Pica Run

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Pica   Run
Character Isaac appearance.png
red: 3
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: yes          Item Pool Shop.png: yes
Boss Isaac.png
Ice Cube Ice Cube
Unlock Method

Pica Run Defeat Mom's Heart 11 times and Unlock Marbles

Added in Repentance

Pica Run is challenge #41. The goal is to defeat Isaac. This challenge is unlocked by defeating Mom's Heart 11 times.

Strategy[edit | edit source]

The challenge is played as Isaac, who starts with 15►Mom's Box Mom's Box, 15►Marbles Marbles and 15►Mom's Purse Mom's Purse, resulting in 4 random trinkets spawned on the floor in the starting room. All item pedestals are replaced with trinket drops. Only purchasable items such as those from Shops and Devil Rooms remain unaffected.

Unlike its usual function, Marbles now causes Isaac to swallow his held trinkets every time he takes damage, rather than having a low chance of occurring. This allows building up a large collection of trinkets, quite easily making up for the lack of regular items. However, this has its downsides - some trinkets on their own or in combination with others can have undesirable or even disastrous results, such as wild teleportation or spontaneous explosions. If there is any uncertainty, looking up the trinket before committing to it by having it swallowed is recommended.

If you have a way to heal your red hearts, Devil Beggars can be extremely usefull to swallow more trinkets while keeping your soul hearts and Devil room chance.

Certain Trinkets are much more valuable than others at the beginning of a run, especially since Mom's Box, Isaac's starting active item in this run, doubles the effects of most Trinkets. Since four Trinkets are given to you to start with, it may be useful to restart until you find one (or more) of the following:

Unlockable achievements[edit | edit source]

  • Ice Cube
    Ice Cube - Complete Pica Run (challenge #41).

Notes[edit | edit source]

  • In this challenge, every trinket is unlocked. This allows the player to see new trinkets they still have to unlock.

Trivia[edit | edit source]

  • Pica is a psychological disorder where a person experiences a compulsion to eat inedible objects and substances.

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1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
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21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
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Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
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