Mysterious Liquid

"Toxic Splash Damage"

Item ID
5.100.317
Character Appearance
Tear Appearance


Collection Grid
(page 3, column 12, row 4)
(page 4, column 2, row 2)
(page 3, column 13, row 4)



Mysterious Liquid is a passive item.
Effect[edit | edit source]
- Tears leave a small, short-lasting pool of creep upon hitting an enemy or when their range is depleted.
- The creep deals 1 damage per tick or 30 damage per second.
Synergies[edit | edit source]
Compound Fracture/
Cricket's Body/
The Parasite: Each split tear leaves a pool of creep, creating lots of creep.
Explosivo: Generates an explosion-sized pool of creep whenever the explosivo tear goes off.
Flat Stone: Every time tears bounce, creep spawns.
Mom's Knife: Creates a line of creep behind the knife as it shoots towards enemies.
Tech X: The laser ring often spawns pools of liquid when it hits enemies.
Tech.5: The laser spawns pools of liquid always when it hits obstacles and occasionally on enemies.
Technology 2: The laser rapidly spawns pools of liquid on hitting both obstacles and enemies.
Trisagion: Causes a large trail of creep. The effect stacks, which causes heavy damage (even to Hush).
Interactions[edit | edit source]
Brimstone: Overrides Mysterious Liquid.
The beam spawns pools of liquid always when it hits obstacles and often on enemies.
- Azazel: Pools of liquid are spawned at the end of Azazel's shorter brimstone beam.
Dr. Fetus/
Epic Fetus/
Ipecac: Overrides Mysterious Liquid.
: Explosions caused by these items will cause a large pool of creep where the explosion occurred.
Fire Mind: Mysterious Liquid removes explosion chance, but fire damage over time is preserved.
Tears not only correctly retain explosion chance, but if the explosion occurs, creep generates in the entire explosion radius.
Haemolacria: Only the main tear spawns creep.
Lachryphagy: Only the burst tears spawns creep.
Lost Contact: Overrides Mysterious Liquid.
The combination works as expected, with tears spawning liquid even when stopping enemy shots.
The Ludovico Technique: Mysterious Liquid's graphical effect remains, but no creep is dropped because the tear never falls.
Pools the size of the tear constantly form on the ground dealing large amounts of damage to any non-flying enemy inside the tear.
- Piercing tears: Tears will not leave creep when they hit and pass through an enemy, and will only leave creep when they hit an obstacle or run out of range.
- Spectral tears: Tears only spawn creep after they land, not while passing through obstacles.
Strange Attractor: Overrides Mysterious Liquid.
The combination works as expected.
Technology: Overrides Mysterious Liquid.
The laser spawns pools of liquid always when it hits obstacles and occasionally on enemies.
In-game Footage[edit | edit source]
Seeds[edit | edit source]
PC ABP0 1DJA (Treasure Room adjacent to spawn)
PC QXAX ZJYL (Treasure Room adjacent to spawn)
PS4 V8ZG HD31 (First floor Treasure Room)
Vita 2J39 EANS (Treasure Room adjacent to spawn)
Switch HLL1 RW2R (Treasure Room adjacent to spawn)
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