Mutant Spider is a passive item.
Effects[ | ]
- Isaac fires 4 tears at the same time.
Tears down: (Delay * 2.1) + 3.- Tears fired per second * 0.42.
- This item belongs to the Spider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.
Tears down: (Delay * 2.1) + 3.
Tears fired per second * 0.42.
This item belongs to the 
Notes[ | ]
- Mutant Spider is a special item.
- The maximum number of tears per volley that can be reached by combining and/or duplicating 20/20, The Inner Eye, Mutant Spider and The Wiz is 16, or 20 with the Keeper.
The maximum number of tears per volley that can be reached by combining and/or duplicating 
Synergies[ | ]
- 20/20: Shoots 6 tears.
- Removes the fire rate penalty while reducing damage to 80%. Additional copies will add one additional tear with no further change to damage/fire rate.
- Abyss: When Isaac uses Abyss to absorb Mutant Spider it creates four locusts instead of one.
- Brimstone: Shoots 4 beams at once.
- Cursed Eye: Shoots 4 shots out of each eye, for a total of 16 tears when fully charged.
- Doctor's Remote/Epic Fetus: Replaces the single missile strike with a barrage of four consecutive missiles.
- The Inner Eye: Shoots 7 tears with no further decrease in fire rate.
- Shoots 5 tears with no further decrease in fire rate.
- Monstro's Lung: Adds 7 tears to the barrage with a significant decrease in fire rate.
- Mutant Spider: Fires 8 tears with no further decrease in fire rate.
- Each copy of the item adds +2 tears, up to the maximum of 16.
- Polyphemus: Tear rate is not lowered further. Damage is increased by a flat +5 instead of normal Polyphemus boost.
- Tractor Beam: All tears are fired along the beam.
- The Wiz: Four shots are fired in each direction.
- : Three shots are fired in each direction.
Interactions[ | ]
- 20/20: Overridden by Mutant Spider.
- Keeper: Fires 7 tears with significantly decreased fire rate.
- Fires 5 tears with significantly decreased fire rate.
- Tainted Keeper: Fires 6 tears with significantly decreased fire rate.
- The Ludovico Technique: The tear gains 3 orbiting tears.
- Loki's Horns: Only occasionally fires one tear in the other three directions.
- Mom's Eye: No effect.
- Fires three shots out of each eye.
- Pupula Duplex + Lachryphagy: The four shots instantly fuse and burst.
- Sad Bombs / Varicose Veins / It Hurts: No effect.
In-game Footage[ | ]
Trivia[ | ]
- It might be a nod to Spiderman and the general trope of gaining superpowers by being bitten by a radiative animal.
- This item is often called "Quad Shot" by the community instead of Mutant Spider. It shares this with Dead Cat, which is popularly called 9 Lives.
 Spider Items
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| Items |
 The Binding of Isaac: Rebirth
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