Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Panic Button is a trinket added in The Binding of Isaac: Repentance.


  • Activates Isaac's active item just before damage would be taken.
    • This still uses the item's charges so if the item is not charged, the trinket will do nothing.
    • Single-use items will be consumed.


  • Because the automatic item activation takes place just before taking would-be damage, this trinket becomes very powerful when holding damage-negating active items.
  • Taking damage from explosions, spikes and spike rocks, spiked/mimic chests, the stomp attacks from Mom and Satan, Whippers and their variants, brimstone lasers (including angel lasers), self-damage items, Devil Beggars, Blood Donation Machines, and Confessionals will not trigger the effect.
  • Super-charged items will use both of their charges. This is NOT an effect by 15►Mom's Box Mom's Box or the Golden Trinket variant.
  • Having 15►Holy Mantle Holy Mantle does not stop the trinket from activating, making you still take damage from items such as 15►IV Bag IV Bag, while bypassing Holy Mantle's shield.


  • Any self-damaging item: Self-damage occurs before enemy damage, making it almost impossible to lose Devil/Angel Room chances.
  • 15►Blood Rights Blood Rights: Triggers the effect on hit, at the cost of every hit making Isaac take full-heart damage.
  • 15►Butter Bean Butter Bean / 15►Wait What? Wait What?: Isaac farts before being hit, knocking back enemies and projectiles.
  • 15►Dull Razor Dull Razor: Activates the item and gives Isaac invincibility frames before being hit, making it work similarly to 15►Holy Mantle Holy Mantle every two rooms. If combined with 15►9 Volt 9 Volt or AAA Battery AAA Battery, works every room, just like Holy Mantle.
  • 15►Glowing Hour Glass Glowing Hour Glass: If consumed with 15►Void Void, Every time Isaac is hit, if it's charged, he is sent back to the previous room without taking damage.
  • 15►How to Jump How to Jump: Makes Isaac immune to contact and tear damage while moving.
  • 15►IV Bag IV Bag: Upon getting hit, activates the IV Bag instead, causing red heart damage and producing money.
  • 15►Kamikaze! Kamikaze!: Causes a highly-damaging explosion to occur every time Isaac is hit, similarly to Swallowed M80 Swallowed M80.
  • 15►Razor Blade Razor Blade: Isaac gains a damage boost every time he's hit, acting similarly to 15►Bloody Lust Bloody Lust except only for the current room, at the cost of every hit making Isaac take full-heart damage.
  • 15►Spin to Win Spin to Win: Has a chance to spawn additional wheels upon taking damage that last only for the current room. This is most likely a bug.
  • 15►Stitches Stitches: Isaac will teleport before damage is taken, making him much harder to hit.
  • Tainted Forgotten Tainted Forgotten: Triggers his active item whenever the body touches something that would damage The Soul, regardless of damage taken.
  • 15►Telekinesis Telekinesis: Automatically blocks any incoming shots, but the push is not strong enough to prevent contact damage.
  • 15►Yum Heart Yum Heart: Since the effect is triggered before taking damage, Panic Button will waste the charge with no benefit unless Isaac is already missing Red health.

In-game footage[]

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