Binding of Isaac: Rebirth Wiki

(except in Rebirth)

Placebo is an activated item added in The Binding of Isaac: Afterbirth.

Effects[ | ]

  • (except in Repentance) Mimics the effect of Isaac's held pill.
  • (in Repentance) Mimics the effect of Isaac's held pill. Placebo's recharge time changes upon use, depending on the pill Isaac was holding when he used it.

Notes[ | ]

  • (in Repentance) The item only costs 10 coins when found in a ShopShop.
  • Unknown pills are identified when mimicked.

Recharge time (in Repentance)[ | ]

This is a list of the following recharge times the item can have, depending on the consumable it mimicked last:

  • 1 Room:
    • Bad Gas
    • Bombs are Key
    • Feels like I'm walking on sunshine!
    • Friends Till The End!
    • Horf!
    • I Found Pills
    • Puberty
    • Something's Wrong...
    • Telepills
    • X-Lax
  • 2 Rooms:
    • Bad Trip
    • Infested?
    • Infested!
    • Percs!
    • Pheromones
    • Re-Lax
  • 3 Rooms:
    • Experimental Pill
    • Explosive Diarrhea
    • I'm Drowsy...
    • Lemon Party
    • Power Pill!
  • 4 Rooms:
    • Gulp!
    • I can see forever!
    • Stat-downs (health, range, speed, tears, luck, shot speed)
  • 6 Rooms:
    • ???
    • Addicted!
    • Amnesia
    • Hematemesis
    • I'm Excited!!!
    • One makes you larger
    • One makes you small
    • Paralysis
    • Pretty Fly
    • R U A Wizard?
    • Retro Vision
    • Vurp!
    • Stat-ups (health, range, speed, tears, luck, shot speed)
  • 12 Rooms:
    • 48 Hour Energy
    • Balls of Steel
    • Full Health

Golden Pills use the recharge time of the pill they mimicked. Recharge time is unaffected by whether or not it was a normal pill or Horse Pill.

Note that because the recharge time is determined after using the pill, Placebo cannot be used as a way to narrow down what type of pill Isaac is holding before he uses it.

Synergies[ | ]

  • 48 Hour Energy:
  • (except in Repentance) Balls of Steel + Collectible Sharp Plug iconSharp Plug: The player can gain functional invincibility.
    • (except in Repentance) Collectible The Wafer iconThe Wafer: Allows for Virtually infinite health.
  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Spawns white wisps on the middle ring. The wisps spawn Pills when destroyed. The effects of the wisps and types of pills they spawn is independent from Placebo's charge time and the most recently used pill. Unlike Collectible Blank Card iconBlank Card and Collectible Clear Rune iconClear Rune, enemies killed by these wisps' tears do not have a chance to drop pills.
  • (in Repentance)Butter!Butter!: Because Placebo is dropped upon usage, the recharge time is reset to 4, allowing to use more expensive pills much more frequently.
  • (in Repentance) Vurp: Allows pills that normally take 12 rooms for Placebo to charge to be used twice as frequently.

Interactions[ | ]

  • Collectible Starter Deck iconStarter Deck: All pills are replaced by cards, rendering Placebo useless.
  • If used with Character Bethany iconBethany or Character Tainted Bethany iconTainted Bethany, using a pill that has a larger charge requirement than Placebo's current will still consume soul or blood charges equal to the difference (likely a bug).

In-game Footage[ | ]

Trivia[ | ]

  • Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.
  • This item is a pill counterpart to Collectible Blank Card iconBlank Card and (in Repentance)Collectible Clear Rune iconClear Rune.