Binding of Isaac: Rebirth Wiki

Items in this pool can be found in Red ChestRed Chests.

Activated Collectibles[ | ]

Name ID Icon Weight Description
Guppy's Head 5.100.145
Guppy's Head
1 room
Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw 5.100.133
Guppy's Paw
Upon use, converts one Red Heart Container into three Soul HeartSoul Hearts.
Pandora's Box 5.100.297
Pandora's Box
One time use
Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.
(in Afterbirth † and Repentance) Plan C 5.100.475
Plan C
One time use
(except in Repentance)0.2
(in Repentance)0.1
Kills all enemies in the room, then kills Isaac three seconds later.
(in Repentance) Magic Skin 5.100.642
Magic Skin
6 rooms
Consumes one heart container or two Soul HeartSoul Hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items.
(in Repentance) Red Key 5.100.580
Red Key
4 rooms
Creates a Red RoomRed Room adjacent to a viable wall, indicated by the outline of a door. These rooms have a 10% chance to be a special room.

Passive Collectibles[ | ]

Name ID Icon Weight Description
Dead Cat 5.100.81 Dead Cat
Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Guppy's Collar 5.100.212 Guppy's Collar
Grants a permanent 50% chance to respawn with 1/2 of a Red HeartRed Heart after death.
Guppy's Tail 5.100.134 Guppy's Tail
Room Clear Awards have a 1/3 chance of being replaced with a ChestChest and a 2/9 chance being replaced with nothing.
(in Rebirth) Goat Head 5.100.215 Goat Head
A Devil RoomDevil Room / Angel RoomAngel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4.
(except in Rebirth) Bob's Curse 5.100.140 Bob's Curse
+5 BombBombs. Grants Isaac's bombs a poison effect. (in Repentance) They also leave a lingering poison cloud, and Isaac becomes immune to poison.
(except in Rebirth) Curse of the Tower 5.100.371 Curse of the Tower
Upon taking damage, spawns six Troll BombTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower.
(except in Rebirth) Cursed Eye 5.100.316 Cursed Eye
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
(in Repentance) Guppy's Eye 5.100.665 Guppy's Eye
Shows the contents of ChestChests, Fire PlaceFire Places, Grab BagGrab Bags, and ShopkeeperShopkeepers before they're opened/destroyed.
(in Repentance) Blood Puppy 5.100.565 Blood Puppy
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red HeartHalf Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal.
(in Repentance) False PHD 5.100.654 False PHD
Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black HeartBlack Heart.