Binding of Isaac: Rebirth Wiki

Samson is unlocked when the player defeats two floors in a row without taking any damage. Samson starts with 3 Red Heart containers and Bloody Lust Bloody Lust. Every time Samson is dealt damage, he receives a damage boost that resets when he goes down a floor.

Added in Afterbirth † Samson will start with the Child's Heart Child's Heart trinket after completing the Ultra Hard challenge.


  • Samson gains damage from being hurt, and as such, possesses a playstyle that is fairly similar to Eve Eve. Therefore, using Devil Beggar.png Devil Beggars, Sacrifice Room Sacrifice Rooms and Blood Donation Machine.png Blood Donation Machines synergizes very well with Samson.
  • Samson starts with a lower Tear stat. Try to seek items that increase it.
  • Dying as Samson and then respawning as another character (Lazarus' Rags Lazarus' Rags, Ankh Ankh, etc.) won't cost you and will allow you to inherit Samson's Bloody Lust Bloody Lust item.
  • When Samson dies in Co-Op mode, his ghost baby maintains his level of rage from his Bloody Lust item, giving it a red tint. This is purely cosmetic.

Item Interactions[]

  • Added in RepentanceBirthright Birthright: Bloody Lust Bloody Lust can gain 4 more damage boosts at the same +0.2 intervals, for a new maximum total of +14.0.

Favorable items[]

  • Any items that increase health so Samson can take more damage before dying.
  • Any items that increase Samson's tear stat, such as Squeezy Squeezy, Odd Mushroom Odd Mushroom...
  • Any items that generate Blue Flies like Rotten Baby Rotten Baby or Guppy's Head Guppy's Head do so based on Samson's base damage and are good for early game room clearing when Samson's tears are still low.
  • Items relying on contact damage like The Virus The Virus or E. Coli E. Coli can be beneficial in that you "want" to take damage because of Bloody Lust Bloody Lust.
  • Health regeneration items like Yum Heart Yum Heart, Pyromaniac Pyromaniac, and Placenta Placenta allow health regeneration after taking damage, and thus allow for more damage, both stat-wise and health-wise.
  • Cancer Cancer and The Wafer The Wafer minimize damage taken from Sacrifice Rooms and can be incredibly useful to build a lot of damage and pickups, especially in combination with an excess of hearts. The Wafer in particular is incredibly helpful in Chapter 4 and beyond, where all taken damage increases to one full heart per instance.
  • Dead Bird Dead Bird, Best Bud Best Bud, Smart Fly Smart Fly, etc: All of these items will add to Samson's damage increase from getting hurt, although, unlike Bloody Lust, the bonus of these items only last for the duration of a room.
  • Fanny Pack Fanny Pack's chance of dropping a heart upon hit can cancel out damage to Samson while also buffing him.
  • Added in Afterbirth †Dull Razor Dull Razor can safely provide Samson's damage boost without needing to take damage.
  • Gimpy Gimpy increases benefits from taking damage and feasibly adds more survivability from random soul hearts and half-heart drops.
  • Added in AfterbirthImmaculate Conception Immaculate Conception and Added in AfterbirthCambion Conception Cambion Conception will produce familiars as Samson heals or receives damage, respectively.
  • IV Bag IV Bag, Blood Rights Blood Rights, Razor Blade Razor Blade, Sharp Plug Sharp Plug, Kamikaze! Kamikaze!: Activating their effects also give Samson a boost in damage since they damage the player.
  • Added in RepentanceBlood Oath Blood Oath is extremely useful on Samson, as its damage up effect stacks with Bloody Lust Bloody Lust, meaning you will start every floor with a significant amount of damage up.

Unfavorable items[]

  • Anything which lowers health such as Dead Cat Dead Cat can make purposeful self-damage less reliable as a damage booster. For this reason, taking items from the Devil Room Devil Room or the Black Market Black Market, which cost health for every item thus taken, is not recommended for Samson.
  • Tears Down Pills are especially bad for Samson due to his low starting Tears stat.

Unlockable Achievements[]


  • In the Bible, Samson was a supernaturally strong warrior who derived his power from his Nazarite vow, entitling immense strength to Samson if he did not cut his hair.
  • Samson first appeared in the Binding of Isaac: Wrath of the Lamb expansion. That version had only 1 heart container and a soul heart for his starting health, and his Bloody Lust item acted like a weaker version of Afterbirth's Added in AfterbirthLusty Blood Lusty Blood item.
    • Samson was originally unlocked by skipping two Treasure Room items and killing Mom Mom in one run.
  • Samson's locked icon shows him bound in chains.