This item belongs to the Seraphim set. Collecting three items from this set will transform Isaac into an angel.
Dice Bag: The one-time-use dice given byt his trinket are not affected.
Lemegeton: Generated items are affected by Sacred Orb.
Modeling Clay: Temporary items generated by this trinket are affected by Sacred Orb.
Sacred Orb: The chance of quality 2 items being rerolled does not increase and multiple copies of the item don't provide a benefit.
Due to being quality 0,Skatole cannot be obtained from Shell Games after Sacred Orb has been picked up.
The design of the Sacred Orb seems to be based upon a globus cruciger, lit. "cross-bearing orb", a Christian symbol of authority.
This item is a stronger version of the mechanics of Tainted Lost. Its unlock method is unusual, as most other tainted characters have items based on their mechanics unlocked by defeating Delirium instead of The Beast.