Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Sanguine Bond is a passive item added in The Binding of Isaac: Repentance.


  • Spawns a special set of spikes in the Devil Room Devil Room. They deal 1 full heart of damage per use.
  • Taking damage from the spikes has a chance to grant a reward.


Chance Reward
42% Nothing
35% 6 pennies
15% Add .5 damage
5% 2 Black Hearts
2% A random item
1% Transform into Leviathan


  • The spikes will not appear if the current floor's Devil Room Devil Room was entered before picking up Sanguine Bond.
  • The spikes will deal damage to enemies that walk or fly over them, including Krampus.


  • Goat Head Goat Head + Scapular Scapular: The spikes generated by Sanguine Bond can be farmed infinitely.
    • Quitting and reloading the game will also reset the soul heart regeneration provided by Scapular Scapular, thus negating the need for Goat Head Goat Head
  • Keeper Keeper / Tainted Keeper Tainted Keeper / Strawman Strawman: The pennies that are spawned when stepping on the spikes can be used to heal Keeper and infinitely farm rewards.

In-game footage[]



PC Hard mode only FY11 XGL4 (Curse Room adjacent to spawn)