Binding of Isaac: Rebirth Wiki

Items in this pool can be found in Red Chest Red Chests.

Activated Collectibles[]

Name ID Icon Weight Description
Guppy's Head 5.100.145
Guppy's Head
1 rooms
Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw 5.100.133
Guppy's Paw
Upon use, converts one Red Heart Container into three Soul Heart Soul Hearts.
Pandora's Box 5.100.297
Pandora's Box
One time use
Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.
Added in Afterbirth † Plan C 5.100.475
Plan C
One time use
Removed in Repentance0.2
Added in Repentance0.1
Kills all enemies in the room, then kills Isaac three seconds later.
Added in Repentance Magic Skin 5.100.642
Magic Skin
6 rooms
Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items.
Added in Repentance Red Key 5.100.580
Red Key
4 rooms
Creates a Red Room Red Room adjacent to a viable wall, indicated by the outline of a door. These rooms have a 10% chance to be a special room.

Passive Collectibles[]

Name ID Icon Weight Description
Dead Cat 5.100.81 Dead Cat
Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Guppy's Collar 5.100.212 Guppy's Collar
Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Tail 5.100.134 Guppy's Tail
Room Clear Awards have a 1/3 chance of being replaced with a Chest and a 1/3 chance being replaced with nothing.
Removed in Afterbirth Goat Head 5.100.215 Goat Head
A Devil Room Devil Room / Angel Room Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4.
Added in Afterbirth Bob's Curse 5.100.140 Bob's Curse
Gives 5 bombs and grants Isaac's bombs a poison effect. Added in Repentance Gives Isaac immunity to poison.
Added in Afterbirth Curse of the Tower 5.100.371 Curse of the Tower
Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower.
Added in Afterbirth Cursed Eye 5.100.316 Cursed Eye
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Added in Repentance Guppy's Eye 5.100.665 Guppy's Eye
Shows the contents of Chest Chests, Fire Place Fire Places, Added in Afterbirth Grab Bag Sacks, and Shopkeeper Shopkeepers before they're opened/destroyed.
Added in Repentance Blood Puppy 5.100.565 Blood Puppy
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal.
Added in Repentance False PHD 5.100.654 False PHD
Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart Black Heart.