Binding of Isaac: Rebirth Wiki
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Pandora's Box is an unlockable activated item.

Effects[]

  • Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use.
Normal/Hard Mode Added in Afterbirth Greed Mode Items/Pickups
Basement Basement / Cellar Cellar / Added in Afterbirth Burning Basement Burning Basement / Added in Repentance Downpour Downpour / Added in Repentance Dross Dross I Added in Afterbirth / Removed in Afterbirth † Basement Basement 2 Soul Heart Soul Hearts
Basement Basement / Cellar Cellar / Added in Afterbirth Burning Basement Burning Basement / Added in Repentance Downpour Downpour / Added in Repentance Dross Dross II Added in Afterbirth / Removed in Afterbirth † Caves Caves / Added in Afterbirth † Basement Basement / Added in Repentance Cellar Cellar / Added in Repentance Burning Basement Burning Basement 2 Bomb Bombs and 2 Key Keys
Caves Caves / Catacombs Catacombs / Added in Afterbirth Flooded Caves Flooded Caves / Added in Repentance Mines Mines / Added in Repentance Ashpit Ashpit I Added in Afterbirth / Removed in Afterbirth † Depths Depths 1 Boss Room item
Caves Caves / Catacombs Catacombs / Added in Afterbirth Flooded Caves Flooded Caves / Added in Repentance Mines Mines / Added in Repentance Ashpit Ashpit II Added in Afterbirth / Removed in Afterbirth † Womb Womb / Added in Afterbirth † Caves Caves / Added in Repentance Catacombs Catacombs / Added in Repentance Flooded Caves Flooded Caves 1 Boss Room item and 2 Soul Heart Soul Hearts
Depths Depths / Necropolis Necropolis / Added in Afterbirth Dank Depths Dank Depths / Added in Repentance Mausoleum Mausoleum / Added in Repentance Gehenna Gehenna I Added in Afterbirth / Removed in Afterbirth † Sheol Sheol 4 Soul Heart Soul Hearts
Depths Depths / Necropolis Necropolis / Added in Afterbirth Dank Depths Dank Depths / Added in Repentance Mausoleum Mausoleum / Added in Repentance Gehenna Gehenna II Added in Afterbirth / Removed in Afterbirth † The Shop The Shop / Added in Afterbirth † Depths Depths / Added in Repentance Necropolis Necropolis / Added in Repentance Dank Depths Dank Depths 20 Penny Pennies
Womb Womb / Utero Utero / Added in Afterbirth Scarred Womb Scarred Womb / Added in Repentance Corpse Corpse I Added in Afterbirth / Removed in Afterbirth † Ultra Greed Ultra Greed / Added in Afterbirth † Womb Womb / Added in Repentance Utero Utero / Added in Repentance Scarred Womb Scarred Womb 2 Boss Room items
Womb Womb / Utero Utero / Added in Afterbirth Scarred Womb Scarred Womb / Added in Repentance Corpse Corpse II --- The Bible The Bible
Added in Afterbirth ??? ??? --- Nothing
Added in Afterbirth † The Void The Void --- Nothing
Sheol Sheol Added in Afterbirth † Sheol Sheol 1 Devil Room item and 1 Black Heart Black Heart
Dark Room Dark Room --- Nothing
Added in Afterbirth † Unlocks Moving Box Moving Box
Cathedral Cathedral --- 1 Angel Room item and 1 Eternal Heart Eternal Heart
Chest Chest Added in Afterbirth † The Shop The Shop / Ultra Greed Ultra Greed 1 Penny Penny
Added in Repentance Home Home --- Red Key Red Key

Notes[]

Synergies[]

  • Added in RepentanceBook of Virtues Book of Virtues: Spawns floor - 1 regular wisps with no unique effect, up to a maximum of 8. No wisps are spawned on the first floor.
  • Added in RepentanceStrange Key Strange Key: Instead of its normal effect, Pandora's Box spawns six generally higher quality items from a set of item pools. Both items are consumed.

Interactions[]

  • Added in AfterbirthCar Battery Car Battery: No effect.
  • Added in Afterbirth / Removed in Repentance? Card ? Card: Will consume both the card and Pandora's Box, but nothing will happen, wasting both of them.
    • Added in Repentance Will activate Pandora's Box without consuming it, allowing for multiple activations.

In-game Footage[]

Unlockable Achievements[]

Gallery[]

Trivia[]

  • In Greek legend, Pandora's Box is a jar containing all of the evils of the world. It was given to the first woman created, who, in her curiosity, opened it, releasing every evil unto the land. Once the evils were released, the only thing that remained was Elpis, the Spirit of Hope.
  • Pandora's Box, along with Added in RepentanceStrange Key Strange Key, is likely a reference to David Lynch's 2001 film Mulholland Drive.
  • The rewards for Greed Mode changed in patch v1.06.J168; the rewards given in Caves Caves are instead given in Basement Basement, and so on.

Seeds[]

PC Normal and hard modes only 1TNY 7MJ0 (Curse Room Curse Room adjacent to spawn)

PC Added in Afterbirth † Normal mode only VKPS 2M1F (Shop Shop in 1st floor)

PC Added in Afterbirth † Hard mode only 1TNY 7MJO (Second floor Curse Room Curse Room)


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