Nicalis, Inc. is an indie video game publisher, famous for developing and publishing The Binding of Isaac: Rebirth and its DLCs- Afterbirth, Afterbirth+ and Repentance. It was founded by Tyrone Rodriguez in 2007.
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 People
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| Lead | Edmund McMillen • Florian Himsl |
| Nicalis, Inc. | Tyrone Rodriguez |
| Music | Danny Baranowsky • RIDICULON |
 The Binding of Isaac: Rebirth
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 Achievements
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 Attributes
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 Bosses
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 Cards and Runes
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 Challenges
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 Chapters
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 Characters
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 Co-op
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 Items
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 Item pools
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 Monsters
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 Objects
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 Pickups
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 Pills
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 Rooms
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 Seeds
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 Transformations
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 Trinkets
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