Binding of Isaac: Rebirth Wiki

Placenta is a passive item.

Effects[ | ]

  • Grants one full Red Heart container when picked up.
  • Isaac has a 50% chance to regenerate a Half Red HeartHalf Red Heart every time the in-game timer hits a new minute (00:01:00, 00:02:00, etc).
  • (in Repentance) Heals 1 additional Red HeartRed Heart when picked up.

Notes[ | ]

  • This item can rarely drop from polyps.
  • The regeneration can happen multiple times in the same room, so there is no need to move between rooms to continue regeneration.
    • (except in Repentance) However, regeneration does not occur when standing in a Crawl SpaceCrawl Space.
  • Regeneration will only occur when Isaac has Red Heart containers or something equivalent:

Synergies[ | ]

  • (in Repentance)Collectible Blood Oath iconBlood Oath: With enough patience, health can be safely restored each floor by waiting in the starting room.
  • Collectible Gnawed Leaf iconGnawed Leaf: Regeneration works while turned to stone, allowing Isaac to become invincible and regenerate while in any room.
  • (in Repentance)Collectible Sanguine Bond iconSanguine Bond: Can be used indefinitely with placenta’s regen. Also works with normal sacrifice rooms
  • Collectible Sharp Plug iconSharp Plug: With enough patience, any active item can be reused indefinitely.

Interactions[ | ]

In-game Footage[ | ]

Trivia[ | ]

  • A Placenta is an organ that forms from the mother's uterus during pregnancy that supports the unborn child during development until it is expelled during childbirth. In some cultures, it is a common practice for the mother and/or child to eat the expelled placenta.
    • This, like many other things Isaac does, is medically inadvisable (without proper preparation methods).

Bugs[ | ]

Bug Bug! (in Afterbirth †) Going into a Collectible Ventricle Razor iconVentricle Razor portal at the same time the effect of Placenta is triggered will cause the effect to trigger in rapid succession, effectively healing Isaac to full health.