Binding of Isaac: Rebirth Wiki

Polycephalus is a boss that can appear:


Polycephalus burrows underground when Isaac is not within range. While burrowed he becomes invincible and follows Isaac's movements. When close to Isaac, he pops out and performs one of the following attacks:

  • Sprays out a cluster of projectiles towards Isaac, similar to Monstro Monstro, but more drawn out.
  • Fires a spread of 3 projectiles at Isaac.
  • Shoots out 8 projectiles in all directions.
  • Summons a Round Worm Round Worm.

He will stay vulnerable for a few moments after performing an attack before quickly burrowing underground again.

Champion Versions Needs to be unlocked[]

Added in Afterbirth Red: Summons Para-Bite Para-Bites instead of Round Worms. All projectile attacks are replaced with a ring of six projectiles.
Added in Afterbirth Pink: Two Polycephaluses, each with 50% HP (100), replace the normal Polycephalus. They do not spawn Round Worms.



  • Added in Afterbirth The Stain The Stain is his posthumous version, who also shows up in Chapter 2. Polycephalus is one of four bosses to have their posthumous version in the same chapter, the others being Gemini Gemini having Blighted Ovum Blighted Ovum in Chapter 1, Chub Chub having Carrion Queen Carrion Queen in Chapter 2 and the Added in Repentance Tuff Twins Tuff Twins having Added in Repentance The Shell The Shell in Chapter 2.5.
    • Removed in Repentance However, Polycephalus is the only one of them to have their posthumous version in the same environments as well, sharing both The Catacombs and the Added in Afterbirth Flooded Caves Flooded Caves with The Stain. The only difference is that The Stain can appear in Caves Caves as well, where Polycephalus cannot.
      • Added in Repentance This is no longer the case as of Repentance, since Polycephalus no longer appears in the Flooded Caves while The Stain no longer appears in The Catacombs.
  • Polycephaly is the condition of having more than one head.
  • Polycephalus shares his name with a cactus.
  • Polycephalus is one of the four bosses that can be spawned by It Lives It Lives, the other three being Chub, Added in Repentance Fistula Fistula and Teratoma Teratoma.
  • Added in Afterbirth † Prior to Booster Pack #5, Red Champion Polycephalus could spawn Added in Afterbirth Scarred Para-Bite Scarred Para-Bites if he was fought in the Added in Afterbirth Scarred Womb Scarred Womb.