Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Panic Button is a trinket added in The Binding of Isaac: Repentance.


  • Activates Isaac's active item just before damage would be taken.
    • This still uses the item's charges so if the item is not charged, the trinket will do nothing.
    • Single-use items will be consumed.



  • Any self-damaging item: Self-damage occurs before enemy damage, making it almost impossible to lose Devil/Angel Room chances.
    • For self-damaging items that deals only half a heart damage (such as Kamikaze! Kamikaze!), before chapter 4, it will also reduce enemy damage to half a heart, similarly to The Wafer The Wafer.
  • Blood Rights Blood Rights: Triggers the effect on hit, at the cost of every hit making Isaac take full-heart damage.
  • Butter Bean Butter Bean / Wait What? Wait What?: Isaac farts before being hit, knocking back enemies and projectiles.
  • Dull Razor Dull Razor: Activates the item and gives Isaac invincibility frames before being hit, making it work similarly to Holy Mantle Holy Mantle every two rooms. If combined with 9 Volt 9 Volt or AAA Battery AAA Battery, works every room, just like Holy Mantle.
  • Glowing Hour Glass Glowing Hour Glass: If consumed with Void Void, every time Isaac is hit, if it's charged, he is sent back to the previous room without taking damage.
  • Holy Mantle Holy Mantle: Does not stop the trinket from activating, making Isaac still take damage from items such as IV Bag IV Bag, while bypassing Holy Mantle's shield.
    • The Lost The Lost can die this way should he carry self damaging items at the time of the hit.
  • How to Jump How to Jump: Makes Isaac immune to contact and tear damage while moving.
  • IV Bag IV Bag: Upon getting hit, activates the IV Bag instead, causing red heart damage and producing money.
  • Kamikaze! Kamikaze!: Causes a highly-damaging explosion to occur every time Isaac is hit, similarly to Swallowed M80 Swallowed M80.
  • Razor Blade Razor Blade: Isaac gains a damage boost every time he's hit, acting similarly to Red Patch Red Patch, at the cost of every hit making Isaac take full-heart damage.
  • Spin to Win Spin to Win: Has a chance to spawn additional wheels upon taking damage that last only for the current room. This is most likely a bug.
  • Stitches Stitches: Isaac will teleport before damage is taken, making him much harder to hit.
  • Tainted Forgotten Tainted Forgotten: Triggers his active item whenever the body touches something that would damage The Soul, regardless of damage taken.
  • Telekinesis Telekinesis: Automatically blocks any incoming shots, but the push is not strong enough to prevent contact damage.
  • Yum Heart Yum Heart: Since the effect is triggered before taking damage, Panic Button will waste the charge with no benefit unless Isaac is already missing Red health.

In-game footage[]