Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Plan C is an unlockable activated item added in The Binding of Isaac: Afterbirth †.


  • Upon use, deals 9,999,999 damage to every enemy in the room, then kills Isaac 3 seconds later.


  • Plan C does not kill both phases of bosses like The Lamb The Lamb, Hush Hush, Ultra Greed Ultra Greed, Mega Satan Mega Satan, and Added in Repentance Mother Mother, and is most useful when used during the last phase of these multi-phase bosses.
  • For the game's sake, a run is not truly over until Isaac's Last Will appears. This means that some bosses that might seem to finish their death animations after Isaac dies, such as Removed in RepentanceUltra Greed, will still be technically killed and will still give their completion marks, even if Isaac does not enter the Final Boss Chest.
  • Some bosses have special interactions with this item:
    • Attempting to use this item to kill Delirium Delirium will not work. Its death animation is much longer than the time between using Plan C and Isaac's Last Will appearing, meaning Isaac will die first and it will not count as a kill. Having extra lives that revive Isaac outside the room will not help, either; Delirium must be fought again.
      • However, items that revive Isaac in the same room he died in, namely Lazarus' Rags Lazarus' Rags (or being Lazarus Lazarus), Added in RepentanceInner Child Inner Child, Added in RepentanceSoul of Lazarus Soul of Lazarus, and Tainted Lost Tainted Lost's Added in RepentanceBirthright Birthright, will allow Isaac to bypass this and kill Delirium with this item. In the case of Lazarus' Rags, though, the completion mark will go toward Lazarus and not the character originally selected.
        • Similarly, if playing as Tainted Lazarus Tainted Lazarus, using Plan C and then using Added in RepentanceFlip Flip to switch to the other form pauses the death counter until the player switches back to the form that originally used the item.
      • It is possible to kill Delirium by carefully timing pauses after each screen static. Each screen static plays a cutscene that continues to play even while paused, so by pausing and unpausing at the right timings, Delirium's death animation can be shortened to just under 3 seconds allowing for his completion mark to be awarded.
    • Added in Repentance Will not work if used against Ultra Greedier Ultra Greedier as Tainted Forgotten Tainted Forgotten, The Lost The Lost, Tainted Lost Tainted Lost, or Tainted Jacob Tainted Jacob in his lost form.
    • Added in Repentance Killing Mother Mother's second phase with Plan C will kill Isaac just at the end of her death animation. No completion mark is awarded.
    • Added in Repentance If used in The Beast The Beast battle, Plan C will only kill the harbinger that Isaac is fighting on screen. It won't have any effect on the other harbingers nor The Beast itself (The Beast can still be killed if Isaac is fighting it when Plan C is used, and there is enough time to earn the completion mark).
  • Invulnerable enemies and closed Host Hosts will not be killed by Plan C.
  • Isaac's last will shows his last damage source as the cause of death, not Plan C. If Isaac has not taken damage or lost health from any source, Isaac's face is shown.
  • Invincibility or the Holy Mantle Holy Mantle shield will not save Isaac from being killed.
  • Some items that activate when Isaac reaches zero hearts, such as Added in RepentanceHeartbreak Heartbreak and Added in RepentanceSpirit Shackles Spirit Shackles, will not activate and save Isaac.
  • Even if Isaac enters a trapdoor immediately after using Plan C, he will still die after arriving at the next floor.
  • Plan C has an 80% decreased item pool weight, making it less likely to appear than other collectibles.
  • Plan C is found in 8 item pools, the second highest count amongst all items, behind Cube of Meat Cube of Meat. Its lowered weight, however, offsets its presence.


  • Added in RepentanceBook of Virtues Book of Virtues: Spawns 8 red wisps that shoot red tears at 12 damage per tear. Using Plan C will kill Isaac as expected, but wisps won't disappear if used with an item that grants an extra life.

In-game Footage[]


  • This item is a reference to abortion pills, which are commonly given the nickname "Plan C." ("Plan A" being typical birth control methods, and "Plan B" being the so-called "morning-after pill," which prevents pregnancy in cases where contraception has failed.) The item's mechanic is a reference to abortion terminating an unborn fetus.
  • Plan C's sprite is a red-tinted Forget Me Now Forget Me Now.
  • In Afterbirth+, the pickup quote for the item was "Use with caution."