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Polycephalus is a boss that can appear:

Behavior[ | ]

Polycephalus burrows underground when Isaac is not within range. While burrowed he becomes invincible and follows Isaac's movements. When close to Isaac, he pops out and performs one of the following attacks:

  • Sprays out a cluster of projectiles towards Isaac, similar to Boss Monstro ingameMonstro, but more drawn out.
  • Fires a spread of 3 projectiles at Isaac.
  • Shoots out 8 projectiles in all directions.
  • Summons a Round WormRound Worm.

He will stay vulnerable for a few moments after performing an attack before quickly burrowing underground again.

Champion Versions Needs to be unlocked[ | ]

(except in Rebirth) Red: Summons Para-BitePara-Bites instead of Round Worms. All projectile attacks are replaced with a ring of six projectiles.
(except in Rebirth) Pink: Two Polycephaluses, each with 50% HP (100), replace the normal Polycephalus. They do not spawn Round Worms.

Gallery[ | ]

Trivia[ | ]

  • (except in Rebirth) Boss The Stain ingameThe Stain is his posthumous version, who also shows up in Chapter 2. Polycephalus is one of four bosses to have their posthumous version in the same chapter, the others being Boss Gemini ingameGemini having Boss Blighted Ovum ingameBlighted Ovum in Chapter 1, Boss Chub ingameChub having Boss Carrion Queen ingameCarrion Queen in Chapter 2 and the (in Repentance) Boss Tuff Twins ingameTuff Twins having (in Repentance) Boss The Shell ingameThe Shell in Chapter 2.5.
    • (except in Repentance) However, Polycephalus is the only one of them to have their posthumous version in the same environments as well, sharing both the CatacombsCatacombs and the (except in Rebirth)Flooded CavesFlooded Caves with The Stain. The only difference is that The Stain can appear in CavesCaves as well, where Polycephalus cannot.
      • (in Repentance) This is no longer the case as of Repentance, since Polycephalus no longer appears in the Flooded Caves while The Stain no longer appears in The Catacombs.
  • Polycephaly is the condition of having more than one head.
  • Polycephalus shares his name with a cactus.
  • Polycephalus is one of the four bosses that can be spawned by Boss It Lives ingameIt Lives, the other three being Chub, (in Repentance) Boss Fistula ingameFistula and Boss Teratoma ingameTeratoma.
  • (in Afterbirth † and Repentance) Prior to Booster Pack #5, Red Champion Polycephalus could spawn Scarred Para-BiteScarred Para-Bites if he was fought in the Scarred WombScarred Womb.


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