Binding of Isaac: Rebirth Wiki

PHD is a passive item.


  • Identifies all pills upon pickup.
  • Spawns a pill.
  • Replenishes 2 Red Heart Red Hearts.
  • Adds 0-2 coins to the payout every time you use a Blood Donation Machine.png Blood Donation Machine or IV Bag IV Bag.
    • In hard mode, adds exactly 1 coin to the payout.
  • Converts some "bad" pills into their "good" counterparts or removes their bad effects:
Pill Changes Into
Stat down pill Stat up pill
Amnesia I can see forever!
Added in Afterbirth † ??? Telepills
Added in Afterbirth † Addicted Percs!
Added in Afterbirth † I'm Excited!!! I'm Drowsy...
Added in Afterbirth † Paralysis Pheromones
Added in Afterbirth † Retro Vision I can see forever!
Added in Afterbirth † R U A Wizard? Power Pill!
Added in Afterbirth † X-Lax Something's wrong...
Removed in Repentance Bad Trip Full Health
Added in Repentance Bad Trip Balls of Steel
Added in Repentance Experimental Pill Only grants a stat up
Added in Repentance Gold Pill Only has positive effects
48 Hour Energy
Bad Gas
Bombs are Key
Explosive Diarrhea
I can see forever!
I Found Pills
Lemon Party
Pretty Fly
Added in Afterbirth Friends Till the End!
Added in Afterbirth Infested!
Added in Afterbirth Infested?
Added in Afterbirth One makes you larger
Added in Afterbirth One makes you small
Added in Afterbirth Percs!
Added in Afterbirth Power Pill!
Added in Afterbirth Re-Lax
Added in Afterbirth / Removed in Afterbirth † ???
Added in Afterbirth / Removed in Afterbirth † Addicted!
Added in Afterbirth / Removed in Afterbirth † Retro Vision
Added in Afterbirth † Feels Like I'm Walking on Sunshine!
Added in Afterbirth † Gulp!
Added in Afterbirth † Horf!
Added in Afterbirth † Something's Wrong...
Added in Afterbirth † Vurp!
Removed in Afterbirth † Paralysis
Removed in Afterbirth † R U A Wizard?


  • Bad pills already obtained/dropped will be converted to their "good" counterparts.
  • If PHD is lost in any way, such as rerolling by the D4 D4 or a Dice Room Dice Room, or dropping it as Added in Repentance Tainted Isaac Tainted Isaac, pills will remain fully identified, but negative pills will not be converted.
  • Added in Afterbirth † Performing a RERUN with a character that held PHD will still prevent negative pills from spawning, but will no longer identify pills until used.
  • As bad pills will turn into good pills, it is possible for two different colored pills to have the same effect.


In-game Footage[]


  • PHD stands for Doctor of Philosophy (Ph.D.) and it's the most common degree at the highest academic level awarded following a course of study. Doctorates can be in any study, in Isaac's case, medicine.


PC 49BH 7C4X (Treasure Room adjacent to spawn)

PC Added in Repentance D77Y 9NM3 (Treasure Room adjacent to spawn)

Vita F1MK 02T4 (Treasure Room adjacent to spawn)

Switch 1RY7 20CH (First floor Shop, half off)