Plan C does not kill both phases of bosses like The Lamb, however, you will not be able to reach the chest or next floor in time. The kill still counts as a vict extra lives the run would still end.
While using this will technically kill Delirium and Mother, their death animations take longer than 3 seconds, meaning you will die first and it will not count as a kill. Having extra lives that re-spawn your character outside the room will not help either; you must fight the boss again.
However, if playing as Lazarus or if Lazarus' Rags is obtained, using Plan C against Delirium or Mother's second phase will net a very easy kill. One problem with Delirium is that it may quickly become an enemy that will go offscreen and become unkillable; this results in a waste of health and should only be used when low on health.
It is possible to get Delirium's Completion Mark with a random character, who isn't necessarily Lazarus, using these two items combined along with Schoolbag and the Clicker. Use Plan C, wait for your character to die and revive, then quickly use the Clicker before the end of Delirium's death animation.
Invulnerable enemies and closed Hosts will not be killed by Plan C.
Isaac's last will will show his last damage source as the cause of death, not Plan C. If Isaac has not taken damage or lost health from any source, Isaac's face is shown.
Even if Isaac enters a trapdoor immediately after using Plan C, he will still die after arriving at the next floor.
This is a reference to the "Morning After" pill that prevents pregnancy, commonly referred to as "Plan B". It's also a reference to a "cyanide pill" that is fatally poisonous and can be deliberately taken to commit suicide. It's likely that the item is called "Plan C" because it is too late for a "Plan B" to prevent Isaac from being born; so the "next best thing", Plan C, is for Isaac to kill himself. Additionally, the initial of the C is likely a further reference to the aforementioned cyanide pill.
Before the Cathedral is unlocked, the viable method for this item would be to use it on Mom's Heart (or It Lives), which would be another joke around "Plan B."
This item is found in more item pools than any other item in the game.
This page was last edited on 16 April 2021, at 00:40.
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