Placebo

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Placebo
Item icon
Item altar
"Pill mimic"
Table dividing line 1.png
Item ID
5.100.348
Table dividing line 2.png
Recharge Time
Removed in Repentance4 rooms 4 rooms
Added in RepentanceVariable Variable
Item Pool
Normal and hard modes only Shop Shop
Greed and greedier modes only Shop Shop
Table dividing line 3.png
Collection Grid
Removed in Repentance(page 3, column 3, row 6)
Added in Repentance(page 3, column 4, row 6)
Added in Afterbirth

Placebo is an activated item added in Afterbirth.

Effect[edit | edit source]

  • Mimics the effect of Isaac's held pill, like 15►Blank Card Blank Card does with cards and Added in Repentance15►Clear Rune Clear Rune does with runes.
    • Does not consume Isaac's held pill.
    • Does not mimic cards or runes.

Recharge time Added in Repentance[edit | edit source]

In Repentance, Placebo's recharge time changes depending on the pill Isaac was holding when he used it. This is a list of the following recharge times the item can have:

  • 1 Room:
    • Bad Gas
    • Bad Trip
    • Bombs are Key
    • Feels like I'm walking on sunshine!
    • Friends Till The End!
    • Horf!
    • I Found Pills
    • Puberty
    • Something's Wrong...
    • Telepills
    • X-Lax
  • 2 Rooms:
    •  ???
    • Addicted!
    • Infested?
    • Infested!
    • Percs!
    • Pheromones
    • Re-Lax
  • 3 Rooms:
    • Amnesia
    • Explosive Diarrhea
    • I'm Drowsy...
    • I'm Excited!!!
    • Lemon Party
    • Paralysis
    • Power Pill!
    • R U A Wizard?
    • Retro Vison
  • 4 Rooms:
    • Gulp!
    • I can see forever!
    • Stat-downs (health, range, speed, tears, luck, shot speed)
  • 6 Rooms:
    • Hematemesis
    • Experimental Pill
    • Vurp!
  • 12 Rooms:
    • 48 Hour Energy
    • Balls of Steel
    • Full Health
    • One makes you larger/small
    • Pretty Fly
    • Stat-ups (health, range, speed, tears, luck, shot speed)

Golden Pills use the recharge time of the pill they mimicked. Recharge time is unaffected by whether or not it was a normal pill or Horse Pill.

Note that because the recharge time is determined after using the pill, Placebo cannot be used as a way to narrow down what type of pill Isaac is holding before he uses it.

Synergies[edit | edit source]

Interactions[edit | edit source]

  • 15►Starter Deck Starter Deck: All pills are replaced by cards, rendering Placebo useless.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.


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