Binding of Isaac: Rebirth Wiki

Mutant Spider is a passive item.

Effects[ | ]

  • Isaac fires 4 tears at the same time.
  • (except in Repentance) Tears down: (Delay * 2.1) + 3.
  • (in Repentance) Tears fired per second * 0.42.
  • (in Afterbirth † and Repentance) This item belongs to the Spider BabySpider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.

Notes[ | ]

Synergies[ | ]

  • (in Repentance)Collectible Abyss iconAbyss: When Isaac uses Abyss to absorb Mutant Spider it creates four locusts instead of one.
  • Collectible Brimstone iconBrimstone: Shoots 4 beams at once, dealing massive damage.
  • (except in Repentance) Collectible Cursed Eye iconCursed Eye: Shoots 4 shots out of each eye, for a total of 16 tears when fully charged.
  • Collectible Doctor's Remote iconDoctor's Remote/Collectible Epic Fetus iconEpic Fetus: Replaces the single missile strike with a barrage of four consecutive missiles.
  • (in Afterbirth and Afterbirth †)Collectible The Inner Eye iconThe Inner Eye: Shoots 7 tears with no further decrease in fire rate.
    • (in Repentance) Shoots 5 tears with no further decrease in fire rate.
  • (in Afterbirth and Afterbirth †)Collectible Mutant Spider iconMutant Spider: Fires 8 tears with no further decrease in fire rate.
    • (in Repentance) Each copy of the item adds +2 tears, up to the maximum of 16.
  • Collectible Polyphemus iconPolyphemus: Tear rate is not lowered further. Damage is increased by a flat +5 instead of normal Polyphemus boost.
  • (except in Rebirth)Collectible Tractor Beam iconTractor Beam: All tears are fired along the beam.

Interactions[ | ]

  • (in Rebirth and Afterbirth) Collectible 20 20 icon20/20: Overridden by Mutant Spider.
    • (in Afterbirth †) Shoots 6 tears.
    • (in Repentance) Removes the fire rate penalty while reducing damage to 80%. Additional copies will add one additional tear with no further change to damage/fire rate.
  • (in Afterbirth and Afterbirth †) Character Keeper iconKeeper: Fires 7 tears with significantly decreased fire rate.
    • (in Repentance) Fires 5 tears with significantly decreased fire rate.
  • (in Repentance) Character Tainted Keeper iconTainted Keeper: Fires 6 tears with significantly decreased fire rate.
  • Collectible The Ludovico Technique iconThe Ludovico Technique: The tear gains 3 orbiting tears.
  • Collectible Loki's Horns iconLoki's Horns: Only occasionally fires one tear in the other three directions.
  • (in Rebirth and Afterbirth) Collectible Mom's Eye iconMom's Eye: No effect.
    • (in Afterbirth † and Repentance) Fires three shots out of each eye.
  • Collectible Monstro's Lung iconMonstro's Lung: Adds 7 tears to the barrage with a significant decrease in fire rate.
  • (in Afterbirth † and Repentance)Collectible Pupula Duplex iconPupula Duplex + Collectible Lachryphagy iconLachryphagy: The four shots instantly fuse and burst.
  • Collectible Sad Bombs iconSad Bombs / (in Afterbirth † and Repentance)Collectible Varicose Veins iconVaricose Veins / (in Repentance)Collectible It Hurts iconIt Hurts: No effect.
  • (except in Repentance)Collectible The Wiz iconThe Wiz: Four shots are fired in each direction.
    • (in Repentance): Three shots are fired in each direction.

In-game Footage[ | ]

Trivia[ | ]

  • It might be a nod to Spiderman and the general trope of gaining superpowers by being bitten by a radiative animal.
  • Numerous fans refer to this item by its quote instead of its true name.