PLEASE NOTE:
This wiki contains The Binding of Isaac: Repentance content, including potentially heavy spoilers.
All information is welcome to be added and is not hidden, but if you still wish to browse, you can activate the DLC filter (at the top right of any article) according to your game version to minimize your exposure to Repentance additions and changes.

Monsters

Monsters refers to the many antagonistic creatures the player will encounter throughout the game.

Ambox important.svg This article is incomplete. Please help to improve it, or discuss the issue on the talk page.

Issues: Is missing multiple Repentance enemies.

Most monsters (with few exceptions) will damage Isaac by either touching him or shooting him with projectiles. Less frequently, monsters will spawn additional, lesser monsters, spread creep, or attempt to affect the player's movement. Along with the more common variety of monsters, champion versions can be found lurking about. These monsters are often like their common counterparts, but have a color tint or size change and drop basic pickups on death. There are also champion versions of most bosses.

There are 196 naturally spawning monsters in total. 40 of them were added in Afterbirth and 21 were added in Afterbirth † (13 were added in Booster Packs). Almost all of these naturally spawning entities are featured in the Dlc a† indicator.png Bestiary, with the exceptions being the Rag Man's Ragling and Suction Pitfall.

Monster List

Error: The given entity ("Clickety Clack") does not exist.
Entity ID Description
Gaper
Gaper.png
10.1 Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Frowning Gaper
Frowning Gaper.png
10.0 Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes and pursue Isaac faster. Usually turns into a Pacer or a Gusher upon death.
Flaming Gaper
Flaming Gaper.png
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10.2 Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Cyclopia
Cyclopia.png
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284.0 Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Faceless
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264.0 Walks towards Isaac, dealing contact damage. Shoots 6 blood shots in a hexagonal shape.
Fanatic
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272.0 Shoots two purple, rotating tears like a Ragling.
Tainted Faceless
Tainted Faceless.png
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827.1 Tainted Faceless walk towards towards Isaac while releasing 6 blood shots in a hexagonal shape every few seconds. They essentially behave like Faceless with higher health.
Deep Gaper
Deep Gaper.png
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241.0 Emerges off the floor once all previous enemies have been killed, then proceeds to chase Isaac like a normal Gaper.
Blurb
Blurb.png
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241.1 Walks slowly towards Isaac. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly.
Gurgle
Gurgle.png
87.0 Walks towards Isaac, firing Ipecac shots at him. Can turn into a Splasher upon death.
Crackle
Crackle.png
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87.0 Walks toward Isaac, spitting balls of fire that create lines of fire in the cardinal directions on impact.
Nulls
Nulls.png
252.0 Act like faster Frowning Gapers, and phase in and out of visibility. When Isaac gets near, they open their eyes and pursue Isaac faster.
Blue Gaper
Blue Gaper.png
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297.0 Walks towards Isaac, dealing contact damage.
Wraith
Wraith.png
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241.2 Walks toward Isaac, dealing contact damage. Can only be seen through its reflection and ripples it leaves in the water as it moves.
Greed Gaper
Greed Gaper.png
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299.0 Walks towards Isaac, dealing contact damage.
Rotten Gaper
Rotten Gaper.png
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10.3 Walks toward Isaac, dealing contact damage. Movement varies depending on its facial expression. Occasionaly summons Small Maggots upon death.
Twitchy
Twitchy.png
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10.4 Alternates between walking toward and repeatedly leaping towards Isaac.
Level 2 Gaper
Level 2 Gaper.png
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284.0 Walks towards Isaac, dealing contact damage. Usually turns into a Level 2 Horf and a Level 2 Gusher upon death.
Dump
Dump.png
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310.0 Slides around, leaving trails of Brown Creep. When hit enough, its head comes off while its body spews out brown shots until it empties.
Dump Head
Dump Head.png
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311.0 Flies around the room, leaving trails of Brown Creep. Initially bounces off walls for a few seconds before gaining control and chasing Isaac.
Pacer
Pacer.png
11.1 Walks aimlessly around the room.
Gusher
Gusher.png
11.0 Walks aimlessly around the room, occasionally firing a short ranged blood shot.
Level 2 Gusher
Level 2 Gusher.png
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286.0 Runs aimlessly around the room. Occasionally spits up Small Maggots.
Splasher
Splasher.png
238.0 Walks aimlessly around the room, firing Ipecac shots in random directions.
Black Globin's Body
Black Globin's Body.png
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280.0 Walks aimlessly around the room, occasionally spawning spiders.
Horf
Horf.png
12.0 Stationary enemy that fires a medium-ranged blood shot at Isaac when he gets in range of them.
Sub Horf
Sub Horf.png
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242.0 Stationary enemy that turns around with each shot. Only fires when hit.
Tainted Sub Horf
Tainted Sub Horf.png
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242.0 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Psychic Horf
Psychic Horf.png
248.0 Stationary enemy that fires a homing shot at Isaac when he gets in range of them.
Level 2 Horf
Level 2 Horf.png
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285.0 Floating enemy that spits Small Maggots at Isaac.
Fly
Fly.png
13.0 Tiny black fly with neutral AI. Does not hurt Isaac upon touch.
Attack Fly
Attack Fly.png
18.0 Red fly that follows Isaac and deals touch damage.
Dart Fly
Dart Fly.png
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256.0 Flies towards Isaac and attempts to mimic his movements. Deals contact damage.
Swarm Fly
Swarm Fly.png
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281.0 Follows Isaac in large groups and deals contact damage.
Ring Fly
Ring Fly.png
222.0 Gathers with any other Ring Flies in the room. These flies orbit around themselves while following Isaac.
Army Fly
Army Fly.png
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868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room.
Hush Fly
Hush Fly.png
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296.0 Gathers with other Hush Flies and flies towards Isaac in certain patterns. Can also orbit Hush.
Willo
Willo.png
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96.1 Forms a circle around Isaac, keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Moter
Moter.png
80.0 Follows Isaac, similar to Attack Flies. Splits into 2 Attack Flies upon death.
Eternal Fly
Eternal Fly.png
96.0 Invulnerable fly that circles Corny Poop and various monsters. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Fly Bomb
Fly Bomb.png
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254.0 Flies towards Isaac, circling around him as they do so. Upon death, turns into a tiny Bomb.
Sucker
Sucker.png
61.0 Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit
Spit.png
61.1 Flies slowly towards Isaac, firing an Ipecac shot towards Isaac upon death.
Ink
Ink.png
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61.3 Flies slowly towards Isaac. Spawns four tar shots in the ordinal directions and leaves black creep upon death.
Soul Sucker
Soul Sucker.png
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61.2 Flies slowly towards Isaac. Spawns a vortex that fires four Brimstone beams in the cardinal directions upon death.
Tainted Sucker
Tainted Sucker.png
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61.7 Flies towards Isaac. Upon death, shoots 6 large blood shots in a hexagon pattern that become 6 smaller shots upon contact with a wall or obstacle.
Bulb
Bulb.png
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61.5 Flies in erratic, right-angled movements towards Isaac if his active item has charges.
Bloodfly
Bloodfly.png
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61.6 Flies in erratic, right-angled movements towards Isaac. Fires four blood shots in the cardinal directions on death.
Pooter
Pooter.png
14.0 Slow-moving fly that occasionally fires single blood shots at Isaac. Does not deal touch damage.
Super Pooter
Super Pooter.png
14.1 An alternate version of the Pooter that fires 2 shots in a V-formation and does not deal touch damage.
Tainted Pooter
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14.2 Slowly drifts towards Isaac, shoots 4 big blood shots that become 2 smaller ones when in contact with a wall or obstacle.
Mama Fly
Mama Fly.png
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61.4 Wanders aimlessly around the room, occasionally creating Pustles.
Clotty
Clotty.png
15.0 Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Grilled Clotty
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15.3 Shoots four flame shots in the cardinal directions at a high speed.
Cloggy
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306.0 Shoots four curved brown shots in the cardinal directions alternating clockwise and counterclockwise.
Clot
Clot.png
15.1 Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I.Blob
I.Blob.png
15.2 Randomly wanders around the room, firing 8 shots in all directions.
Mulligan
Mulligan.png
16.0 Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be Flies, Attack Flies or Pooters. Can suicide to explode and launch four projectiles in the cardinal directions while still releasing flies.
Mulligoon
Mulligoon.png
16.1 Walks around the room, avoiding Isaac. Upon death, spawns a Troll Bomb and fires four shots in the ordinal directions. Can suicide to explode, spawn a Troll bomb, and launch eight projectiles in all directions.
Mulliboom
Mulliboom.png
16.2 Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive
Hive.png
22.0 Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of flies upon death, which can be Flies, Attack Flies or Pooters.
Drowned Hive
Drowned Hive.png
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22.1 Walks around the room, avoiding Isaac while spawning Drowned Chargers. Spawns a Drowned Charger upon death.
Prey
Prey.png
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817.0 Walks around the room, avoiding Isaac. Spawns 2-3 Small Leeches as means of attack.
Fartigan
Fartigan.png
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874.0 Chases Isaac, occasionally coughing up gas. On death, fires an explosive shot that can detonate gas clouds it hits.
Nest
Nest.png
205.0 Walks around the room, avoiding Isaac while spawning Spiders. Spawns a Big Spider or a Trite upon death.
Leper
Leper.png
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310.0 Walks around the room, chasing Isaac but running away if they take damage. Releases a Leper Flesh for every 15 damage taken. After being reduced to 15 health, chases Isaac continously and leaves damaging Red Creep. Spawns a Leper Flesh and a Grey-coloured Gusher upon death.
Leper Flesh
Leper Flesh.png
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310.1 Moves erratically and chases Isaac. Fires a blood shot at Isaac upon death.
Holy Mulligan
Holy Mulligan.png
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22.2 Wanders around the room, avoiding Isaac. Occasionally spawns an Angelic Baby if Isaac gets close to it.
Mullighoul
Mullighoul.png
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817.1 Walks around the room, avoiding Isaac and spawning Willos. Spawn 1-2 Willos upon death.
Tainted Mulligan
Tainted Mulligan.png
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22.3 Walks around the room, avoiding Isaac and spawning Ring Flies. Spawns a plethora of fly enemies upon death.
Bouncer
Bouncer.png
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822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Danny
Danny.png
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255.0 Chases Isaac and spits a bunch of rock shots at him when in its line of sight.
Coal Boy
Coal Boy.png
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241.4 Walks toward Isaac and fires chaotic bursts of coal at him, some of which may be Coal Spiders.
Blaster
Blaster.png
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208.0 Slowly wanders around and occasionally shoots tiny bombs at Isaac.
Maggot
Maggot.png
21.0 Aimlessly moves around the room, dealing contact damage.
Small Maggot
Small Maggot.png
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289.0 Aimlessly moves around the room, dealing contact damage.
Charger
Charger.png
23.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight.
Level 2 Charger
Level 2 Charger.png
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291.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Carrion Princess
Carrion Princess.png
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23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech.png
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240.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Drowned Charger
Drowned Charger.png
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23.1 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Charger
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23.2 Slowly moves around the room, charging at Isaac very rapidly when he gets in its line of sight, leaving a trail of slowing Black Creep.
Spitty
Spitty.png
31.0 Slowly moves around the room, occasionally firing a single blood shot forward.
Tainted Spitty
Tainted Spitty.png
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243.1 Quickly yet aimlessly moves around the room, spurting blood shots out of its back and firing a line of blood shots at Isaac. Sends a ring of blood shots outwards upon death.
Conjoined Spitty
Conjoined Spitty.png
243.0 Slowly moves around the room, occasionally firing a blood shot from both ends of its body.
Globin
Globin.png
24.0 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin
Gazing Globin.png
24.1 Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which will slide away from Isaac and can be killed. Will regenerate after a short period of time if not killed quickly.
Dank Globin
Dank Globin.png
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24.2 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a Spider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Black Globin
Black Globin.png
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278.0 Chases Isaac, dealing a full heart of contact damage and spawning Spiders whenever it takes damage. Spawns a Spider, a Black Globin's Head, and a Black Globin's Body upon death.
Cursed Globin
Cursed Globin.png
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24.3 Chases Isaac. It splits into 2 goos when destroyed, which become 2 Cursed Globins.
Cohort
Cohort.png
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857.0 Acts similarly to Monstro, and can shoot a variety of projectiles. Spawns four Globins upon death.
Gasbag
Gasbag.png
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856.0 Occasionally summons Army Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Boom Fly
Boom Fly.png
25.0 Flies around the room diagonally, dealing touch damage and exploding upon death.
Red Boom Fly
Red Boom Fly.png
25.1 Flies around the room diagonally, dealing touch damage and releasing 6 blood shots in all directions upon death.
Drowned Boom Fly
Drowned Boom Fly.png
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25.2 Flies around the room diagonally, dealing touch damage. Upon death, explodes and fires four blood shots in the cardinal directions. High chance to spawn a Drowned Charger upon death.
Dragon Fly
Dragon Fly.png
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25.3.0 Flies around the room diagonally, dealing touch damage. Upon death, they spawn 4 lines of fire in the cardinal directions.
Dragon Fly X
Dragon Fly X.png
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25.3.1 Flies around the room diagonally, dealing touch damage. Upon death, they fire 4 lines of fire in the diagonal directions.
Bone Fly
Bone Fly.png
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25.4 Flies around the room diagonally, dealing touch damage. Occasionally fires one bone at Isaac. Upon death, shoots 3 bones.
Sick Boom Fly
Sick Boom Fly.png
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25.5 Flies around the room diagonally dealing touch damage and trailing poisonous gas. Upon death they explode into a cloud of gas and release 6 green shots in all directions.
Tainted Boom Fly
Tainted Boom Fly.png
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25.6 Flies around the room diagonally, dealing touch damage. Upon death, sends explosions in a cross-shaped marker across the room.
Maw
Maw.png
26.0 Slowly floats towards Isaac, firing blood shots at him when he is in their range.
Red Maw
Red Maw.png
26.1 Floats towards Isaac and releases 4 blood shots in the cardinal directions upon death.
Psychic Maw
Psychic Maw.png
26.2 Slowly floats towards Isaac, firing homing shots at him when he is in their range. Spawns with an Eternal Fly orbiting around it.
Host
Host.png
27.0 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots in a spread and lower its head again.
Red Host
Red Host.png
27.1 Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Hard Host
Hard Host.png
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27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will release a line of rocks towards Isaac.
Mobile Host
Mobile Host.png
204.0 Acts like the Host, but follows Isaac and deals contact damage.
Flesh Mobile Host
Flesh Mobile Host.png
247.0 Acts like the Red Host, but follows Isaac and deals contact damage.
Floating Host
Floating Host.png
859.0 Bounces around diagonally, occasionally opening up to shoot a triple shot.
Hopper
Hopper.png
29.0 Slowly hops around the room, doing touch damage. Can turn into a Flaming Hopper by jumping into fire.
Flaming Hopper
Flaming Hopper.png
54.0 Quickly hops around the room, doing touch damage. Covers a larger distance than the regular Hopper.
Leaper
Leaper.png
34.0 Hops around the room, doing touch damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
Sticky Leaper
Sticky Leaper.png
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34.1 Jumps to Isaac's position, spewing several tar shots around themselves. Leaves black creep wherever they land.
Eggy
Eggy.png
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29.2 Behaves similarly to Hopper, jumping around the room and chasing Isaac, spawning white creep wherever it jumps. When it takes enough damage, it spawns a group of Swarm Spiders.
Tainted Hopper
Tainted Hopper.png
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29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Trite
Trite.png
29.1 Quickly leaps towards Isaac and deals touch damage.
Ragling
Ragling.png
246.0 Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
Rag Man's Ragling
Rag Man's Ragling.png
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246.1 Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
Blister
Blister.png
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303.0 Slowly hops towards Isaac, occasionally spawning a Dark Ball. Spawns a Sack upon death.
Boil
Boil.png
30.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut
Gut.png
30.1 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Ipecac shots in random directions when fully swollen.
Sack
Sack.png
30.2 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns Spiders when fully swollen.
Blue Boil
Blue Boil.png
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298.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Gush
Gush.png
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309.0 Stationary, harmless enemy that continually creates slowing black creep.
Pustule
Pustule.png
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309.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Small Maggots when fully swollen.
Walking Boil
Walking Boil.png
88.0 Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut
Walking Gut.png
88.1 Does not shrink or regenerate. Walks around aimlessly and fires Ipecac shots in random directions.
Walking Sack
Walking Sack.png
88.2 Does not shrink or regenerate. Walks around aimlessly and occasionally spawns Spiders.
Brain
Brain.png
32.0 Slowly crawls around the room, leaving a trail of Red Creep.
Poison Mind
Poison Mind.png
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301.0 Slowly crawls around the room diagonally, leaving a trail of Green Creep.
Pon
Pon.png
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840.0 Hops around the room aimlessly, leaving Red Creep wherever it lands, killing their corresponding Brainless Knight upon death.
Black Globin's Head
Black Globin's Head.png
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279.0 Slides towards Isaac, leaving a trail of damaging Red Creep.
Gyro
Gyro.png
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260.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight.
Grilled Gyro
Grilled Gyro.png
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261.0 Rolls around like a wheel quite quickly. Charges at Isaac when he is in line of sight.
Mr. Maw
Mr. Maw.png
35.0 Walks towards Isaac and attacks by launching its head towards him. Turns into a Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Mr. Red Maw
Mr. Red Maw.png
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35.2 Walks towards Isaac and attacks by launching its head towards him. Turns into a Red Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Swinger
Swinger.png
216.0 Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a Maw or a Globin depending on which part is killed.
Mr. Mine
Mr. Mine.png
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311.0 Can only appear in pits. Attempts to launch itself at Isaac if he comes near. Occasionally burrows and pops up in another pit, and fires six shots in all directions upon death.
Baby
Baby.png
38.0 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere.
Angelic Baby
Angelic Baby.png
38.1.0 Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
Angelic Baby (small)
Angelic Baby (small).png
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38.1.1
Wrinkly Baby
Wrinkly Baby.png
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38.3 Lunges towards Isaac at high speed and fires three blood shots in his direction once stopped.
Imp
Imp.png
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259.0 Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Baby Begotten
Baby Begotten.png
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319.0 Fires a small Collectible Brimstone icon.png Brimstone at Isaac when in range.
Vis
Vis.png
39.0 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser when Isaac gets in its line of sight.
Double Vis
Double Vis.png
39.1 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
Chubber
Chubber.png
39.2 Randomly wanders around the room. Pauses to fire a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, has limited range, and flies back to the Chubber.
Scarred Double Vis
Scarred Double Vis.png
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39.3 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Vis Versa
Vis Versa.png
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39.4 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis.png
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39.5 Randomly wanders around the room. Pauses to charge and launches a string of guts when Isaac gets in its line of sight.
Guts
Guts.png
40.0 Attaches itself to a wall or obstacle and rolls around it.
Scarred Guts
Scarred Guts.png
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40.1 Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Slog
Slog.png
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40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst.png
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298.0 Attaches itself to a wall or obstacle and rolls around it, shooting 1 blood shot when Isaac is near.
Knight
Knight.png
41.0 Moves erratically around the room and charges towards Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight
Selfless Knight.png
41.1 Moves erratically around the room and charges towards Isaac very quickly when in line of sight. Can only be damaged from behind.
Floating Knight
Floating Knight.png
254.0 Behaves like the Knight but slower, and can fly over all obstacles.
Bone Knight
Bone Knight.png
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283.0 Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Loose Knight
Loose Knight.png
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41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When killed, turns into a Brainless Knight and a Pon.
Brainless Knight
Brainless Knight.png
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41.3 Moves erratically around the room, charges toward Isaac when in line of sight.
Black Knight
Black Knight.png
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41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon bumping into an obstacle.
Whipper
Whipper.png
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274.0 Utilises a whip to target Isaac.
Snapper
Snapper.png
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275.0 Utilises a long whip to target Isaac.
Flagellant
Flagellant.png
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276.0 Quickly swipes while charging.
Dople
Dople.png
53.0 Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin
Evil Twin.png
53.1 Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Leech
Leech.png
55.0 Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech
Kamikaze Leech.png
55.1 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech
Holy Leech.png
55.2 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it, which instantly dies when the Holy Leech explodes.
Adult Leech
Adult Leech.png
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290.0 Behaves like Leeches, releases a ring of blood shots in all directions upon colliding with the wall. Occasionally burrows into the ground and reappears out of a wall or from above.
Lump
Lump.png
56.0 Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing.
Tar Boy
Tar Boy.png
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307.0 Fires a short-ranged spray of shots that leave behind slowing Black Creep. Occasionally burrows underground and reappears under any pools of black creep in the room. If Isaac stands on the Creep, the Tar Boy can fire shots straight upwards out of the Creep underneath Isaac.
MemBrain
MemBrain.png
57.0 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.
Mama Guts
Mama Guts.png
57.1 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Guts upon death.
Dinga
Dinga.png
223.0 Slowly moves around the room, occasionally hopping to spawn Dips or fire 8 Brown shots in all directions. Splits 2 Squirts upon death.
Mega Clotty
Mega Clotty.png
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282.0 Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a Clotty or a collapsed Globin. Splits into two Clotties upon death.
Dead Meat
Dead Meat.png
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57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 Cysts upon death.
Para-Bite
Para-Bite.png
58.0 Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
Scarred Para-Bite
Scarred Para-Bite.png
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58.1 Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Fred
Fred.png
59.0 Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Eye
Eye.png
60.0 Slowly turns towards Isaac and fires a Technology laser at Isaac if he stands still or is too slow.
Bloodshot Eye
Bloodshot Eye.png
60.1 Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Holy Eye
Holy Eye.png
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60.2 Rapidly summons several beams of light towards Isaac every few seconds.
Embryo
Embryo.png
77.0 Aimlessly hops around the room, dealing contact damage.
Spider
Spider.png
85.0 Erratically moves towards Isaac and deals touch damage.
Strider
Strider.png
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245.0 Erratically moves towards Isaac and deals touch damage.
Swarm Spider
Swarm Spider.png
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320.0 Erratically moves towards Isaac and deals touch damage.
Big Spider
Big Spider.png
94.0 Erratically moves towards Isaac and deals touch damage. Splits into two Spiders upon death.
Rock Spider
Rock Spider.png
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251.0 Erratically moves towards Isaac and deals touch damage, though a bit slower in comparison to Spiders.
Tinted Rock Spider
Tinted Rock Spider.png
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252.0 Erratically moves towards Isaac and deals touch damage, though a bit slower in comparison to Spiders.
Coal Spider
Coal Spider.png
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253.0 Erratically moves towards Isaac and deals touch damage, though a bit faster in comparison to Spiders.
Keeper
Keeper.png
86.0 Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Buttlicker
Buttlicker.png
89.0 Can start Attached to other Buttlickers and erratically moves around the room, similar to Larry Jr..
Butt Slicker
Butt Slicker.png
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313.0 Drags its self towards Isaac, leaving black creep. Sticks to other Butt Slickers, and creates a ring of black shots when breaking off. This ring gets bigger the more Butt Slickers attached.
Hanger
Hanger.png
90.0 Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an Eternal Fly circling around it.
Swarmer
Swarmer.png
91.0 Slowly floats around the room, spawning several Attack Flies. Spawns Pooters upon taking damage. Spawns a Boom Fly upon death.
Mask + Heart
Mask Heart.png
92.0 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Mask II + 1/2 Heart
Mask Heart II.png
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92.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Baby Long Legs
Baby Long Legs.png
206.0 Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs
Small Baby Long Legs.png
206.1 Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs
Crazy Long Legs.png
207.0 Chases Isaac, dealing touch damage. Occasionally stops to spit 8 blood shots in all directions.
Small Crazy Long Legs
Small Crazy Long Legs.png
207.1 Chases Isaac, dealing touch damage. Occasionally stops to spit 4 blood shots in the diagonal directions.
Fatty
Fatty.png
208.0 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
Flaming Fatty
Flaming Fatty.png
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208.1 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.
Blubber
Blubber.png
210.0 Walks around aimlessly and randomly spews a cluster of blood shots in all directions. Has a chance to turn into a Half Sack when killed.
Pale Fatty
Pale Fatty.png
210.1 Slowly walks towards Isaac. Occasionally farts and shoots 6 blood shots in all directions. Has a chance to turn into a Blubber upon death.
Fat Sack
Fat Sack.png
209.0 Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of Red Creep and shooting 6 blood shots in all directions where it lands. Has a chance to turn into a Blubber upon death.
Conjoined Fatty
Conjoined Fatty.png
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257.0 Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty.png
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257.1 Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Peeping Fatty
Peeping Fatty.png
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277.0 Slowly walks towards Isaac with two indestructible eyeballs that are out of their sockets but attached by the muscles. Occasionally farts and shoots 6 blood shots in all directions.
Bloaty
Bloaty.png
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314.0 Lumbers around, periodically spits green creep in front of itself or diagonally. Occasionally spits out a bunch of green shots.
Bubbles
Bubbles.png
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237.0 Walks towards Isaac and occasionally farts. Spawns a geyser of water shots upon death.
Shady
Shady.png
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888.0 Fires a black and red shot at Isaac that may spawn other shots nearby. Upon colliding with an obstacle, the shot will burst into a cloud of smaller ones. Shadies ay also jump, causing explosions in the cardinal directions.
Quakey
Quakey.png
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259.0 Attempts to jump on Isaac, shooting out 8 rock shots when it hits the ground.
Stoney
Stoney.png
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302.0 Chases Isaac and blocks tears, but does not deal contact damage. Temporarily pauses in exhaustion after a certain amount of time. Invulnerable; dies when the room is cleared.
Cross Stoney
Cross Stoney.png
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302.10 Chases Isaac and shoots 4 tears vertically and diagonally like a Cross Grimace. Dies when the room is cleared.
Only appears in Aprils Fool (challenge #32) as replacements to regular Stoneys.
Death's Head
Death's Head.png
212.0 Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Dank Death's Head
Dank Death's Head.png
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212.1 Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Flesh Death's Head
Flesh Death's Head.png
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286.0 Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Cursed Death's Head
Cursed Death's Head.png
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212.2 Invulnerable enemy that moves diagonally around the room. If Isaac enters its purple aura, he will be inflicted with the fear status effect for around two seconds. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head.png
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212.3 Invulnerable enemy that moves diagonally around the room. If Isaac enters its line of sight, it will charge a Collectible Brimstone icon.png Brimstone laser at him. Dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head.png
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887.0 Invulnerable enemy that moves across the room in large quantities. Dies when the room is cleared.
Redskull
Redskull.png
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212.4
Mom's Hand
Mom's Hand.png
213.0 Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. Entering a room containing Mom's Hand will warn the player with Mom's laugh.
Mom's Dead Hand
Mom's Dead Hand.png
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287.0 Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.
Level 2 Fly
Level 2 Fly.png
214.0 Flies toward Isaac erratically, dealing touch damage.
Full Fly
Full Fly.png
249.0 Flies toward Isaac erratically, dealing touch damage. Releases 6 bullets in all directions upon death.
Level 2 Spider
Level 2 Spider.png
215.0 Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances.
Ticking Spider
Ticking Spider.png
250.0 Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Explodes upon death.
Migraine
Migraine.png
215.0 Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Releases multiple Troll Bombs upon death.
Dip
Dip.png
217.0 Slowly dashes in random directions, dealing contact damage.
Corn
Corn.png
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217.1 Quickly dashes in random directions, dealing contact damage.
Big Corn
Big Corn.png
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217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Brownie Corn
Brownie Corn.png
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217.2 Quickly dashes in random directions, dealing contact damage.
Drip
Drip.png
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304.0 Quickly rolls around towards Isaac, dealing contact damage.
Wizoob
Wizoob.png
219.0 Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Red Ghost
Red Ghost.png
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285.0 Disappears, then reappears near Isaac and fires a brimstone laser.
Squirt
Squirt.png
220.0 Dashes towards the player and deals contact damage. Spawns 2 Dips upon death.
Dank Squirt
Dank Squirt.png
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220.1 Dashes towards the player and deals contact damage. Spawns 2 Clots upon death.
Splurt
Splurt.png
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305.0 Dashes towards the player twice and deals contact damage.
Hardy
Hardy.png
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263.0 Charges at Isaac, crashes into obstacles and fires 8 rock shots outwards.
Cod Worm
Cod Worm.png
221.0 Stationary enemy that hides in a shell and spews a burst of blood shots if shot at. Only vulnerable when it pops its head out.
Oob
Oob.png
224.0 When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw
Black Maw.png
225.0 When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Leeches. Explodes when it dies.
Skinny
Skinny.png
226.0 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself.
Rotty
Rotty.png
226.1 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself. Spawns a Bony or two Attack Flies upon death.
Crispy
Crispy.png
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226.2 Slowly walks towards Isaac, but increases in speed as they take damage. Constantly passively takes damage.
Bony
Bony.png
227.0 Wanders around the room and throws a bone at Isaac when he is in sight.
Black Bony
Black Bony.png
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277.0 Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Holy Bony
Holy Bony.png
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227.1 Wanders around the room and throws a bone surrounded by blue flame at Isaac when he is in sight.
Homunculus
Homunculus.png
228.0 Starts attached to the wall or an Dlc a† indicator.png obstacle. After a while, it detaches, shooting 6 blood shots in all directions, leaving a puddle of Red Creep and chasing Isaac. If it dies while still attached, it will still leave a puddle of Red Creep.
Begotten
Begotten.png
251.0 Starts attached to the wall or an Dlc a† indicator.png obstacle. After a while, it detaches, firing 6 blood shots in all directions, turning the room dark, becoming invisible and chasing Isaac. Briefly becomes visible upon getting hit.
Tumor
Tumor.png
229.0 Moves around the room diagonally, occasionally firing 6 blood shots in all directions. Fires more often upon getting damaged.
Psy Tumor
Psy Tumor.png
253.0 Moves around the room diagonally, occasionally firing 6 homing shots in all directions. Fires more often upon getting damaged.
Camillo Jr.
Camillo Jr..png
230.0 Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Planetoid
Planetoid.png
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229.1 Moves around the room diagonally, occasionally firing 6 orbital blood shots. Periodically releases poisonous gas.
Nerve Ending
Nerve Ending.png
231.0 Static enemy which acts as a meat shield.
Nerve Ending 2
Nerve Ending 2.png
Dlc a† indicator.png
231.1 Static enemy which whips at Isaac if he gets too close.
Bishop
Bishop.png
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805.0 Provides invincibility to any other enemy in the room.
One Tooth
One Tooth.png
234.0 Follows Isaac and periodically dashes towards him when it gets close. Deals contact damage.
Fat Bat
Fat Bat.png
Dlc a indicator.png
258.0 Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Gurgling
Gurgling.png
237.0 Charges towards Isaac when he lines up with them, leaving a trail of Red Creep and shooting 6 blood shots.
Maze Roamer
Maze Roamer.png
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331.0 Quickly walks around the room, shoots an eyeball at Isaac when he is in sight.
Goat
Goat.png
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332.0 Walks towards Isaac and occasionally charges at him.
Black Goat
Black Goat.png
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333.0 Walks towards Isaac, shoots 4-way Collectible Brimstone icon.png Brimstone beams, and occasionally charges at him.
Cultist
Cultist.png
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321.0 Wanders quickly around the room, reviving enemies that have died in the current room. Also creates an indestructible, homing Purple Ball at the start of the room.
Blood Cultist
Blood Cultist.png
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322.0 Fires a line of blood shots and creep if Isaac is on either side of it. Occasionally summons bone traps that temporarily ensnare Isaac if he walks into them.
Grub
Grub.png
239.0 Erratically moves around the room like Larry Jr. and charges at Isaac when he gets within its line of sight. Spawns Maggots, Chargers, or Spitties upon death, one for each of its segments.
Wall Creep
Wall Creep.png
240.0 Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Blind Creep
Blind Creep.png
242.0 Randomly crawls along walls and shoots three spread blood shots.
The Thing
The Thing.png
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304.0 Crawls along a wall and attempts to line up with Isaac, then spits a line of damaging Red Creep.
Soy Creep
Soy Creep.png
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240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by Collectible Soy Milk icon.png Soy Milk.
Tainted Soy Creep
Tainted Soy Creep.png
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240.3
Rage Creep
Rage Creep.png
241.0 Slowly crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
Round Worm
Round Worm.png
244.0 Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Tainted Round Worm
Tainted Round Worm.png
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244.2 Pops out of the ground in random locations alongside several tail ends and spits 1 large blood shot at Isaac. Explodes upon death.
Roundy
Roundy.png
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276.0 Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Ulcer
Ulcer.png
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289.0 Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Night Crawler
Night Crawler.png
255.0 Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
Tube Worm
Tube Worm.png
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255.1 Pops out of the ground in random locations and fires a long-range spray of arcing shots.
Tainted Tube Worm
Tainted Tube Worm.png
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244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Fire Worm
Fire Worm.png
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262.0 Pops out of the ground in random locations and fires one flame at Isaac.
Mole
Mole.png
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829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole.png
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829.1
Lil' Haunt
Lil' Haunt.png
260.0 Follows Isaac erratically and occasionally shoots a blood shot towards Isaac's destination, predicting his movements.
Polty
Polty.png
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247.0 Picks up and throws pots and rocks at Isaac.
Kineti
Kineti.png
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248.0 Uses telekinesis to pick up and throw pots and rocks at Isaac.
Dukie
Dukie.png
Dlc a indicator.png
288.0 Flies around the room diagonally, occasionally spitting out 1-2 Dart Flies.
Meatball
Meatball.png
Dlc a indicator.png
290.0 Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Mushroom
Mushroom (Enemy).png
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300.0 Stationary enemy that occasionally pops up and fires four shots in the cardinal or diagonal directions. Takes less damage while its head is down.
Ministro
Ministro.png
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305.0 Hops towards Isaac, occasionally spitting out a cluster of disorganized shots.
Fistuloid
Fistuloid.png
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308.0 Flies towards Isaac in an erratic waving motion, periodically firing a blood shot towards Isaac that also knocks itself back. Upon death, fires a worm that flies off screen.
Poot Mine
Poot Mine.png
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309.0 Farts when hit, explodes upon death.
Portal
Portal.png
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306.0 Spawns various enemies from the current floor until it either vanishes or is killed.
Lil Portal
Lil Portal.png
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227.0 Spawns fly and spider enemies until it is destroyed.
Stone Grimace
Stone Grimace.png
42.0 Stationary and invulnerable monster that occasionally fires a blood shot at Isaac. Stops firing when room is cleared.
Vomit Grimace
Vomit Grimace.png
42.1 Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Triple Grimace
Triple Grimace.png
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42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Gaping Maw
Gaping Maw.png
235.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Broken Gaping Maw
Broken Gaping Maw.png
236.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles. Alternates between active and inactive every couple of seconds. Has a stronger attraction power than a regular Gaping Maw.
Constant Stone Shooter
Constant Stone Shooter.png
202.0 Stationary and invulnerable monster that continuously fires shots in a single direction.
Cross Stone Shooter
Cross Grimace.png
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202.10 Stationary and invulnerable monster that continuously fires shots in four directions, alternating between cardinal and ordinal.
Brimstone Head
Brimstone Head.png
203.0 Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Quake Grimace
Quake Grimace.png
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804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace.png
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809.0 Stationary and invulnerable monster that keeps a single Throwable Bomb spawned.
Stone Eye
Stone Eye.png
201.0 Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Mockulus
Mockulus.png
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864.0 Rapidly bounces around the room diagonally while Isaac is shooting.
Morningstar
Morningstar.png
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863.0 Floats towards Isaac to deal contact damage, only when Isaac is moving. Gets faster the longer Isaac has been moving for. Stops in place when Isaac stops moving.
Poky
Poky.png
44.0 Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Slide
Slide.png
44.1 Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Wall Hugger
Wall Hugger.png
218.0 Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Grudge
Grudge.png
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312.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Pitfall
Pitfall.png
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291.0 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall.png
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291.1 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Suction Pitfall
Suction Pitfall.png
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291.2 Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Death Scythe
Death Scythe.png
66.10 Stays stationary for a few seconds, then homes in on Isaac.
Corn Mine
Corn Mine.png
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295.0 Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Dark Ball
Dark Ball.png
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404.1 Floats towards Isaac, doing contact damage.
Purple Ball
Purple Ball.png
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409.1 Floats towards Isaac, doing contact damage.
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner).png
Dlc a indicator.png
293.0 Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key).png
Dlc a indicator.png
293.1 Spins on itself and opens a golden door around the room if not destroyed.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb).png
Dlc a indicator.png
293.2 Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart).png
Dlc a indicator.png
293.3 Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Mother's Shadow
Mother's Shadow.png
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867.1
Needle
Needle.png
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316.0 Lunges towards Isaac, dealing contact damage.
Pasty
Pasty.png
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317.0 Behaves like a Needle, lunging towards Isaac to deal contact damage. The only difference is that when it emerges off the ground, it shoots 4 blood shots in the ordinal directions.
Fissure
Fissure.png
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815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.

Champions

Some monsters can spawn as a Champion which deviates in coloration and size. The champion's coloration/size denotes which peculiar behaviors and traits it will exhibit. Champions will generally drop a pickup (coinciding with the color of the champion) when killed on normal difficulty. However, in hard mode, the drop rate is reduced to 33%, while in Greed Mode, champions won't drop pickups at all.

Most champions have a visual 15% size increase, inflict full heart damage regardless of chapter, and have double the health of a normal monster. Champions are generally regarded as more dangerous than common monsters.

Dlc na† indicator.png Champions always deal contact damage, regardless of what monster they are (e.g. a common Mulligan will not deal contact damage, but champion versions will).

The identifying scheme for champion qualities is as follows:

ID Appearance Effect Drop Rarity Notes
0 Champion Red.png
Vivid Red
×2.5 amount of HP. Heart Common
1 Champion Yellow.png
Dark Yellow
Increased movement speed.
Dlc r indicator.png These champions cannot spawn during Chapter 1.
Little battery Common
2 Champion Green.png
Strong Lime Green
Leaves green creep as it walks. Pill Common
3 Champion Orange.png
Vivid Orange
Attacks cause you to drop coins (like Greed or a Hanger).

The number of coins dropped range from 1-3, which take away 2-4 coins in total respectively. No coins are dropped if you don't have any.

Coin Around 2x rarer than common champions.
4 Champion Dark Blue.png
Vivid Blue
Decreased speed. 3 Blue Flies Around 2x rarer than common champions.
5 Champion Dark Green.png
Dark Cyan
Explodes when killed. Bomb Common
6 Champion Solid White.png
White
Invincible until all other enemies are killed. Eternal Heart Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
7 Champion Gray.png
Dark Gray
2/3 health, decreased speed. Key Common
8 Champion Transparent White.png
Transparent White
Tears become spectral tears, and it can move past environmental obstacles (such as pits) that it otherwise couldn't when forced. Locked Chest Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
9 Champion Black.png
Black
Fades in and out of visibility, like a Null. Red Chest Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
10 Champion Pink.png
Pure Magenta
Periodically shoots short-ranged blood shots, similar to Gushers. Nothing Common
11 Champion Purple.png
Mostly Pure Violet
Pulls Isaac and his shots towards itself, like a Gaping Maw. Random trinket Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
12 Champion Dark Red.png
Dark Red
Collapses into a flesh pile upon death and regenerates if not finished off (like a Globin). Double Heart Around 2x rarer than common champions.
13 Champion Light Blue.png
Very Light Blue
Releases blood shots in 8 directions when killed. 1/2 heart Common
Dlc a indicator.png Afterbirth
14 Champion Camouflage.png
Camouflage
The enemy blends into the background and briefly becomes visible when damaged. Rune Around 4x rarer than common champions.
15 Champion Pulsing Green.gif
Pulsing Strong Lime Green
Splits into two copies of itself upon death. 2 normal versions of itself Around 4x rarer than common champions.
16 Champion Pulsing Gray.gif
Pulsing Dark Gray
Repels Isaac's shots when it pulses. Nothing Around 4x rarer than common champions.
17 Champion Light White.png
Light White
Has 1-2 Eternal Flies circling it. Spawns another fly upon death. Attack Fly Around 4x rarer than common champions.
18 Gaper.png
Small
Decreased health, increased speed and pitch of sound effects. 50% smaller both visually and collision-wise, making them more difficult to hit. One Makes You Small pill at 1/5th of difficulty based drop rate. Around 4x rarer than common champions. Using the pill dropped will change all other pills matching its color into One Makes You Small pills.
19 Gaper.png
Large
Increased health, slightly decreased speed and decreased pitch of sound effects. Visually 50% larger, though collision remains the same. Deals two full hearts of damage. One Makes You Larger pill at 1/5th of difficulty based drop rate; can change other pills in the current rotation. Around 4x rarer than common champions. Using the pill dropped will change all other pills matching its color into One Makes You Larger pills.
Dlc a† indicator.png Afterbirth+
20 Champion Pulsing Red.gif
Pulsing Vivid Red
All other enemies in the room regenerate health at the rate of 20 HP per second while this enemy is alive. Heart Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
21 Champion Pulsating.gif
Pulsating
Spawns an Attack Fly on hit. After each hit, there is a delay until the next hit results in another Attack Fly. A single Pulsating enemy can have up to 5 Attack Flies at once. 4-6 Blue Flies Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
22 Champion Crown.png
Crown
Increased health. All enemies in the room that are not champions will turn yellow while the crowned enemy is alive. The affected enemies will drop batteries like yellow champions upon dying, but otherwise have no extra health, speed or damage 2-3 random pickups Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
23 Champion Skull.png
Skull
Produces a Collectible The Necronomicon icon.png The Necronomicon effect upon death. Deals two full hearts of damage. Collectible The Necronomicon icon.png The Necronomicon effect Around 10x rarer than common champions. Doesn't appear until entering BothIndicator.png Stage The Depths icon.png The Depths and its alts, or Both Greed Modes Indicator.png Stage Sheol icon.png Sheol in Greed Mode.
Dlc r indicator.png Repentance
24
Brown
Trails poop behind it as it walks. Nothing Unknown
25
Rainbow
Combines the effects of champion types 0, 2, 5, 10, 11, 13 and 17. A coin, a bomb, a key, a heart, a pill, a card and a trinket. Unknown

The chances for Champion monsters to appear are noted in the table below:

Modifiers Normal mode Hard mode Stage The Void icon.png The Void
Base chance 5% 20% 75%
Collectible Champion Belt icon.png Champion Belt 20% 35% 75%
Trinket Purple Heart icon.png Purple Heart 10% 40% 100%
Trinket Purple Heart icon.png Purple Heart + Dlc a indicator.png Collectible Mom's Box icon.png Mom's Box 20% 80% 100%
Collectible Champion Belt icon.png Champion Belt + Trinket Purple Heart icon.png Purple Heart 40% 70% 100%
Collectible Champion Belt icon.png Champion Belt + Trinket Purple Heart icon.png Purple Heart + Dlc a indicator.png Collectible Mom's Box icon.png Mom's Box 80% 100% 100%
  • Collectible Champion Belt icon.png Champion Belt adds 15% to the base champion chance. This has no effect in Stage The Void icon.png The Void.
  • Trinket Purple Heart icon.png Purple Heart doubles the champion chance, and stacks with Champion's Belt.
    • Dlc a indicator.png Collectible Mom's Box icon.png Mom's Box changes Purple Heart to quadruple the chances instead of doubling.

Monster Replacements

Some monsters have a chance to be replaced with other monsters when they spawn, Dlc a† indicator.png but only at room entry. Dlc a indicator.png Some replacements only occur on certain floors.

(Disclaimer: Chances are approximate!)

Base Monster Replacement Chance Notes
Rebirth
Mulligan.png Mulligoon.png 10%
Mulligan.png Mulliboom.png 1%
Mulligoon.png
Hopper.png Trite.png 6%
Stone Grimace.png Vomit Grimace.png 6%
Dople.png Evil Twin.png 5%
Eye.png Bloodshot Eye.png 5%
Leech.png Kamikaze Leech.png 5%
Leech.png Holy Leech.png 1%
Kamikaze Leech.png
Maw.png Red Maw.png 10%
Maw.png Psychic Maw.png 1%
Red Maw.png
Host.png Red Host.png 10%
Vis.png Double Vis.png 6%
Vis.png Chubber.png 1%
Double Vis.png
Boom Fly.png Red Boom Fly.png 10%
Pooter.png Super Pooter.png 10%
Knight.png Selfless Knight.png 5%
Clotty.png I.Blob.png 1%
Clot.png
MemBrain.png Mama Guts.png 6%
Globin.png Gazing Globin.png 10%
Baby.png Angelic Baby.png 6%
Boil.png Gut.png 6%
Boil.png Sack.png 1%
Gut.png
Walking Boil.png Walking Gut.png 6%
Walking Boil.png Walking Sack.png 1%
Walking Gut.png
Sucker.png Spit.png 6%
Poky.png Slide.png 6%
Dlc a indicator.png Afterbirth
Frowning Gaper.png Flaming Gaper.png 60% Exclusive to Stage Burning Basement icon.png Burning Basement
Gaper.png
Fatty.png Flaming Fatty.png 60% Exclusive to Stage Burning Basement icon.png Burning Basement
Only a single Burning Basement room contains a Pale Fatty, making it a very unusual replacement to witness.
Pale Fatty.png
Hopper.png Flaming Hopper.png 60% Exclusive to Stage Burning Basement icon.png Burning Basement
Trite.png
Hive.png Drowned Hive.png 50% Exclusive to Stage Flooded Caves icon.png Flooded Caves
Maggot.png Drowned Charger.png 50% Exclusive to Stage Flooded Caves icon.png Flooded Caves
Charger.png
Spitty.png
Boom Fly.png Drowned Boom Fly.png 50% Exclusive to Stage Flooded Caves icon.png Flooded Caves
Red Boom Fly.png
Squirt.png Dank Squirt.png 50% Exclusive to Stage Dank Depths icon.png Dank Depths
Death's Head.png Dank Death's Head.png 50% Exclusive to Stage Dank Depths icon.png Dank Depths
Globin.png Dank Globin.png 50% Exclusive to Stage Dank Depths icon.png Dank Depths
Gazing Globin.png
Guts.png Scarred Guts.png 50% Exclusive to Stage Scarred Womb icon.png Scarred Womb
Para-Bite.png Scarred Para-Bite.png 50% Exclusive to Stage Scarred Womb icon.png Scarred Womb
Vis.png Scarred Double Vis.png 50% Exclusive to Stage Scarred Womb icon.png Scarred Womb
Double Vis.png
Dlc a† indicator.png Afterbirth+
Keeper.png Blister.png 10%
Ticking Spider.png 20%
Host.png Mushroom (Enemy).png 20%
Red Host.png
Hopper.png Ministro.png 20%
Trite.png
Nerve Ending.png Nerve Ending 2.png 20%
Brain.png Poison Mind.png 20%
Pale Fatty.png Stoney.png 10%
Wall Creep.png The Thing.png 20%
Blind Creep.png
Rage Creep.png
Mr Maw.png Mr. Red Maw.png 20%
Skinny.png
Crispy.png
40% Exclusive to Stage Burning Basement icon.png Burning Basement
Rottys do not appear in any Burning Basement room layouts, but can still be replaced regardless.
Rotty.png
Dank Charger.png Drowned Charger.png 50% Exclusive to Stage Flooded Caves icon.png Flooded Caves
Dank Chargers do not appear in any Flooded Caves room layouts, but can still be replaced regardless.
Stoney.png Cross Stoney.png 20% Exclusive to Aprils Fool challenge

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Character Isaac appearance.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Collectible Isaac's Tears icon.png Item pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red Heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations Trinket The Left Hand icon.png Trinkets
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