Pitch Black is challenge #1. During this challenge, Curse of Darkness and Curse of the Unknown will be permanently active. Unlike other challenges, treasure rooms are available, but shops are not. The goal is to defeat Mom. This challenge is unlocked by default.
The curses inflicted are typically trivial on their own, however, they are the primary source of difficulty in this challenge due to the permanence of Curse of the Unknown, making it much more difficult to keep track of Isaac's health. This also makes it especially risky when using mechanics that drain Isaac's health, such as devil deals or blood donation machines. Additionally, Curse of Darkness, although mostly just thematic, does contribute to the difficulty of the challenge by making it harder to spot tinted rocks, which normally would aid Isaac's survival with soul hearts. As well as this, Black Candle doesn't clear any of the curses in this challenge.
While Devil deals can provide powerful items, taking one is very risky unless Isaac's health is carefully tracked. Refraining from deals can give access to angel rooms, which can provide items without the need to sacrifice health.
Turning the gamma setting up in the options can lessen the impact of Curse of Darkness.
While entering one is not recommended, finding a door to a Boss Challenge Room can at least gauge Isaac's health by checking whether it's open or closed.
|1. Pitch Black||2. High Brow||3. Head Trauma||4. Darkness Falls||5. The Tank|
|6. Solar System||7. Suicide King||8. Cat Got Your Tongue||9. Demo Man||10. Cursed!|
|11. Glass Cannon||12. When Life Gives You Lemons||13. Beans!||14. It's in the Cards||15. Slow Roll|
|16. Computer Savvy||17. Waka Waka||18. The Host||19. The Family Man||20. Purist|
|21. XXXXXXXXL||22. SPEED!||23. Blue Bomber||24. PAY TO PLAY||25. Have a Heart|
|26. I RULE!||27. BRAINS!||28. PRIDE DAY!||29. Onan's Streak||30. The Guardian|
|31. Backasswards||32. Aprils Fool||33. Pokey Mans||34. Ultra Hard||35. Pong|
|36. Scat Man||37. Bloody Mary||38. Baptism by Fire||39. Isaac's Awakening||40. Seeing Double|
|41. Pica Run||42. Hot Potato||43. Cantripped!||44. Red Redemption||45. DELETE THIS|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|