Oh Crap

Upon picking up 3 items from the following list, Isaac will heal half of a red heart each time a pile of poop is destroyed.

Activated Collectibles[]

Name	ID	Icon	Quote	Description	Quality
Flush!	5.100.291		...	Turns all non-boss monsters in the room into poop. Instantly kills poop-themed bosses.	1
The Poop	5.100.36		Plop!	Spawns a pile of poop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop.	0

Repentance only:

Name	ID	Icon	Quote	Description	Quality
Brown Nugget	5.100.504		Friendly fly	Spawns a stationary fly turret that fires tears at nearby enemies.	0

Name	ID	Quote	Description	Quality
E. Coli	5.100.236	Turdy touch	Enemies that touch Isaac are transformed into poop.	1
Dirty Mind	5.100.576	Filthy friends	Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.	2
Montezuma's Revenge	5.100.680	Oh no...	While firing, Isaac charges up a short-ranged Brimstone-like diarrhea beam that shoots behind him.	3

Repentance only:

Name	ID	Quote	Description	Quality
Butt Bombs	5.100.209	Toxic blast +5 bombs	+5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.	2
Skatole	5.100.9	Fly love	Flies become harmless or less dangerous depending on the type.	0
No. 2	5.100.378	Uh oh...	Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.	2
Hallowed Ground	5.100.543	Portable sanctuary	Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots.	1

Despite being poop-themed, Skatole, Butt Bombs, and No. 2 do not count towards the transformation.
Despite being poop-themed, IBS does not count towards the transformation.
Poop created with Flush! and E. Coli do not heal Isaac when he has this transformation.
Oh Crap! is useless for any character that cannot have Red Heart Containers such as ???, The Lost, Dark Judas, Keeper, Tainted ???, Tainted Keeper, Tainted Bethany, Tainted Judas, and Tainted Lost.
The Scat Man and High Brow challenges starts with this transformation.