Pandora's Box

"??"
Entity ID	5.100.297
Recharge Time	One time use
Item Pool	Red Chest Shop Shop
Collection Grid	(page 3, column 12, row 3) (page 3, column 2, row 10) (page 3, column 13, row 3)
Unlock Method	Defeat The Lamb as Lazarus

Pandora's Box is an unlockable activated item.

Effect

• Upon use, spawns certain pickups or items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode	Greed Mode	Items/Pickups
Basement I Cellar I Burning Basement I Downpour I Dross I	Basement	2 Soul Hearts
Basement II Cellar II Burning Basement II Downpour II Dross II	Caves Basement Cellar Burning Basement	2 bombs and 2 keys
Caves I Catacombs I Flooded Caves I Mines I Ashpit I	Depths	1 Boss Room item
Caves II Catacombs II Flooded Caves II Mines II Ashpit II	Womb Caves Catacombs Flooded Caves	1 Boss Room item and 2 Soul Hearts
Depths I Necropolis I Dank Depths I Mausoleum I Gehenna I	Sheol	4 Soul Hearts
Depths II Necropolis II Dank Depths II Mausoleum II Gehenna II	The Shop Depths Necropolis Dank Depths	20 Coins
Utero I Womb I Scarred Womb I Corpse I	Ultra Greed Womb Utero Scarred Womb	2 Boss Room items
Utero II Womb II Scarred Womb II Corpse II	---	The Bible
???	---	Nothing
The Void	---	Nothing
Sheol	Sheol	1 Devil Room item and 1 Black Heart
Dark Room	---	Nothing Unlocks Moving Box
Cathedral	---	1 Angel Room item and 1 Eternal Heart
Chest	The Shop Ultra Greed	1 Coin
Home	---	Red Key

Notes

• XL floors count as the first floor for Pandora's Box.
• If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room pool.
• Using the ? Card with Pandora's Box will consume both the card and the item with no additional benefit.
  •  ? Card now activates the item without consuming it, allowing for potential multiple uses. Tarot Cloth, however, has no effect.
• Pandora's Box is not doubled by Car Battery.

Synergies

• Strange Key: Instead of its normal effect, Pandora's Box spawns six items from random pools. Both items are consumed.

Unlockable Achievements

• 

  Moving Box - Use Pandora's Box in Dark Room.

Gallery

• 

  The icon of Pandora's Box as seen on the lower 3DS screen.

Notes

• The rewards for Greed Mode changed in patch v1.06.J168.

Trivia

• In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

Seeds

PC 1TNY 7MJ0 (Curse Room adjacent to spawn)

PC VKPS 2M1F (Shop in 1st floor)

PC 1TNY 7MJO (Second floor curse room)