Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Mr. ME! is an unlockable activated item added in Booster Pack #3.


  • Summons a ghost near Isaac that will follow him around, and summons a controllable blue crosshair. After a few seconds, the crosshair disappears, and the ghost will act depending on what the crosshair was targeting:


  • Removed in Repentance Stealing an item from a shop will restock it with another item. This happens even if Isaac does not have Restock Restock.
    • Added in Repentance Stealing shop items will never restock them, even if Isaac does have Restock Restock. This includes Greed Mode.
    • Added in Repentance Stealing from a black market will not restock items, as they work like devil deals.
  • Added in RepentanceAllows The Lost to take more than one devil deal.
  • If the crosshair is not targeting anything when the crosshair disappears, the ghost will interact with the object closest to the crosshair.
    • This can be used to check for secret rooms on multiple walls at once.
  • If the room has nothing to interact with, the ghost will disappear without doing anything.
  • The ghost cannot pick up sticky nickels and will disappear upon touching them.
  • The ghost can press the button in Greed Mode, allowing waves to be stopped without taking damage.
  • The ghost can open chests in Challenge Rooms without triggering the room.
  • Unlike chests, stealing an item pedestal from a Challenge Room will trigger the waves to spawn upon picking up the stolen item.
  • In rooms with multiple pedestal items where only one can be taken, if the ghost is carrying a pedestal while Isaac picks up a different pedestal item, the ghost will disappear. This prevents taking both items for free.
  • Mr. Me can open the door to the Mausoleum Mausoleum/Gehenna Gehenna without paying hearts.
  • Using Mr. ME! with Tainted Forgotten does not work as displayed. Mr. ME! will not follow the crosshair, instead it will target where the Forgotten is thrown.


  • Added in RepentanceBook of Virtues Book of Virtues: Spawns a wisp that looks like a face in the middle ring. The wisp cannot shoot. If the current room is cleared, the wisps automatically move toward and unlock chests and special room doors, destroying themselves in the process. The wisps can open ANY locked doors, including the ones to Mega Satan, the Ascent, and Corpse. Stone/Mega Chests are unaffected.
  • Car Battery Car Battery: May sometimes glitch pedestal items, resulting in Isaac being unable to pick them up without leaving and re-entering the room. Otherwise has no effect.
  • Sack Head Sack Head: If Mr. ME! successfully stole a consumable from the shop, there is a chance he will drop a sack instead.

In-game Footage[]


Bug Bug! If the Devil Room or Angel Room disappears after leaving it, using Mr. ME! will still attempt to unlock the doorway back to it. This allows you to move through the wall as if there were a door there, but you will not be able to enter the Devil Room or Angel Room.
Bug Bug! If used while shooting with Marked Marked, the crosshair will continue straight in the first direction Isaac shot at, and cannot be controlled until Marked is deactivated.
Bug Bug! Mr. Me is able to damage Mom's doors even when no body part is sticking out of them, Mom's Heart and It Lives while they're withdrawn, and Isaac and Hornfel while they're off screen. He never loses them as a valid target, eventually killing the boss.
Bug Bug! Attempting to use Mr. ME! to open alt. chapter doors will sometimes crash the game.
Bug Bug! Attempting to use Mr. ME! to buy a devil deal item in the boss room (after the use of the Satanic Bible Satanic Bible) crashes the game.
Bug Bug! Using Mr. ME! right before the Tainted Lazarus Tainted Lazarus transformation will lead to the ghost standing in place until the room is left.


  • Mr. ME! is based on this Steam Workshop item by Jean-Alphonse, originally known as Mr. Meeseeks.
  • Mr. ME! is a reference to Mr. Meeseeks from Rick and Morty, which spawn from a box and stop existing after completing their given task.
    • The pickup quote also refers to a catchphrase used by Mr. Meeseeks.


PC M34T 439X (First floor shop)