Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Placebo is an activated item added in Afterbirth.


  • Mimics the effect of Isaac's held pill, like 15►Blank Card Blank Card does with cards and Added in Repentance15►Clear Rune Clear Rune does with runes.
    • Does not consume Isaac's held pill.
    • Does not mimic cards or runes.

Recharge time Added in Repentance[]

In Repentance, Placebo's recharge time changes depending on the pill Isaac was holding when he used it. This is a list of the following recharge times the item can have:

  • 1 Room:
    • Bad Gas
    • Bad Trip
    • Bombs are Key
    • Feels like I'm walking on sunshine!
    • Friends Till The End!
    • Horf!
    • I Found Pills
    • Puberty
    • Something's Wrong...
    • Telepills
    • X-Lax
  • 2 Rooms:
    •  ???
    • Addicted!
    • Infested?
    • Infested!
    • Percs!
    • Pheromones
    • Re-Lax
  • 3 Rooms:
    • Amnesia
    • Explosive Diarrhea
    • I'm Drowsy...
    • I'm Excited!!!
    • Lemon Party
    • Paralysis
    • Power Pill!
    • R U A Wizard?
    • Retro Vision
  • 4 Rooms:
    • Gulp!
    • I can see forever!
    • Stat-downs (health, range, speed, tears, luck, shot speed)
  • 6 Rooms:
    • Hematemesis
    • Experimental Pill
    • Vurp!
  • 12 Rooms:
    • 48 Hour Energy
    • Balls of Steel
    • Full Health
    • One makes you larger/small
    • Pretty Fly
    • Stat-ups (health, range, speed, tears, luck, shot speed)

Golden Pills use the recharge time of the pill they mimicked. Recharge time is unaffected by whether or not it was a normal pill or Horse Pill.

Note that because the recharge time is determined after using the pill, Placebo cannot be used as a way to narrow down what type of pill Isaac is holding before he uses it.


  • Removed in Repentance Balls of Steel + 15►Sharp Plug Sharp Plug: The player can gain functional invincibility.
    • Removed in Repentance 15►The Wafer The Wafer: Allows for Virtually infinite health.
  • Removed in Repentance48 Hour Energy: Can spawn an unlimited number of Lil' Batteries, allowing unlimited use of another activated item or pill.
  • Added in Repentance Vurp: Allows pills that normally take 12 rooms for Placebo to charge to be used twice as frequently.
  • Added in RepentanceButter! Butter! Because Placebo is dropped upon usage, the recharge time is reset to 4, allowing to use more expensive pills much more frequently.


  • 15►Starter Deck Starter Deck: All pills are replaced by cards, rendering Placebo useless.
  • If used with Bethany Bethany or Tainted Bethany Tainted Bethany, using a pill that has a larger charge requirement than Placebo's current will still consume soul or blood charges equal to the difference (likely a bug).

In-game Footage[]


  • Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.


Bug Bug! Strange behavior when the player has a 12-charge pill, Placebo is dropped on the ground with more than 4 charges and the player has Battery - when the player re-equips Placebo, it's capped at 8 charges, which stack strangely in the UI

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