Binding of Isaac: Rebirth Wiki

(except in Rebirth)

Rune Bag is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects[ | ]

  • Spawns a familiar that drops a random rune after clearing enough rooms.
    • (except in Repentance) Runes are dropped alternating every 5 or 6 rooms.
    • (in Repentance) Runes are dropped alternating every 7 or 8 rooms.

Notes[ | ]

  • (except in Repentance) If there are no runes unlocked, it will drop cards instead.
  • (in Repentance) Rune Bag will also drop Soul Stones if any have been unlocked.
  • (in Repentance) If less than 6 runes are unlocked, it can drop a Rune ShardRune Shard instead of a rune.
  • (in Repentance) Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Rune Bag having the lowest priority at 6th and thus being farther from Isaac than familiars of different priorities.

Synergies[ | ]

  • Collectible BFFS! iconBFFS!: The drop rate is improved to every 4-5 rooms.
    • (in Repentance) The drop rate is improved to every 6 rooms.

In-game Footage[ | ]

Trivia[ | ]

This item is the rune counterpart to Collectible Bomb Bag iconBomb Bag, Collectible Mystery Sack iconMystery Sack, Collectible Sack of Pennies iconSack of Pennies, and (in Afterbirth † and Repentance)Collectible Sack of Sacks iconSack of Sacks.

Bugs[ | ]

Bug Bug! If one half of Character Tainted Lazarus iconTainted Lazarus holds this item, the Rune Bag will always drop the same rune for the whole run.