Summons a ghost near Isaac that will follow him around, and summons a controllable blue crosshair. After a few seconds, the crosshair disappears, and the ghost will act depending on what the crosshair was targeting:
Items, pickups, trinkets, brown/red/spiked/megachests: Brings it to Isaac. Works in shops, devil deals, and black markets as well, making them effectively free. Stealing an item has a 50% chance to fail. If that happens, a buzzer sound will play out and the ghost will disappear without doing anything.
Enemies: Attacks the enemy until it dies or can no longer be targeted due to a form change or similar cause. The ghost does 3 damage per tick, for 9 damage per second. BFFS! does not increase this damage.
Doors: Opens the door, even if it is locked. Functions the same as Dad's Key when being used in this way. This includes the door to Mega Satan, exiting Hush's room, and exiting Boss Rush.
This does not work on A Strange Door. However, it does work on doors leading to alternate path levels.
This does not work on the hidden closet in Home to unlock the tainted characters.
Secret room entrances: Explodes, opening the entrance.
Stealing an item from a shop will restock it with another item. This happens even if Isaac does not have Restock.
Stealing shop items will never restock them, even if Isaac does have Restock. This includes Greed Mode.
Stealing from a black market will not restock items, as they work like devil deals.
If the crosshair is not targeting anything when the crosshair disappears, the ghost will interact with the object closest to the crosshair.
This can be used to check for secret rooms on multiple walls at once.
If the room has nothing to interact with, the ghost will disappear without doing anything.
The ghost cannot pick up sticky nickels and will disappear upon touching them.
The ghost can press the button in Greed Mode, allowing waves to be stopped without taking damage.
The ghost can open chests in Challenge Rooms without triggering the room.
Unlike chests, stealing an item pedestal from a Challenge Room will trigger the waves to spawn upon picking up the stolen item.
In rooms with multiple pedestal items where only one can be taken, if the ghost is carrying a pedestal while Isaac picks up a different pedestal item, the ghost will disappear. This prevents taking both items for free.
When used against Isaac, the ghost will still try to chase the boss even when he flies away.
Mr. Me can open the door to the Mausoleum/Gehenna without paying hearts.
Interactions[]
Car Battery: May sometimes glitch pedestal items, resulting in Isaac being unable to pick them up without leaving and re-entering the room. Otherwise has no effect.
Sack Head: If Mr. ME! successfully stole a consumable from the shop, there is a chance he will drop a sack instead.
In-game Footage[]
Bugs[]
Bug!
If the Devil Room or Angel Room disappears after leaving it, using Mr. ME! will still attempt to unlock the doorway back to it. This allows you to move through the wall as if there were a door there, but you will not be able to enter the Devil Room or Angel Room.
Bug!
If used while shooting with Marked, the crosshair will continue straight in the first direction Isaac shot at, and cannot be controlled until Marked is deactivated.
Bug!
Attempting to use Mr. ME! to open alt. chapter doors will sometimes crash the game.
Bug!
Attempting to use Mr. ME! to buy a devil deal item in the boss room (after the use of the Satanic Bible) crashes the game.
Bug!
Using Mr. ME! right before the Tainted Lazarus transformation will lead to the ghost standing in place until the room is left.
Trivia[]
Mr. ME! is based on this Steam Workshop item by Jean-Alphonse, originally known as Mr. Meeseeks.
Mr. ME! is a reference to Mr. Meeseeks from Rick and Morty, which spawn from a box and stop existing after completing their given task.
The pickup quote also refers to a catchphrase used by Mr. Meeseeks.
BFFS! does not increase this damage.
This does not work on 
Stealing an item from a shop will restock it with another item. This happens even if Isaac does not have 
Bug!
Marked, the crosshair will continue straight in the first direction Isaac shot at, and cannot be controlled until Marked is deactivated.
Satanic Bible) crashes the game.
Tainted Lazarus transformation will lead to the ghost standing in place until the room is left.
The Binding of Isaac: Rebirth 
Achievements
Attributes
Bosses
Cards and Runes
Challenges
Chapters
Characters
Co-op
Items
Item pools
Monsters
Objects
Pickups
Pills
Rooms
Seeds
Transformations
Trinkets
