Pandora's Box

Pandora's Box is an unlockable activated item.

Effects[ | ]

Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.

Normal/Hard Mode	Greed Mode	Items/Pickups
Basement / Cellar / Burning Basement I Downpour / Dross I	Basement	2 Soul Hearts
Basement / Cellar / Burning Basement II Downpour / Dross II	Caves Basement / Cellar / Burning Basement	2 Bombs and 2 Keys
Caves / Catacombs / Flooded Caves I Mines / Ashpit I	Depths	1 Boss Room item
Caves / Catacombs / Flooded Caves II Mines / Ashpit II	Womb Caves / Catacombs / Flooded Caves	1 Boss Room item and 2 Soul Hearts
Depths / Necropolis / Dank Depths I Mausoleum / Gehenna I	Sheol	4 Soul Hearts
Depths / Necropolis / Dank Depths II Mausoleum / Gehenna II	The Shop Depths / Necropolis / Dank Depths	20 Pennies
Womb / Utero / Scarred Womb I Corpse I	Ultra Greed Womb / Utero / Scarred Womb	2 Boss Room items
Womb / Utero / Scarred Womb II Corpse II	—	The Bible
???	—	Nothing
Sheol	Sheol	1 Devil Room item and 1 Black Heart
Cathedral	—	1 Angel Room item and 1 Eternal Heart
Dark Room	—	Nothing Unlocks Moving Box
Chest	The Shop / Ultra Greed	1 Penny
The Void	—	Nothing
Home	—	Red Key

Floors affected by Curse of the Labyrinth are counted as the first floor by Pandora's Box.
When playing Greed Mode, the normal Devil Room item pool is still used in Sheol, instead of the Greed Mode Devil Room item pool.
In Greed Mode, it will always generate its 2nd floor drops for each Chapter that is before the Womb, such as 20 pennies in the Depths, etc.
- The Womb is the exception, generating its 1st floor drop: 2 Boss Room items.

The Book of Belial + Birthright as Judas / Dark Judas: In addition to the item's expected reward, spawns one of the following demonic familiars: [[{{{page}}}|Blood Puppy]], [[{{{page}}}|Dark Bum]], [[{{{page}}}|Demon Baby]], [[{{{page}}}|Incubus]], [[{{{page}}}|Lil Abaddon]], [[{{{page}}}|Lil Brimstone]], [[{{{page}}}|Succubus]], or [[{{{page}}}|Twisted Pair]].
Book of Virtues: Spawns floor - 1 regular wisps with no unique effect, up to a maximum of 8. No wisps are spawned on the first floor.
Strange Key: Instead of its normal effect, Pandora's Box spawns six items from a set of item pools. Both items are consumed.
- This will prevent unlocking Moving Box if it hasn't already been unlocked, when used in Dark Room.

Car Battery: No effect.
? Card:
- Will consume both the card and Pandora's Box, but nothing will happen, wasting both of them.
- Will activate Pandora's Box without consuming it, allowing for multiple activations.
- If Isaac is holding Strange Key, using the ? Card will consume the card and trinket, spawning 6 items, but Pandora's Box will not be consumed.

In Greek legend, Pandora's Box is a jar containing all of the evils of the world. It was given to the first woman created, who, in her curiosity, opened it, releasing every evil unto the land. Once the evils were released, the only thing that remained was Elpis, the Spirit of Hope.
Pandora's Box, along with Strange Key, is likely a reference to David Lynch's 2001 film Mulholland Drive.
The rewards for Greed Mode changed in patch v1.06.J168; the rewards given in Caves are instead given in Basement, and so on.
Despite Pandora’s Box’s sprite depicting a keylock, the item does not require a key to open.
In the game files, Pandora's Box's sprite is named Blue Box while Box of Friends' sprite is named Pandora’s Box.