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Item icon
Item altar
"HP up + regen"
Table dividing line 1.png
Item ID
Character Appearance
Character appearance
Table dividing line 2.png
Item Pool
Normal and hard modes only Boss Boss
Table dividing line 3.png
Collection Grid
Removed in Afterbirth(page 3, column 5, row 2)
Added in Afterbirth(page 2, column 15, row 5)

Placenta is a passive item.

Effects[edit | edit source]

  • Grants one full Red Heart container when picked up.
  • Isaac has a chance to regenerate a Half Red Heart every one minute of gameplay.

Notes[edit | edit source]

  • The regeneration can happen multiple times in the same room, so there is no need to move between rooms to continue regeneration.
  • It is possible to regenerate all missing hearts by simply standing in the same room for a while. Players may want to take a short break with the game not paused to regenerate all of their health.
  • Regeneration can be used with the IV Bag or Blood Donation Machine to slowly regain hearts spent, allowing for a slow yet infinite source of money from the IV Bag.
  • Regeneration does not occur when standing in a Crawl Space.
  • Added in Afterbirth Regeneration occurs with Keeper; it will restore a full health coin for him.
  • Added in Afterbirth † Regeneration occurs with The Forgotten, restoring a third of a bone heart.
  • Regeneration will not occur for ???, as he only has soul hearts.

Synergies[edit | edit source]

  • 15►Gnawed Leaf Gnawed Leaf: Allows Isaac to safely regenerate in any room.

Interactions[edit | edit source]

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • A Placenta is an organ that forms from the mother's uterus during pregnancy that supports the unborn child during development until it is expelled during childbirth. In some cultures, it is a common practice for the mother and/or child to eat the expelled placenta.
    • This, like many other things Isaac does, is medically inadvisable.

Seeds[edit | edit source]

PC EPBF FS6M (First floor Boss Room)

PC 419H 1DQM (First floor Boss Room, Gnawed Leaf in Treasure Room)

Bugs[edit | edit source]

Bug Bug! Going into a Ventricle Razor portal at the same time the effect of Placenta is triggered will cause the effect to trigger in rapid succession, effectively healing Isaac to full health.

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