Binding of Isaac: Rebirth Wiki
Advertisement

Pandora's Box is an unlockable activated item.

Effects[ | ]

  • Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.
Normal/Hard Mode (except in Rebirth) Greed Mode Items/Pickups
BasementBasement / CellarCellar / (except in Rebirth)Burning BasementBurning Basement I
(in Repentance)DownpourDownpour / (in Repentance)DrossDross I
(in Afterbirth) BasementBasement 2 Soul HeartSoul Hearts
BasementBasement / CellarCellar / (except in Rebirth)Burning BasementBurning Basement II
(in Repentance)DownpourDownpour / (in Repentance)DrossDross II
(in Afterbirth)CavesCaves
(in Afterbirth † and Repentance)BasementBasement / (in Repentance)CellarCellar / (in Repentance)Burning BasementBurning Basement
2 BombBombs and 2 KeyKeys
CavesCaves / CatacombsCatacombs / (except in Rebirth)Flooded CavesFlooded Caves I
(in Repentance)MinesMines / (in Repentance)AshpitAshpit I
(in Afterbirth) DepthsDepths 1 Boss Room item
CavesCaves / CatacombsCatacombs / (except in Rebirth)Flooded CavesFlooded Caves II
(in Repentance)MinesMines / (in Repentance)AshpitAshpit II
(in Afterbirth)WombWomb
(in Afterbirth † and Repentance)CavesCaves / (in Repentance)CatacombsCatacombs / (in Repentance)Flooded CavesFlooded Caves
1 Boss Room item and 2 Soul HeartSoul Hearts
DepthsDepths / NecropolisNecropolis / (except in Rebirth)Dank DepthsDank Depths I
(in Repentance)MausoleumMausoleum / (in Repentance)GehennaGehenna I
(in Afterbirth)SheolSheol 4 Soul HeartSoul Hearts
DepthsDepths / NecropolisNecropolis / (except in Rebirth)Dank DepthsDank Depths II
(in Repentance)MausoleumMausoleum / (in Repentance)GehennaGehenna II
(in Afterbirth)The ShopThe Shop
(in Afterbirth † and Repentance) (in Afterbirth † and Repentance)DepthsDepths / (in Repentance)NecropolisNecropolis / (in Repentance)Dank DepthsDank Depths
20 PennyPennies
WombWomb / UteroUtero / (except in Rebirth)Scarred WombScarred Womb I
(in Repentance)CorpseCorpse I
(in Afterbirth)Ultra GreedUltra Greed
(in Afterbirth † and Repentance)WombWomb / (in Repentance)UteroUtero / (in Repentance)Scarred WombScarred Womb
2 Boss Room items
WombWomb / UteroUtero / (except in Rebirth)Scarred WombScarred Womb II
(in Repentance)CorpseCorpse II
Collectible The Bible iconThe Bible
(except in Rebirth)?????? Nothing
SheolSheol (in Afterbirth † and Repentance)SheolSheol 1 Devil Room item and 1 Black HeartBlack Heart
CathedralCathedral 1 Angel Room item and 1 Eternal HeartEternal Heart
Dark RoomDark Room Nothing
(in Afterbirth † and Repentance) Unlocks Collectible Moving Box iconMoving Box
ChestChest (in Afterbirth † and Repentance)The ShopThe Shop / (except in Rebirth)Ultra GreedUltra Greed 1 PennyPenny
(in Afterbirth † and Repentance)The VoidThe Void Nothing
(in Repentance)HomeHome Collectible Red Key iconRed Key

Notes[ | ]

Synergies[ | ]

Interactions[ | ]

  • (except in Rebirth)Collectible Car Battery iconCar Battery: No effect.
  • (except in Rebirth)? Card? Card:
    • (in Afterbirth and Afterbirth †) Will consume both the card and Pandora's Box, but nothing will happen, wasting both of them.
    • (in Repentance) Will activate Pandora's Box without consuming it, allowing for multiple activations.
    • (in Repentance) If Isaac is holding Strange KeyStrange Key, using the ? Card will consume the card and trinket, spawning 6 items, but Pandora's Box will not be consumed.

In-game Footage[ | ]

Unlockable Achievements[ | ]

Gallery[ | ]

Trivia[ | ]

  • In Greek legend, Pandora's Box is a jar containing all of the evils of the world. It was given to the first woman created, who, in her curiosity, opened it, releasing every evil unto the land. Once the evils were released, the only thing that remained was Elpis, the Spirit of Hope.
  • Pandora's Box, along with (in Repentance)Strange KeyStrange Key, is likely a reference to David Lynch's 2001 film Mulholland Drive.
  • The rewards for Greed Mode changed in patch v1.06.J168; the rewards given in CavesCaves are instead given in BasementBasement, and so on.
  • Despite Pandora’s Box’s sprite depicting a keylock, the item does not require a key to open.
  • In the game files, Collectible Pandora's Box iconPandora's Box's sprite is named Blue Box while (except in Rebirth)Collectible Box of Friends iconBox of Friends' sprite is named Pandora’s Box.


Advertisement