Gimpy / Old Bandage / Fanny Pack: Further increase the chance of hearts appearing after use allowing the generation of even more random pickups.
Tainted Keeper: Coins generated by killing enemies will be replaced by random pickups, however they will still disappear after a short time.
Lucky Rock: 26.6% of rocks exploded will drop random pickups.
Guppy's Tail: The keys needed to open gold chests will be converted to other pickups. However, the large quantities of coins generated from chests can be turned into many random pickups. Dropping Nuh Uh! at the start of the floor and then picking it back up to collect random pickups later allows for keys to collected but still gain large quantities of random pickups. Due to the large amount of pills and bombs generated, having the Bombs are Key pill effect in the pool may allow you to turn a surplus of bombs into a surplus of keys as needed.