Pickups

Pickups are minor items that can be found around the game.

Pickups can be found from any of the following sources:

Semi-randomly being placed in rooms.
Found inside of chests.
Dropped by any kind of beggar.

Dropped after clearing a room.
Found after blasting tinted rocks.
Dropped by various slot machines.

Dropped after defeating a champion monster.
Bought in shops.
Generated as part of an item effect.

Hearts

Hearts are the standard HP for most characters and can be found in various varieties. The player cannot have more red hearts than heart containers, but certain heart pickups can circumvent that limit.

Coins

Coins serve as the currency for shops, the payment for the Donation Machine in shops, and payment for the slot machines, fortune telling machines, shell game, beggars, and Restock Boxes. They are also consumed to use a few activated items (most notably Magic Fingers and Portable Slot). They will naturally drop as a Penny, a Nickel, and rarely a Dime.

Bombs

Bombs are used to damage enemies, destroy rocks, and open up regular doors and secret rooms. When spawned, there is a possibility for it to be a Troll Bomb instead.

Keys

Keys are used to gain entry to many of the game's rooms, as well as unlocking golden chests and key blocks.

Batteries

Batteries will fully charge your activated item upon pickup.

Pills

See Pills.

Cards

See Cards and Runes.

Chests

See Chests.

Sacks

Sacks will spawn 1-4 pickups upon touching them.

Notes

When the "KEEP AWAY" seed is enabled, all pickups will mimic Isaac's movements.
When the "GONE SOON" seed is enabled, all pickups will quickly fade.
When the "CAMO DROP" seed is enabled, all pickups (and items) will blend into the ground.

The Binding of Isaac: Rebirth