Binding of Isaac: Rebirth Wiki

Added in Repentance

Sanguine Bond is an unlockable passive item added in The Binding of Isaac: Repentance.


  • Spawns a special set of spikes in the Devil Room Devil Room. They deal 1 full heart of damage per use.
  • Taking damage from the spikes has a chance to grant a reward.


Chance Reward
35% Nothing
33% + 0.5 damage
15% 6 pennies
10% 2 Black Heart Black Hearts
5% A random Devil Room item
2% Transform into Leviathan Leviathan


  • The spikes will not appear if the current floor's Devil Room Devil Room was entered before picking up Sanguine Bond.
  • The spikes will deal damage to enemies that walk or fly over them, including Krampus Krampus.


  • Goat Head Goat Head + Scapular Scapular: The spikes generated by Sanguine Bond can be farmed infinitely.
    • Quitting and reloading the game will also reset the soul heart regeneration provided by Scapular Scapular, thus negating the need for Goat Head Goat Head
  • Keeper Keeper / Tainted Keeper Tainted Keeper / Strawman Strawman: The pennies that are spawned when stepping on the spikes can be used to heal Keeper and infinitely farm rewards.
  • Placenta Placenta: With a lot of time, the spikes can be farmed infinitely.
  • Portable Slot Portable Slot: The pennies that are spawned can be gambled to give hearts, allowing more uses.
  • The Wafer The Wafer / Percs: Hearts will last twice as long, allowing more uses. Further uses may be obtained by sacrificing the black hearts given, and any hearts added from devil room items.

In-game footage[]



PC Hard mode only FY11 XGL4 (Curse Room adjacent to spawn)