Binding of Isaac: Rebirth Wiki
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(in Repentance)

Panic Button is a trinket added in The Binding of Isaac: Repentance.

Effects[ | ]

  • Activates Isaac's active item just before damage would be taken.
    • This still uses the item's charges so if the item is not charged, the trinket will do nothing.
    • Single-use items will be consumed.

Notes[ | ]

  • Panic Button will attempt to use the item 2-3 times per tick as damage is incoming. This may cause some unlimited use items to trigger multiple times before one damage instance.
  • Some items will be activated after respawning if Isaac is killed by the incoming damage, including Collectible Guppy's Paw iconGuppy's Paw and Collectible Mega Blast iconMega Blast.
  • Taking damage from explosions, enemy creep, spikes and spike rocks, Spiked ChestSpiked Chest and Mimic chest RepentanceMimic Chest, some attack from above (for example, the stomp attacks from Boss Mom ingameMom and Boss Satan ingameSatan), WhipperWhipper and their variants, brimstone lasers (including angel lasers), electric lasers, self-damage items, Devil BeggarDevil Beggar, Hell GameHell Game, Blood Donation MachineBlood Donation Machine, and ConfessionalConfessional will not trigger the effect.
  • Does not activate items in a consumable slot (such as Character Tainted Bethany iconTainted Bethany's Collectible Lemegeton iconLemegeton or dice items granted by Dice BagDice Bag).
  • Will activate when touching Dark EsauDark Esau while playing as Character Tainted Jacob iconTainted Jacob, despite Dark Esau not technically dealing damage.
    • This effect still occurs even whilst he is chained by Collectible Anima Sola iconAnima Sola, when he deals no contact damage.

Interactions[ | ]

  • Any self-damaging item: Self-damage occurs before enemy damage, making it almost impossible to lose Devil/Angel Room chances.
    • For self-damaging items that deals only half a heart damage (such as Collectible Kamikaze! iconKamikaze!), before chapter 4, it will also reduce enemy damage to half a heart, similarly to Collectible The Wafer iconThe Wafer.
  • Collectible Blank Card iconBlank Card with VII - The ChariotVII - The Chariot / VII - The Chariot?VII - The Chariot?: Activate their respective effects without consuming it.
  • Collectible Blood Rights iconBlood Rights: Triggers the effect on hit, at the cost of a full-heart of damage on the first hit and half-heart damage on subsequent hits in the same room.
  • Collectible Book of Shadows iconBook of Shadows: Activates the item, giving Isaac the shield effect for 10 seconds.
  • Collectible Bursting Sack iconBursting Sack: Even though the neutral spiders spawned by the item can't possibly hurt Isaac, the trinket still activates when contact is made with them.
  • Collectible Butter Bean iconButter Bean / Collectible Wait What iconWait What?: Isaac farts before being hit, knocking back enemies and projectiles.
  • Collectible Clear Rune iconClear Rune with Rune of AlgizRune of Algiz / Blank RuneBlank Rune / Rune ShardRune Shard / Soul of JudasSoul of Judas: Activate their respective effects without consuming it.
  • Collectible Dark Arts iconDark Arts: Unlike many other items on this list, Dark Arts can be used to negate damage more than once per room, making it an excellent defensive item to use with Panic Button. Note that this does not work while playing as Character Tainted Judas iconTainted Judas.
  • Collectible Damocles iconDamocles: Not recommended. Damocles will activate right before Isaac takes damage, guaranteeing Damocles will fall later in the run even if Isaac hasn't activated it yet.
  • Collectible Dull Razor iconDull Razor: Activates the item and gives Isaac invincibility frames before being hit, making it work similarly to Collectible Holy Mantle iconHoly Mantle every two rooms. If combined with Collectible 9 Volt icon9 Volt or AAA BatteryAAA Battery, works every room, just like Holy Mantle. If combined with Collectible The Battery iconThe Battery Collectible Habit iconHabit and Collectible Car Battery iconCar Battery it will make Isaac almost invincible.
  • Collectible Glowing Hourglass iconGlowing Hourglass: If consumed with Collectible Void iconVoid, every time Isaac is hit, if it's charged, he is sent back to the previous room without taking damage.
  • Collectible Holy Mantle iconHoly Mantle: Does not stop the trinket from activating, making Isaac still take damage from items such as Collectible IV Bag iconIV Bag, while bypassing Holy Mantle's shield.
    • Character The Lost iconThe Lost can die this way should he carry self damaging items at the time of the hit.
  • Collectible How to Jump iconHow to Jump: Makes Isaac immune to contact and tear damage while moving.
  • Collectible IV Bag iconIV Bag: Upon getting hit, activates the IV Bag instead, causing self-damage and producing money.
  • Collectible Kamikaze! iconKamikaze!: Causes a highly-damaging explosion to occur every time Isaac is hit, similarly to Swallowed M80Swallowed M80.
  • Collectible My Little Unicorn iconMy Little Unicorn: Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
  • Collectible Razor Blade iconRazor Blade: Isaac gains a damage boost every time he's hit, acting similarly to Red PatchRed Patch, at the cost of a full-heart of damage on the first hit and half-heart damage on subsequent hits in the same room.
  • Collectible Spin to Win iconSpin to Win: Has a chance to spawn additional wheels upon taking damage that last only for the current room. This is most likely a bug.
  • Collectible Stitches iconStitches: Isaac will teleport before damage is taken, making him much harder to hit.
  • Character Tainted Forgotten iconTainted Forgotten: Triggers his active item whenever the body touches something that would damage The Soul, regardless of damage taken.
  • Collectible Suplex! iconSuplex!: As long as Suplex! is fully charged, Panic Button automatically triggers when about to take damage, avoiding the damage and potentially grabbing an enemy in the process. Allows Isaac to grab an enemy by simply walking into them, provided the item is charged.
  • Collectible Telekinesis iconTelekinesis: Automatically blocks any incoming shots, but the push is not strong enough to prevent contact damage.
  • Collectible The Gamekid iconThe Gamekid: Turns the character into a Pac-Man-like creature for 6.5 seconds and provides invulnerability, inflicts fear on all enemies, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
  • Collectible Unicorn Stump iconUnicorn Stump: Gives invulnerability and +0.28 speed for six seconds, but removes the ability to shoot tears while the effect is active.
  • Collectible Yum Heart iconYum Heart: Since the effect is triggered before taking damage, Panic Button will waste the charge with no benefit unless Isaac is already missing Red health.

In-game footage[ | ]


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