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Item icon
Item altar
"Pill mimic"
Table dividing line 1.png
Item ID
Table dividing line 2.png
Recharge Time
Removed in Repentance4 rooms 4 rooms
Added in RepentanceVariable Variable
Item Pool
Normal and hard modes only Shop Shop
Greed and greedier modes only Shop Shop
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Collection Grid
Removed in Repentance(page 3, column 3, row 6)
Added in Repentance(page 3, column 4, row 6)
Added in Afterbirth

Placebo is an activated item added in Afterbirth.

Effect[edit | edit source]

  • Mimics the effect of Isaac's held pill, like 15►Blank Card Blank Card does with cards and Added in Repentance15►Clear Rune Clear Rune does with runes.
    • Does not consume Isaac's held pill.
    • Does not mimic cards or runes.

Recharge time Added in Repentance[edit | edit source]

In Repentance, Placebo's recharge time changes depending on the pill Isaac was holding when he used it. This is a list of the following recharge times the item can have:

  • 1 Room:
    • Bad Gas
    • Bad Trip
    • Bombs are Key
    • Feels like I'm walking on sunshine!
    • Friends Till The End!
    • Horf!
    • I Found Pills
    • Puberty
    • Something's Wrong...
    • Telepills
    • X-Lax
  • 2 Rooms:
    •  ???
    • Addicted!
    • Infested?
    • Infested!
    • Percs!
    • Pheromones
    • Re-Lax
  • 3 Rooms:
    • Amnesia
    • Explosive Diarrhea
    • I'm Drowsy...
    • I'm Excited!!!
    • Lemon Party
    • Paralysis
    • Power Pill!
    • R U A Wizard?
    • Retro Vison
  • 4 Rooms:
    • Gulp!
    • I can see forever!
    • Stat-downs (health, range, speed, tears, luck, shot speed)
  • 6 Rooms:
    • Hematemesis
    • Experimental Pill
    • Vurp!
  • 12 Rooms:
    • 48 Hour Energy
    • Balls of Steel
    • Full Health
    • One makes you larger/small
    • Pretty Fly
    • Stat-ups (health, range, speed, tears, luck, shot speed)

Golden Pills use the recharge time of the pill they mimicked. Recharge time is unaffected by whether or not it was a normal pill or Horse Pill.

Note that because the recharge time is determined after using the pill, Placebo cannot be used as a way to narrow down what type of pill Isaac is holding before he uses it.

Synergies[edit | edit source]

Interactions[edit | edit source]

  • 15►Starter Deck Starter Deck: All pills are replaced by cards, rendering Placebo useless.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.

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