Pills

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Pills are pickups that can provide useful or inhibiting effects. They take up the same slot as cards and runes.

At the start of each run, an effect is randomly assigned to each color of the pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for 15►PHD PHD, 15►Virgo Virgo, Added in Repentance15►False PHD False PHD, or Added in Repentance15►Lucky Foot Lucky Foot to reassign some of the effects, such that 2 different colored pills will have the same effect). Pills will start the game unidentified (unless the player is holding 15►PHD PHD or Added in Repentance15►False PHD False PHD), their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the pill pool.

  • Added in Afterbirth The pill pool for each run has increased from 9 to 13.

Added in Repentance Repentance introduces Horse Pills. They appear as larger versions of the standard pills with a more powerful effect, and their effects and appearances are similarly randomly chosen. All items that work with pills work identically with horse pills. A horse pill with a given effect has the same color as the normal pill does. Unlocked by: Horse Pill Defeat Mega Satan as Tainted Eve Tainted Eve.


Pill Effects[edit | edit source]

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Issues: The remaining horse pill effects require more research.

ID Pill Effect Added in Repentance Horse Pill Effect
0 Bad Gas Isaac farts, dealing 5 damage and poisoning enemies around him. The poison applies to the entire room.
1 Bad Trip Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead.
Added in Repentance This doesn't count as damage for the purposes of Devil/Angel Room generation odds or score reduction.
Two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
2 Balls of Steel Grants Isaac two soul hearts. Grants four soul hearts.
3 Bombs Are Key Swaps the values of Isaac's bombs and keys.
Added in RepentanceThe effects of Golden Bombs and Golden Keys are also swapped.
The number of bombs and keys is increased by 50% while swapping.
4 Explosive Diarrhea Spawns five active bombs behind Isaac over a period of five seconds, at one a second. Spawns more bombs, boosted with 15►Mr. Mega Mr. Mega and 15►Bobby-Bomb Bobby-Bomb.
5 Full Health Refills every empty red heart container. Fully heals and grants 3 soul hearts.
6 Health Down Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a Health Up pill instead. ??? can encounter Health Down pills, even though he can't have red heart containers. Removes two heart containers. If this is not possible, the pill becomes Health Up.
7 Health Up Adds one empty red heart container upon use. Adds two empty red heart containers.
8 I Found Pills Changes the appearance of Isaac's face. This pill is cosmetic only, Removed in Afterbirth, and the effect disappears when you leave the room. Isaac's face gets a permanent, very exaggerated expression.
9 Puberty Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.
Added in Afterbirth † Consuming three puberty pills will grant the Adult transformation, granting one red heart container (one time effect).
Isaac gains very fluffy hair covering his entire head and even face.
10 Pretty Fly Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging fly-type enemies on touch. Spawns a 15►Big Fan Big Fan instead. There is no upper limit.
11 Range Down Removed in Repentance-2.00 range.
Added in Repentance-0.60 range.
-1.20 range.
12 Range Up Removed in Repentance+2.50 range.
Added in Repentance+0.75 range.
+1.50 range.
13 Speed Down -0.12 speed. -0.24 speed.
14 Speed Up +0.15 speed. +0.30 speed.
15 Tears Down -0.28 tears. -0.56 tears.
16 Tears Up +0.35 tears. +0.70 tears.
17 Luck Down -1 luck. -2 luck.
18 Luck Up +1 luck. +2 luck.
19 Telepills Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the I AM ERROR room, and an extremely small chance to teleport him to the Black Market, like 15►Undefined Undefined. Unobtainable in Greed Mode. Unknown.
20 48 Hour Energy Drops one to two little batteries and fully charges the spacebar item. Added in Afterbirth Can be used with the Added in Afterbirth15►Placebo Placebo or Added in Afterbirth †15►D1 D1 to generate infinite batteries. Spawns more batteries.
21 Hematemesis Empties all but one red heart container and spawns 1-4 red hearts. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a black heart or eternal heart-containing super secret room, it will spawn those types of hearts instead. Spawns more hearts.
22 Paralysis Prevents Isaac from moving and shooting for 2 seconds. The effect lasts 4 seconds.
23 I can see forever! Opens all entrances to the secret room and super secret room for the current floor. In addition to the normal effect, fully reveals the map like 15►The Mind The Mind.
24 Pheromones Charms all enemies in the room for a short period of time. The charm is permanent, turning the enemies friendly.
25 Amnesia Replaces the floor map with a ? for the rest of the floor, identical to the effect of Curse of the Lost. If no other curses are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect can be negated by picking up 15►Black Candle Black Candle, but will not prevent future uses of the Amnesia pill from giving the Curse of the Lost effect. Added in Afterbirth Also the only pill to have its flavor text appear on a piece of paper as curses do. Unknown.
26 Lemon Party Spawns a large yellow pool (similar to 15►Lemon Mishap Lemon Mishap) around your character. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second. The puddle covers nearly the entire room.
27 R U a Wizard? Tears are shot diagonally outwards for about 30 seconds. This effect does not reset upon exiting the room. The effect lasts 60 seconds.
Added in Afterbirth Afterbirth
28 Needs to be unlocked Percs! Gives 15►The Wafer The Wafer effect while in the room: reduces all damage taken to half a heart.
Unlocked by: Added in Afterbirth2 new pills Complete PAY TO PLAY (challenge #24).
Unknown.
29 Needs to be unlocked Addicted! Makes Isaac take a full heart of damage from all sources for the current room. Also changes his appearance for the room.
Unlocked by: Added in Afterbirth2 new pills Complete PAY TO PLAY (challenge #24).
Unknown.
30 Needs to be unlocked Re-Lax For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives.
Unlocked by: Added in Afterbirth2 new pills 2 Complete Have a Heart (challenge #25).
The effect lasts much longer, with high speed long enough to cover nearly the entire room.
31 Needs to be unlocked ??? Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect can be negated by picking up 15►Black Candle Black Candle, but will not prevent future uses of the ??? pill from giving the Curse of the Maze effect. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.
Unlocked by: Added in Afterbirth2 new pills 2 Complete Have a Heart (challenge #25).
Unknown.
32 One makes you larger Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox but will increase the size of The Forgotten's bone club. Added in Afterbirth † These pills contribute to the Stompy transformation. Size increases by two steps.
33 One makes you small Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox. Size decreases by two steps.
34 Infested! Destroys all poop in the room and spawns a single blue spider under Isaac and on each destroyed poop. Double the number of spiders spawned.
35 Infested? Spawns blue spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders. Double the number of spiders spawned.
36 Power Pill! Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to 15►The Gamekid The Gamekid. In addition to the normal effect, grants Added in Afterbirth †Huge Growth Huge Growth for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
37 Retro Vision Removed in RepentancePixelates the screen 3 times over 30 seconds. The effect continues between floors.

Added in RepentanceGives the game a (different) pixelated filter for 30 seconds once. The effect continues between floors.

Lasts 90 seconds, with no breaks.
38 Friends Till The End! Spawns three blue flies. Double the number of flies spawned.
Added in Afterbirth † Afterbirth †
39 X-Lax Creates a pool of slippery brown creep underneath Isaac. The pool lasts much longer.
40 Something's wrong... Creates a pool of black creep beneath Isaac that slows enemies. The pool lasts much longer.
41 I'm Drowsy... Removed in Repentance Slows all enemies for the duration of the room.
Added in Repentance Slows all enemies, Isaac, and the background music for the duration of the room.
Unknown.
42 I'm Excited!!! Removed in Repentance Increases the speed of all enemies for the duration of the room.
Added in Repentance Increases the speed of all enemies, Isaac, and the background music for the duration of the room.
The effect triggers again 30 seconds after use and 60 seconds after use.
Unknown.
43 Needs to be unlocked Gulp! Any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player.
Unlocked by: Added in Afterbirth †Once More with Feeling! Complete a Victory Lap, defeating The Lamb.
Unknown.
44 Needs to be unlocked Horf! Isaac shoots an explosive tear with the 15►Ipecac Ipecac effect that always deals 200 damage.
Unlocked by: Added in Afterbirth †Dedication Participate in 31 daily challenges (they don't have to be consecutive; it will still count if you die in the first room).
Isaac shoots a small cluster of Horf! tears, with varying power above normal Horf!.
45 Needs to be unlocked Feels like I'm walking on sunshine! Temporarily makes Isaac invincible, similar to 15►Unicorn Stump Unicorn Stump.
Unlocked by: Added in Afterbirth †Sin collector Collect every entry in the Bestiary (bugged v190 - Mobs that don't exist in the bestiary are being counted. This allows Sin Collector to be unlocked without a complete bestiary).
The effect is upgraded to 15►The Gamekid The Gamekid.
46 Needs to be unlocked Vurp! Throws up the last pill used. Will spawn itself if no other pills were taken beforehand, or if Vurp! was the last pill used.
Unlocked by: Added in Afterbirth †U Broke It! Obtain 50 items on a run (e.g., via two 15►Steam Sale Steam Sale and Added in Afterbirth15►Restock Restock - Duplicate passives/familiars count towards the total, e.g., multiple 15►Breakfast Breakfast).
If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
Added in Repentance Repentance
47 Shot Speed Down -0.15 shot speed. -0.30 shot speed.
48 Shot Speed Up +0.15 shot speed. +0.30 shot speed.
49 Experimental Pill Increases one attribute and decreases another randomly, with the same power as normal attribute up/down pills. If taken with PHD, it will not reduce an attribute. The two effects are doubled in power.
none Gold Pill Always shown as "???", this pill will give a random pill effect and will be destroyed upon a random number of uses.
Unlocked by: Added in RepentanceGold Pill Defeat Mega Satan as Tainted Cain Tainted Cain.
The random effects are doubled.

Pill appearances[edit | edit source]

ID Pill
1 BlueBlue.png
2 WhiteBlue.png
3 OrangeOrange.png
4 Pill WhiteWhite.png
5 RedSpecled.png
6 WhiteRed.png
7 BlueCyan.png
8 YellowOrange.png
9 SpottedwhiteWhite.png
Added in Afterbirth Afterbirth
10 Pill White Cyan.png
11 Pill Black Yellow.png
12 Pill Black White.png
13 Pill White Yellow.png

Notes[edit | edit source]

  • Among the attribute modifying pill effects, only five of the seven visible attributes are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
    • Added in Repentance Shot speed can now be altered with pills. Damage can now also be altered with pills with False PHD.
  • Added in Afterbirth Pill effects have a chance to be narrated upon use, as do cards and runes.
  • Added in Afterbirth Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
  • Added in Afterbirth The "Addicted!" pill will have no effect if Isaac has 15►The Wafer The Wafer.
    • Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
  • Having 15►Midas' Touch Midas' Touch, Added in Afterbirth †Meconium Meconium, or Added in Afterbirth †15►Hallowed Ground Hallowed Ground and using a "Re-Lax" pill has a chance to spawn golden poop, black poop, or white poop, respectively.
  • Added in Afterbirth Using an "Infested!" pill on red poop will spawn blue spiders and the red poop will regenerate.
  • Added in Afterbirth If a Tiny or Large Champion monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
  • Added in Afterbirth "R U A Wizard" does not affect Lilith's Incubus.
  • Added in Afterbirth † Using a "Gulp!" pill while holding two trinkets (with Added in Afterbirth †15►Belly Button Belly Button or 15►Mom's Purse Mom's Purse) will cause both trinkets to be absorbed.
  • Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.

Strategy[edit | edit source]

  • Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, Added in AfterbirthAddicted!, Added in Afterbirth † X-Lax, and Added in Afterbirth † I'm Excited!!! can be detrimental mid-fight. However, Added in Afterbirth † I'm Drowsy..., Added in Afterbirth † Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
  • Added in Afterbirth Percs! can be used in the sacrifice room to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
  • Added in Afterbirth The invincibility effect from Power Pill and Added in Afterbirth † Feels like I'm walking on sunshine! can be utilized to get into curse rooms, play blood donation machines, or use Devil beggars without taking any damage.
    • Added in Afterbirth Percs! can be used to reduce damage from these from chapter 4 onward.

Unlockable achievements[edit | edit source]

  • Lachryphagy
    Added in Afterbirth † Lachryphagy - Collect 10 "tears up" items or pills in one run.

Trivia[edit | edit source]

  • Lemon Party is an internet shock site featuring a group of elderly men performing oral sex.
  • Added in Afterbirth † The Vurp! pill is a portmanteau of the words vomit and burp.
  • Added in Afterbirth Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
  • "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all image macro memes.
    • Despite being called I Can See Forever, the effects only last for the rest of that floor.
  • Added in Afterbirth † The Feels like I'm walking on sunshine! pill is a reference to the 80s song Walking on Sunshine.
  • Balls of Steel is a reference to Duke Nukem; it is one of Duke's more famous quotes.
  • Explosive Diarrhea is extremely loud and forceful diarrhea. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
  • Added in Afterbirth Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
  • Added in Afterbirth / Removed in Afterbirth † Friends Till The End! is the only non-narrated pill.
  • 48 Hour Energy is a reference to the drink 5 Hour Energy.
  • Added in Afterbirth † X-Lax is a reference to the anti-constipation medicine Ex-Lax.
  • Added in Afterbirth "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
  • Added in Afterbirth "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
  • Added in Afterbirth The "???" is the only pill that has 3 different narrated voice lines.

Voiceovers[edit | edit source]

Pill Voiceover
???

48 Hour Energy
Addicted
Amnesia
Bad Gas
Bad Trip
Balls of Steel
Bombs Are Key
Feels like I'm walking on sunshine!
Friends Till the End!
Full Health
Gulp!
Health Down
Health Up
Hematemesis
Horf!
I Can See Forever
I Found Pills
I'm Drowsy...
I'm Excited!!!
Infested!
Infested?
Lemon Party
Luck Down
Luck Up
One Makes You Larger
One Makes You Small
Paralysis
Percs
Pheromones
Power Pill
Pretty Fly
Puberty
R U a Wizard?
Range Down
Range Up
Re-Lax
Retro Vision
Something's wrong...
Speed Down
Speed Up
Tears Down
Tears Up
Telepills
Vurp!
X-Lax

Gallery[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets