Binding of Isaac: Rebirth Wiki

Placenta is a passive item.

Effects[]

  • Grants one full Red Heart container when picked up.
  • Isaac has a 50% chance to regenerate a Half Red Heart every time the in-game timer hits a new minute (00:01:00, 00:02:00, etc).
  • (in Repentance) Heals 1 additional Red Heart when picked up.

Notes[]

  • This item can rarely drop from polyps.
  • The regeneration can happen multiple times in the same room, so there is no need to move between rooms to continue regeneration.
    • (except in Repentance) However, regeneration does not occur when standing in a Crawl SpaceCrawl Space.
  • Regeneration will only occur when Isaac has Red Heart containers or something equivalent:

Synergies[]

  • (in Repentance) Blood Oath: With enough patience, health can be safely restored each floor by waiting in the starting room.
  • Gnawed Leaf: Regeneration works while turned to stone, allowing Isaac to become invincible and regenerate while in any room.
  • (in Repentance) Sanguine Bond: Can be used indefinitely with placenta’s regen. Also works with normal sacrifice rooms
  • Sharp Plug: With enough patience, any active item can be reused indefinitely.

Interactions[]

In-game Footage[]

Trivia[]

  • A Placenta is an organ that forms from the mother's uterus during pregnancy that supports the fetus during development until it is expelled during childbirth. In some cultures, it is a common practice for the mother and/or child to eat the expelled placenta.
    • This, like many other things Isaac does, is medically inadvisable (without proper preparation methods).

Bugs[]

Bug Bug! (in Afterbirth †) Going into a Ventricle Razor portal at the same time the effect of Placenta is triggered will cause the effect to trigger in rapid succession, effectively healing Isaac to full health.