Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Samson is unlocked when the player defeats two floors in a row without taking any damage. Samson starts with 3 Red Heart containers and 15►Bloody Lust Bloody Lust. Every time Samson is dealt damage, he receives a damage boost that resets when he goes down a floor.

Added in Afterbirth † Samson will start with the Child's Heart Child's Heart trinket after completing the Ultra Hard challenge.


  • Samson gains damage from being hurt, and as such, possesses a playstyle that is fairly similar to Eve Eve. Therefore, using Devil beggars, Sacrifice Rooms and Blood Donation Machines synergizes very well with Samson.
  • Samson starts with a lower Tear stat. Try to seek items that increase it.
  • Dying as Samson and then respawning as another character (15►Lazarus' Rags Lazarus' Rags, 15►Ankh Ankh, etc.) won't cost you and will allow you to inherit Samson's15►Bloody Lust Bloody Lust item.
  • When Samson dies in Co-Op mode, his ghost baby maintains his level of rage from his Bloody Lust item, giving it a red tint. This is purely cosmetic.

Item Interactions[]

  • Added in Repentance15►Birthright Birthright: 15►Bloody Lust Bloody Lust can gain 4 more damage boosts at the same +0.2 intervals, for a new maximum total of +14.0.

Favorable items[]

  • Any items that increase health so he can take more damage before dying.
  • Any items that increase Samson's tear stat, such as 15►Squeezy Squeezy, 15►Odd Mushroom Odd Mushroom...
  • Any items that generate Blue Flies like 15►Rotten Baby Rotten Baby or 15►Guppy's Head Guppy's Head do so based on Samson's base damage and are good for early game room clearing when Samson's tears are still low.
  • Items relying on contact damage like 15►The Virus The Virus or 15►E Coli E Coli can be beneficial in that you "want" to take damage because of 15►Bloody Lust Bloody Lust.
  • Health regeneration items like 15►Yum Heart Yum Heart, 15►Pyromaniac Pyromaniac, and 15►Placenta Placenta allow health regeneration after taking damage, and thus allow for more damage, both stat-wise and health-wise.
  • 15►Cancer Cancer and 15►The Wafer The Wafer minimize damage taken from Sacrifice Rooms and can be incredibly useful to build a lot of damage and pickups, especially in combination with an excess of hearts.
  • 15►Dead Bird Dead Bird, 15►Best Bud Best Bud, 15►Smart Fly Smart Fly, etc: All of these items will add to Samson's damage increase from getting hurt, although, unlike Bloody Lust, the bonus of these items only last for the duration of a room.
  • 15►Fanny Pack Fanny Pack's chance of dropping a heart upon hit can cancel out damage to Samson while also buffing him.
  • Added in Afterbirth †15►Dull Razor Dull Razor can safely provide Samson's damage boost without needing to take damage.
  • 15►Gimpy Gimpy increases benefits from taking damage and feasibly adds more survivability from random soul hearts and half-heart drops.
  • Added in Afterbirth15►Immaculate Conception Immaculate Conception and Added in Afterbirth15►Cambion Conception Cambion Conception will produce familiars as Samson heals or receives damage, respectively.
  • 15►IV Bag IV Bag, 15►Blood Rights Blood Rights, 15►Razor Blade Razor Blade, 15►Sharp Plug Sharp Plug, 15►Kamikaze! Kamikaze!: Activating their effects also give Samson a boost in damage since they damage the player.
  • Added in Repentance15►Blood Oath Blood Oath is extremely useful on Samson, as its damage up effect stacks with 15►Bloody Lust Bloody Lust, meaning you will start every floor with a significant amount of damage up.

Unfavorable items[]

  • Anything which lowers health such as 15►Dead Cat Dead Cat can make purposeful self-damage less reliable as a damage booster.
  • Tears down Pills are especially bad due to his low starting Tears stat

Unlockable Achievements[]


  • In the Bible, Samson was a supernaturally strong warrior who derived his power from his Nazarite vow, entitling immense strength to Samson if he did not cut his hair.
  • Samson first appeared in the Binding of Isaac: Wrath of the Lamb expansion. That version had only 1 heart container and a soul heart for his starting health, and his Bloody Lust item acted like the Added in Afterbirth15►Lusty Blood Lusty Blood item, re-added in Afterbirth, though much weaker.
    • Samson was originally unlocked by skipping two Treasure Room items and killing Mom in one run.



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Tainted Isaac CharNav New.png Tainted Maggy CharNav New.png Tainted Cain CharNav New.png Tainted Judas CharNav New.png Tainted BB CharNav New.png Tainted Eve CharNav New.png Tainted Samson CharNav New.png Tainted Azazel CharNav New.png Tainted Lazarus CharNav New.png Tainted Eden CharNav New.png Tainted Lost CharNav New.png Tainted Lilith CharNav New.png Tainted Keeper CharNav New.png Tainted Apollyon CharNav New.png Tainted Forgotten CharNav New.png Tainted Bethany CharNav New.png Tainted Jacob CharNav New.png

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