Placenta is a passive item.


  • Grants one full Red Heart container when picked up.
  • Isaac has a chance to regenerate a Half Red Heart every time the in-game timer hits a new minute (00:01:00, 00:02:00, etc).
  • Dlc r indicator.png Heals 1 additional heart of health.


  • The regeneration can happen multiple times in the same room, so there is no need to move between rooms to continue regeneration.
    • However, regeneration does not occur when standing in a Crawl Space.
  • Regeneration will only occur when Isaac has Red Heart containers or something equivalent:


  • Dlc r indicator.png Collectible Blood Oath icon.png Blood Oath: With enough patience, health can be safely restored each floor by waiting in the starting room.
  • Collectible Gnawed Leaf icon.png Gnawed Leaf: Regeneration works while turned to stone, allowing Isaac to become invincible and regenerate while in any room.


In-game Footage


  • A Placenta is an organ that forms from the mother's uterus during pregnancy that supports the unborn child during development until it is expelled during childbirth. In some cultures, it is a common practice for the mother and/or child to eat the expelled placenta.
    • This, like many other things Isaac does, is medically inadvisable.


PC Dlc nr indicator.png EPBF FS6M (First floor Boss Room)

PC Dlc nr indicator.png 419H 1DQM (First floor Boss Room, Gnawed Leaf in Treasure Room)


Collectible Undefined icon.png Bug! Dlc a†nr indicator.png Going into a Collectible Ventricle Razor icon.png Ventricle Razor portal at the same time the effect of Placenta is triggered will cause the effect to trigger in rapid succession, effectively healing Isaac to full health.

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