% | Nothing |
| 33% | Add .5 damage |
| 15% | 6 pennies |
| 10% | 2 Black Hearts |
| 5% | A random Devil Room item |
| 2% | Transform into Leviathan |
Notes[]
- The spikes will not appear if the current floor's Devil Room was entered before picking up Sanguine Bond.
- The spikes will deal damage to enemies that walk or fly over them, including Krampus.
Synergies[]
- Goat Head + Scapular: The spikes generated by Sanguine Bond can be farmed infinitely.
- Keeper / Tainted Keeper / Strawman: The pennies that are spawned when stepping on the spikes can be used to heal Keeper and infinitely farm rewards.
- Placenta: With a lot of time, the spikes can be farmed infinitely.
- Portable Slot: The pennies that are spawned can be gambled to give hearts, allowing more uses.
- The Wafer / Percs: Hearts will last twice as long, allowing more uses. Further uses may be obtained by sacrificing the black hearts given, and any hearts added from devil room items.
In-game footage[]
Trivia[]
- This is possibly a reference to the card of the same name from Magic: the Gathering card game.
Seeds[]
PC 
FY11 XGL4 (Curse Room adjacent to spawn)
 Tainted Judas Unlocks
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 The Beast Unlocks
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 The Binding of Isaac: Rebirth
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