Pandora's Box

Item Icon
Pickup Quote	"??"
Entity ID	5.100.297
Recharge Time	One time use
Item Pool	Red Chest Shop Shop
Quality	2
Item Tags
Collection Grid	(page 3, column 2, row 10) (page 3, column 12, row 3) (page 3, column 13, row 3)
Unlock Method	Defeat The Lamb as Lazarus

Pandora's Box is an unlockable activated item.

Effects

• Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.

Notes

• Floors affected by Curse of the Labyrinth are counted as the first floor by Pandora's Box.
• When playing Greed Mode, the normal Devil Room item pool is still used in Sheol, instead of the Greed Mode Devil Room item pool.
• In Greed Mode, it will always generate its 2nd floor drops for each Chapter that is before The Shop, such as 20 pennies in the Depths, etc.

Synergies

• Book of Virtues: Spawns floor - 1 regular wisps with no unique effect, up to a maximum of 8. No wisps are spawned on the first floor.
• Strange Key: Instead of its normal effect, Pandora's Box spawns six generally higher quality items from a set of item pools. Both items are consumed.
  • This will prevent unlocking Moving Box if it hasn't already been unlocked, when used in Dark Room.

Interactions

• Car Battery: No effect.
• ? Card: Will consume both the card and Pandora's Box, but nothing will happen, wasting both of them.
  • Will activate Pandora's Box without consuming it, allowing for multiple activations.
  • If Isaac is holding Strange Key, using the ? Card will consume the card and trinket, spawning 6 items, but Pandora's Box will not be consumed.

Unlockable Achievements

• 

  Moving Box - Use Pandora's Box in Dark Room.

Gallery

• 

  The icon of Pandora's Box as seen on the lower 3DS screen.

Trivia

• In Greek legend, Pandora's Box is a jar containing all of the evils of the world. It was given to the first woman created, who, in her curiosity, opened it, releasing every evil unto the land. Once the evils were released, the only thing that remained was Elpis, the Spirit of Hope.
• Pandora's Box, along with Strange Key, is likely a reference to David Lynch's 2001 film Mulholland Drive.
• The rewards for Greed Mode changed in patch v1.06.J168; the rewards given in Caves are instead given in Basement, and so on.
• Despite Pandora’s Box’s sprite depicting a keylock, the item does not require a key to open.

Seeds

PC 1TNY 7MJ0 ( Curse Room adjacent to spawn)

PC VKPS 2M1F ( Shop in 1st floor)

PC 1TNY 7MJO (Second floor Curse Room)

The Binding of Isaac: Rebirth
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