- Prevents low-quality items from spawning, greatly increasing the quality of items received from all item pools.
- Items with a quality of 0-1 are automatically rerolled.
- Items with a quality of 2 have a 33% chance to be automatically rerolled.
- Due to being quality 0, Skatole cannot be obtained from Shell Games after Sacred Orb has been picked up.
- The design of the Sacred Orb seems to be based upon a globus cruciger, lit. "cross-bearing orb", a Christian symbol of authority.
- This item is a stronger version of the mechanics of Tainted Lost. Its unlock method is unusual, as most other tainted characters have items based on their mechanics unlocked by defeating Delirium instead of The Beast.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|