Upon entering a Devil Room, a white inverted cross will appear above Isaac's head. If Isaac goes to the next floor with the icon still above his head, he will gain a Soul Heart and +1.0 damage.
Taking anything generated by the room (items or consumables) will result in the icon going away, including opening Red Chests/ Black Sacks.
Notes[]
If there is an item in a Red Chest, the icon will not disappear, even if the item is taken.
Opening Red Chests that have been spawned after room generation, e.g. as a room clear reward or enemy drop, or opening them with Magneto, won't remove the icon.
After Isaac has taken a Devil Deal, while a Confessional or Sacrifice Room would give an Angel Room item, it has a higher chance to spawn Redemption instead. This is the only way Redemption can be naturally generated during a run.
Taking items spawned from Magic Skin inside the Devil Room will not remove the cross.
Interactions[]
Devil's Crown: Devil Treasure Rooms will count as regular Devil Rooms for the purposes of this item.
Jacob and Esau: The cross will only disappear if the character holding Redemption takes something. The other character is free to take items and pickups.
Satanic Bible: Taking a Boss item that was replaced with a Devil Deal will remove the cross, however the Boss Room doesn't give the cross.
Tainted Lazarus: Redemption will only activate if the character holding it is the one that enters the Devil room, and will only grant the benefit if the character holding it travels to the next floor. It will not work when transforming inside.
In-game footage[]
Trivia[]
The pickup quote is taken from the last verse of the Lord's Prayer: "And lead us not into temptation, but deliver us from evil.'"
Devil Room, a white inverted cross will appear above Isaac's head. If Isaac goes to the next floor with the icon still above his head, he will gain a 
Judas Unlocks 
The Beast Unlocks 
The Binding of Isaac: Rebirth
