Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Polycephalus is a boss that can appear:


Polycephalus burrows underground when Isaac is not within range. While burrowed he becomes invincible and follows Isaac's movements. When close to Isaac, he pops out and performs one of the following attacks:

  • Sprays out a cluster of projectiles towards Isaac, similar to Monstro, but more drawn out.
  • Fires a spread of 3 projectiles at Isaac.
  • Shoots out 8 projectiles in all directions.
  • Summons a Round Worm.

He will stay vulnerable for a few moments after performing an attack before quickly burrowing underground again.

Champion Versions Needs to be unlocked[]

  • Added in Afterbirth Red: Summons Para-Bites instead of Round Worms. All projectile attacks are replaced with a ring of six projectiles.
  • Added in Afterbirth Pink: Two Polycephaluses, each with 50% HP (100), replace the normal Polycephalus. They do not spawn Round Worms.



  • Added in Afterbirth The Stain is his posthumous version, who also shows up in Chapter 2. Polycephalus is one of four bosses to have their posthumous version in the same chapter, the others being Gemini having Blighted Ovum in Chapter 1, Chub having Carrion Queen in Chapter 2 and Tuff Twins having The Shell in Chapter 2.5.
    • Removed in Repentance However, Polycephalus is the only one of them to have their posthumous version in the same environments as well, sharing both The Catacombs and the Added in Afterbirth Flooded Caves Flooded Caves with The Stain. The only difference is that The Stain can appear in Caves Caves as well, where Polycephalus cannot.
      • Added in Repentance This is no longer the case as of Repentance, since Polycephalus no longer appears in the Flooded Caves while The Stain no longer appears in The Catacombs.
  • Polycephaly is the condition of having more than one head.
  • Polycephalus shares his name with a cactus.
  • Polycephalus is one of the four bosses that can be spawned by It Lives, the other three being Chub, Added in RepentanceFistula and Teratoma.
  • Added in Afterbirth † Prior to Booster Pack #5, Red Champion Polycephalus could spawn Scarred Para-Bites if he was fought in the Added in Afterbirth Scarred Womb Scarred Womb.

Bosses Boss Monstro.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
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The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
Chapter 6
Stage Dark Room icon.pngStage Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
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