Binding of Isaac: Rebirth Wiki
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Monsters refers to the many antagonistic creatures and entities the player will encounter throughout the game.

Most monsters (with few exceptions) will damage Isaac by either touching him or shooting him with projectiles. Less frequently, monsters will spawn additional, lesser monsters, spread creep, or attempt to affect the player's movement. Some monsters become tougher the further along they're encountered. Along with the more common variety of monsters, champion versions can be found lurking about; These monsters are often like their common counterparts, but have a color tint or size change, more health, and drop basic pickups on death. There are also champion versions of most bosses.

There are 196 naturally spawning monsters in total. 40 of them were added in Afterbirth and 21 were added in Afterbirth † (13 were added in Booster Packs). Almost all of these naturally spawning entities are featured in the Added in Afterbirth † Bestiary.

Monster List

Entity ID Description
Frowning Gaper
Frowning Gaper
10.0 Walks towards Isaac, dealing contact damage. They start out with their eyes closed, but when they gain line of sight with Isaac, their eyes open and they permanently move faster. Usually turns into a Pacer Pacer or a Gusher Gusher upon death
Gaper
Gaper
10.1 Walks towards Isaac, dealing contact damage. Usually turns into a Pacer Pacer or a Gusher Gusher upon death.
Flaming Gaper
Flaming Gaper
Added in Afterbirth
10.2 Walks towards Isaac, dealing contact damage. Usually turns into a Pacer Pacer or Gusher Gusher upon death.
Rotten Gaper
Rotten Gaper
Added in Repentance
10.3 Walks toward Isaac, dealing contact damage. Its behavior varies slightly depending on its facial expression.
Gurgle
Gurgle
87.0 Walks towards Isaac, dealing contact damage and periodically firing Ipecac Ipecac shots at him; they are immune to this explosion, but other enemies are not. Can turn into a Splasher Splasher upon death.
Crackle
Crackle
Added in Repentance
87.1 Walks toward Isaac, dealing contact damage and spitting fireballs that create lines of fire in the cardinal directions on impact.
Nulls
Nulls
252.0 Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes, though its speed doesn't change. Fades into and out of visibility.
Cyclopia
Cyclopia
Added in Afterbirth
284.0 Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Blue Gaper
Blue Gaper
Added in Afterbirth
297.0 Walks towards Isaac, dealing contact damage.
Greed Gaper
Greed Gaper
Added in Afterbirth
299.0 Walks towards Isaac, dealing contact damage.
Wraith
Wraith
Added in Repentance
807.0 Walks toward Isaac, dealing contact damage. They are invisible and can only be seen through the reflection they cast in the water, or the ripples they make as they walk.
Deep Gaper
Deep Gaper
Added in Repentance
811.0 Emerges from the floor once all previous enemies have been killed, then proceeds to chase Isaac. Deals contact damage.
Blurb
Blurb
Added in Repentance
813.0 Walks slowly towards Isaac, dealing contact damage. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly. Can turn into a Pacer Pacer or Gusher Gusher upon death.
Level 2 Gaper
Level 2 Gaper
Added in Repentance
850.0 Walks towards Isaac, dealing a full Heart of contact damage. Splits into a Level 2 Horf Level 2 Horf and Level 2 Gusher Level 2 Gusher upon death.
Level 2 Horf
Level 2 Horf
Added in Repentance
850.1 Slowly floats toward Isaac, spitting Small Maggots at him.
Level 2 Gusher
Level 2 Gusher
Added in Repentance
850.2 Runs aimlessly around the room, spitting up Small Maggots.
Twitchy
Twitchy
Added in Repentance
851.0 Alternates between walking towards and rapidly leaping at Isaac, dealing contact damage. Can leap to Isaac's current position, or where Isaac is heading, and can also leap away to dodge incoming fire.
Dead Isaac
Dead Isaac
Added in Repentance
912.20 Summoned by Mother Mother at the bottom of the arena, they walk upward (ignoring Isaac completely), and deal contact damage. Releases a burst of blood shots upon being killed by Mother, while she launches their corpses towards Isaac.
Faceless
Faceless
Added in Repentance
827.0 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots more frequently after taking damage.
Tainted Faceless
Tainted Faceless
Added in Repentance
827.1 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots very frequently after taking damage.
Exorcist
Exorcist
Added in Repentance
832.0 Summons The Heretic before transforming into Fanatics.
Fanatic
Fanatic
Added in Repentance
832.1 Transformed into from Exorcists. Chases Isaac and occasionally fires two purple, rotating shots.
Dump
Dump
Added in Repentance
876.0 Slides toward Isaac, leaving a trail of slippery brown creep. After taking enough damage, its head slides off and quickly bounces around the room and its body spews out brown shots until it empties.
Dump Head
Dump Head
Added in Repentance
876.1 Quickly slides toward Isaac, leaving a trail of slippery brown creep. Can spawn on its own or be created by a Dump after it takes enough damage.
Gusher
Gusher
11.0 Walks aimlessly around the room, occasionally firing a short-ranged blood shot.
Pacer
Pacer
11.1 Walks aimlessly around the room.
Splasher
Splasher
238.0 Walks aimlessly around the room, firing Ipecac shots in random directions.
Black Globin's Body
Black Globin's Body
Added in Afterbirth
280.0 Walks aimlessly around the room, occasionally spawning spiders.
Horf
Horf
12.0 Stationary enemy that fires a medium-ranged blood shot at Isaac when he gets in range of them.
Psychic Horf
Psychic Horf
248.0 Stationary enemy that fires a homing shot at Isaac when he gets in range of them.
Sub Horf
Sub Horf
Added in Repentance
812.0 Stationary enemy that spins and fires shots while being moved around or knocked back.
Tainted Sub Horf
Tainted Sub Horf
Added in Repentance
812.1 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Necro
Necro
Added in Repentance
828.0 Stationary enemy that summons unlimited-ranged bones to attack Isaac.
Fly
Fly
13.0 Hovers in place. Does not deal contact damage and is harmless but can turn into Pooters if they stay around Poop.
Attack Fly
Attack Fly
18.0 Red fly that follows Isaac and deals contact damage.
Moter
Moter
80.0 Follows Isaac, similar to Attack Flies. Deals contact damage. Splits into 2 Attack Flies upon death.
Eternal Fly
Eternal Fly
96.0 Invulnerable fly that circles Corny Poop and various monsters. Deals contact damage. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Ring Fly
Ring Fly
222.0 Gathers with any other Ring Flies in the room. These flies orbit around themselves while following Isaac. Deals contact damage.
Dart Fly
Dart Fly
Added in Afterbirth
256.0 Flies towards Isaac and attempts to predict his movements. Deals contact damage.
Swarm
Swarm
Added in Afterbirth
281.0 Follows Isaac in large, tightly-clustered groups and deals contact damage.
Hush Fly
Hush Fly
Added in Afterbirth
296.0 Gathers with other Hush Flies to form certain patterns. If spawned by Hush, can chase Isaac or orbit Hush. Deals contact damage.
Willo
Willo
Added in Repentance
808.0 Flies in a circle around Isaac (in formation with other Willos if available), keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Army Fly
Army Fly
Added in Repentance
868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room. Deals contact damage.
Ultra Famine Fly
Ultra Famine Fly
Added in Repentance
951.11 Charges at Isaac at a delay. Deals contact damage. Spawned by Ultra Famine.
Ultra Pestilence Fly
Ultra Pestilence Fly
Added in Repentance
951.21 Flies in swarms around Ultra Pestilence, blocking shots and dealing contact damage.
Fly Bomb
Fly Bomb
Added in Repentance
819.0 Flies toward Isaac, circling around him as it does. Turn into a tiny bomb upon death.
Eternal Fly Bomb
Eternal Fly Bomb
Added in Repentance
819.1 Orbits Boom Flies spawned by The Horny Boys. Once its Boom Fly has been killed, turns into a tiny Bomb.
Sucker
Sucker
61.0 Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit
Spit
61.1 Flies slowly towards Isaac, firing an Ipecac Ipecac shot towards Isaac upon death.
Ink
Ink
Added in Repentance
61.2 Flies slowly towards Isaac. Fires four shots in the ordinal directions and leaves a puddle of slowing Black Creep upon death.
Soul Sucker
Soul Sucker
Added in Afterbirth †
61.3 Flies slowly towards Isaac. Spawns a vortex that fires four Brimstone Brimstone beams in the cardinal directions upon death.
Mama Fly
Mama Fly
Added in Repentance
61.4 Flies more-or-less away from Isaac, occasionally plopping on the ground to plant a Added in Repentance Pustule Pustule. Upon death, they spawn a group of Added in Repentance Small Maggot Small Maggots.
Bulb
Bulb
Added in Repentance
61.5 Flies in erratic, angled movements toward Isaac if his active item has charges; on contact, they drain up to 2 charges, but never deal contact damage. If he has no active item, or no charges, they wander around the room aimlessly.
Bloodfly
Bloodfly
Added in Repentance
61.6 Spawned only after a Pustule Pustule bursts. Flies in erratic, angled movements toward Isaac. Fires four blood shots in the cardinal directions upon death.
Tainted Sucker
Tainted Sucker
Added in Repentance
61.7 Flies slowly towards Isaac. Upon death, fires a radial burst of six blood shots that each also fires a radial burst of six blood shots.
Pooter
Pooter
14.0 Slowly drifts toward Isaac, occasionally firing a single blood shot at him. Does not deal contact damage.
Super Pooter
Super Pooter
14.1 Slowly drifts toward Isaac, occasionally firing two blood shots in a V-formation at him. Does not deal contact damage.
Tainted Pooter
Tainted Pooter
Added in Repentance
14.2 Slowly drifts toward Isaac, occasionally firing four blood shots at him that split into two smaller ones when they hit a wall or obstacle.
Clotty
Clotty
15.0 Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Clot
Clot
15.1 Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I.Blob
I.Blob
15.2 Randomly wanders around the room, firing 8 shots in all directions.
Grilled Clotty
Grilled Clotty
Added in Repentance
15.3 Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.
Cloggy
Cloggy
Added in Repentance
872.0 Randomly wanders around the room, firing four curved brown shots in the cardinal directions. These shots alternate between rotating clockwise and counterclockwise with each shot.
Mulligan
Mulligan
16.0 Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be Flies, Attack Flies, and/or Pooters. Can self-detonate and launch four projectiles in the cardinal directions while still releasing flies.
Mulligoon
Mulligoon
16.1 Walks around the room, avoiding Isaac. Upon death, spawns a Troll Bomb and fires four shots in the ordinal directions. Can self-detonate, spawn a Troll bomb, and launch eight projectiles in all directions.
Mulliboom
Mulliboom
16.2 Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive
Hive
22.0 Wanders around the room, avoiding Isaac and spawning Attack Flies if he gets close. Spawns a large number of flies on death, which can be Flies, Attack Flies, and/or Pooters.
Drowned Hive
Drowned Hive
Added in Afterbirth
22.1 Wanders around the room, avoiding Isaac and spawning Drowned Chargers if he gets close. Spawns 0-2 Drowned Chargers upon death.
Holy Mulligan
Holy Mulligan
Added in Repentance
22.2 Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.
Tainted Mulligan
Tainted Mulligan
Added in Repentance
22.3 Wanders around the room, avoiding Isaac and spawning 6 Ring Flies if he gets close. Spawns a plethora of fly enemies upon death.
Nest
Nest
205.0 Wanders around the room, avoiding Isaac and spawning Spiders if he gets close. Spawns a Big Spider or Trite upon death.
Leper
Leper
Added in Afterbirth †
310.0 Alternating between walking towards and running away from Isaac. Releases a Leper Flesh each time it takes enough damage. At low health, constantly chases Isaac and leaves behind damaging red creep. Spawns a Leper Flesh and Gusher upon death.
Leper Flesh
Leper Flesh
Added in Afterbirth †
310.1 Floats slowly toward Isaac and fires a predictive projectile at him upon death.
Prey
Prey
Added in Repentance
817.0 Wanders around the room, avoiding Isaac and spawning Small Leeches if he gets close. Spawns 3 Small Leeches upon death.
Mullighoul
Mullighoul
Added in Repentance
817.1 Wanders around the room, avoiding Isaac and spawning Willos if he gets close. Spawns 1-2 Willos upon death.
Bouncer
Bouncer
Added in Repentance
822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Gas Dwarf
Gas Dwarf
Added in Repentance
874.0 Chases Isaac, periodically coughing up gas clouds. On death, fires an explosive shot that can detonate gas clouds it hits.
Danny
Danny
Added in Repentance
820.0 Walks toward Isaac and spits chaotic bursts of rocks at him, some of which may be Rock Spiders.
Coal Boy
Coal Boy
Added in Repentance
820.1 Walks toward Isaac and spits hot coals at him, some of which may be Coal Spiders.
Blaster
Blaster
Added in Repentance
821.0 Slowly wanders around and occasionally shoots Fly Bombs at Isaac.
Maggot
Maggot
21.0 Aimlessly moves around the room, dealing contact damage.
Charger
Charger
23.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight.
My Shadow
My Shadow
Added in Afterbirth
23.0.1 Charges at enemies when in its line of sight, dealing contact damage. Will always spawn friendly via My Shadow.
Drowned Charger
Drowned Charger
Added in Afterbirth
23.1 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Charger
Dank Charger
Added in Afterbirth †
23.2 Slowly moves around the room, launching itself at Isaac if he gets in its line of sight. Bounces off of walls and leaves a trail of slowing Black Creep while charging.
Carrion Princess
Carrion Princess
Added in Repentance
23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech
Added in Repentance
810.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Small Maggot
Small Maggot
Added in Repentance
853.0 Slowly crawls toward Isaac, dealing contact damage.
Level 2 Charger
Level 2 Charger
Added in Repentance
855.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Elleech
Elleech
Added in Repentance
855.1 Slowly moves around the room. After Isaac gets in its line of sight, continuously charges at him in the closest cardinal direction.
Blood Puppy
Blood Puppy
Added in Repentance
802.0 Quickly moves around the room, attacking and charging at other monsters and Isaac when they get in its line of sight.
Spitty
Spitty
31.0 Slowly moves around the room, occasionally firing a single blood shot forward.
Tainted Spitty
Tainted Spitty
Added in Repentance
31.1 Slowly moves around the room, firing chaotic bursts of blood shots in all directions and occasionally spitting a line of blood shots in the direction it's facing. Fires two rotating rings of blood shots upon death.
Conjoined Spitty
Conjoined Spitty
243.0 Slowly moves around the room, occasionally firing a blood shot from both ends of its body.
Globin
Globin
24.0 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin
Gazing Globin
24.1 Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which will slide away from Isaac and can be killed. Will regenerate after a short period of time if not killed quickly.
Dank Globin
Dank Globin
Added in Afterbirth
24.2 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a Spider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Cursed Globin
Cursed Globin
Added in Repentance
24.3 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into 1-2 piles of goo, each of which can be killed and regenerate after a short period of time if not killed quickly. These goo piles have less health the more times the Cursed Globin splits.
Black Globin
Black Globin
Added in Afterbirth
278.0 Chases Isaac, dealing a full heart of contact damage and launching Spiders towards Isaac whenever it takes damage. Spawns a Spider, a Black Globin's Head, and a Black Globin's Body upon death.
Clickety Clack
Clickety Clack
Added in Repentance
889.0 Walks towards Isaac and turn into a pile of bones when killed. Regenerates a few seconds after killed. Will only despawn if all Clickety Clacks in the room are killed.
Gasbag
Gasbag
Added in Repentance
856.0 Occasionally summons Army Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Cohort
Cohort
Added in Repentance
857.0 Acts similarly to Monstro, hopping towards Isaac and can either spit a large projectile towards Isaac that bursts into 8 smaller projectiles or cough up a burst of arcing projectiles and a pile of Globin goo. Spawns 4 piles of Globin goo upon death.
Boom Fly
Boom Fly
25.0 Flies across the room in straight diagonal lines, dealing contact damage. Explodes upon death.
Red Boom Fly
Red Boom Fly
25.1 Flies across the room in straight diagonal lines, dealing contact damage. Creates a ring of 6 blood shots upon death.
Drowned Boom Fly
Drowned Boom Fly
Added in Afterbirth
25.2 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, explodes and fires four blood shots in the cardinal directions. Also has a chance to spawn a Added in Afterbirth Drowned Charger Drowned Charger upon death.
Dragon Fly
Dragon Fly
Added in Repentance
25.3.0 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, creates four lines of fire in the cardinal directions; the fire nearly spans the length of an entire normal-sized room.
Dragon Fly X
Dragon Fly X
Added in Repentance
25.3.1 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, creates four lines of fire in the ordinal directions; the fire nearly spans the length of an entire normal-sized room.
Bone Fly
Bone Fly
Added in Repentance
25.4 Flies across the room in straight diagonal lines, dealing contact damage. Fires bones at Isaac if he lines up with it in the cardinal directions. Fires a radial burst of 3 bones upon death.
Sick Boom Fly
Sick Boom Fly
Added in Repentance
25.5 Flies across the room in straight diagonal lines, dealing contact damage and trailing poisonous gas. Upon death, explodes into a gas cloud and fires a ring of 6 green shots.
Tainted Boom Fly
Tainted Boom Fly
Added in Repentance
25.6 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, it glows brightly, warning that it is about to explode; this explosion sends 4 line of further explosions in the cardinal directions, which span the length of the room.
Maw
Maw
26.0 Slowly floats towards Isaac, firing a blood shot at him when he is in their range.
Red Maw
Red Maw
26.1 Floats quickly towards Isaac and releases 4 blood shots in the cardinal directions upon death.
Psychic Maw
Psychic Maw
26.2 Slowly floats towards Isaac, firing homing shots at him when he is in their range. Spawns with an Eternal Fly orbiting around it.
Host
Host
27.0 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots in a spread and lower its head again.
Red Host
Red Host
27.1 Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Hard Host
Hard Host
Added in Repentance
27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Shortly after raising its head, it slams its head down and fires a rock wave towards Isaac.
Mobile Host
Mobile Host
204.0 Acts like the Host, but follows Isaac and deals contact damage.
Flesh Mobile Host
Flesh Mobile Host
247.0 Acts like the Red Host, but follows Isaac and deals contact damage.
Floast
Floast
Added in Repentance
859.0 Floats diagonally around the room and is normally invulnerable. When Isaac gets close, reveals a fleshy stem that can be damaged and fires 3 blood shots in an angle at him before hiding its stem again.
Mushroom
Mushroom
Added in Afterbirth †
300.0 Stationary enemy that occasionally pops up and fires four shots in the cardinal or diagonal directions. Takes less damage while its head is down.
Hopper
Hopper
29.0 Slowly hops around the room, doing contact damage. Can turn into a Flaming Hopper by jumping into fire.
Eggy
Eggy
Added in Repentance
29.2 Hops aimlessly around the room, spawning slowing white creep wherever it hops. Spawns a group of Swarm Spiders upon death.
Tainted Hopper
Tainted Hopper
Added in Repentance
29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Leaper
Leaper
34.0 Hops around the room, doing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
Sticky Leaper
Sticky Leaper
Added in Repentance
34.1 Hops around the room, dealing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while creating a chaotic burst of tar shots in all directions and a puddle of slowing black creep.
Flaming Hopper
Flaming Hopper
54.0 Quickly hops around the room, doing contact damage. Covers a larger distance than the regular Hopper.
Trite
Trite
29.1 Quickly leaps towards Isaac and deals contact damage.
Ragling
Ragling
246.0 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Rag Man's Ragling
Rag Man's Ragling
Added in Afterbirth
246.1 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Blister
Blister
Added in Afterbirth †
303.0 Slowly hops towards Isaac, occasionally spawning a Dark Ball. Spawns a Sack upon death.
Boil
Boil
30.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut
Gut
30.1 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Ipecac Ipecac shots in random directions when fully swollen.
Sack
Sack
30.2 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns Spiders when fully swollen.
Blue Boil
Blue Boil
Added in Afterbirth
298.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Gush
Gush
Added in Afterbirth †
309.0 Stationary, harmless enemy that continually creates slowing black creep.
Pustule
Pustule
Added in Repentance
861.0 Slowly increases in size over time, spawning Small Maggots and damaging red creep depending on its size upon death. If it grows to full size, it transforms into a Bloodfly.
Walking Boil
Walking Boil
88.0 Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut
Walking Gut
88.1 Does not shrink or regenerate. Walks around aimlessly and fires Ipecac Ipecac shots in random directions.
Walking Sack
Walking Sack
88.2 Does not shrink or regenerate. Walks around aimlessly and occasionally spawns Spiders.
Brain
Brain
32.0 Slowly crawls around the room, leaving a trail of Red Creep.
Black Globin's Head
Black Globin's Head
Added in Afterbirth
279.0 Slides towards Isaac, leaving a trail of damaging Red Creep.
Festering Guts
Festering Guts
Added in Repentance
279.20 Spawned by Gutted Fatties, Festering Guts randomly slide around the room and occasionally spawn a Charger.
Poison Mind
Poison Mind
Added in Afterbirth †
301.0 Slowly Removed in Repentancecrawls/Added in Repentancefloats around the room diagonally, leaving a trail of damaging green creep. Added in Repentance Explodes upon death.
Pon
Pon
Added in Repentance
840.0 Hops around the room, leaving damaging red creep wherever it lands. Upon death, its associated Brainless Knight dies with it.
Gyro
Gyro
Added in Repentance
824.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles as it does.
Grilled Gyro
Grilled Gyro
Added in Repentance
824.1 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles and creating fires behind itself as it does.
Mr. Maw
Mr. Maw
35.0 Walks towards Isaac and attacks by launching its head towards him. Turns into a Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Mr. Red Maw
Mr. Red Maw
Added in Afterbirth †
35.2 Walks towards Isaac and attacks by launching its head towards him. Turns into a Red Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Swinger
Swinger
216.0 Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a Maw or a Globin depending on which part is killed.
Mr. Mine
Mr. Mine
Added in Afterbirth †
311.0 Can only appear in pits. Attempts to launch itself at Isaac if he comes near. Occasionally burrows and pops up in another pit, and fires six shots in all directions upon death.
Baby
Baby
38.0 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere.
Angelic Baby
Angelic Baby
38.1.0 Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
Angelic Baby (small)
Angelic Baby (small)
Added in Repentance
38.1.1 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere. Can only be spawned by Holy Mulligans.
Wrinkly Baby
Wrinkly Baby
Added in Repentance
38.3 Dashes towards Isaac at high speed and fires three blood shots in his direction once stopped.
Imp
Imp
Added in Afterbirth
259.0 Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Unborn
Unborn
Added in Repentance
860.0 Floats quickly towards Isaac, and occasionally teleports to another position near him.
Baby Begotten
Baby Begotten
Added in Repentance
883.0 Floats toward Isaac, avoiding his shots. After getting close, fires a short Brimstone Brimstone laser in the closest cardinal direction and propels itself away from him.
Vis
Vis
39.0 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser when Isaac gets in its line of sight.
Double Vis
Double Vis
39.1 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
Chubber
Chubber
39.2 Randomly wanders around the room. Pauses to fire a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, has limited range, and flies back to the Chubber.
Scarred Double Vis
Scarred Double Vis
Added in Afterbirth
39.3 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Vis Versa
Vis Versa
Added in Repentance
836.0 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis
Added in Repentance
865.0 Randomly wanders around the room. Launches a string of guts when Isaac gets close to it, which it uses to pull Isaac toward itself.
Guts
Guts
40.0 Attaches itself to a wall or obstacle and rolls around it.
Scarred Guts
Scarred Guts
Added in Afterbirth
40.1 Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Slog
Slog
Added in Repentance
40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst
Added in Repentance
862.0 Attaches itself to a wall or obstacle and rolls around it, regularly firing blood shots at Isaac.
Knight
Knight
41.0 Moves erratically around the room and charges towards Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight
Selfless Knight
41.1 Moves erratically around the room and charges towards Isaac very quickly when in line of sight. Can only be damaged from behind.
Loose Knight
Loose Knight
Added in Repentance
41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When its health is depleted, it turns into a Brainless Knight and a Pon.
Brainless Knight
Brainless Knight
Added in Repentance
41.3 Alternates between running around the room along the cardinal directions and aimlessly walking in circles. Charges at Isaac when in line of sight. Dies when its corresponding Pon dies.
Black Knight
Black Knight
Added in Repentance
41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon charging into an obstacle. Shots that hit it from the front are deflected back at Isaac.
Floating Knight
Floating Knight
254.0 Behaves like the Knight but slower, and can fly over all obstacles.
Bone Knight
Bone Knight
Added in Afterbirth
283.0 Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Whipper
Whipper
Added in Repentance
834.0 Runs around the room, sprinting at Isaac when he gets in its line of sight and lashing at him when it gets close.
Snapper
Snapper
Added in Repentance
834.1 Runs around the room, sprinting at Isaac when he gets in its line of sight and throwing out its whip when he gets in range.
Flagellant
Flagellant
Added in Repentance
834.2 Runs around the room. When Isaac gets in its line of sight, continuously chases him and lashes its whip, occasionally deflecting Isaac’s shots.
Dople
Dople
53.0 Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin
Evil Twin
53.1 Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Leech
Leech
55.0 Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech
Kamikaze Leech
55.1 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech
Holy Leech
55.2 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it, which instantly dies when the Holy Leech explodes.
Adult Leech
Adult Leech
Added in Repentance
854.0 Wanders around the room, quickly charging at Isaac when he lines up diagonally with him and releasing a ring of blood shots upon colliding with a wall. Occasionally burrows into the ground and reappears out of a wall or from above Isaac.
Lump
Lump
56.0 Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing.
Tar Boy
Tar Boy
Added in Afterbirth †
307.0 Fires a short-ranged spray of shots that leave behind slowing Black Creep. Occasionally burrows underground and reappears under any pools of black creep in the room. If Isaac stands on the Creep, the Tar Boy can Removed in Repentance fire shots straight upwards out of the Creep underneath Isaac/Added in Repentance send out a tentacle underneath Isaac.
MemBrain
MemBrain
57.0 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.
Mama Guts
Mama Guts
57.1 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Guts upon death.
Dead Meat
Dead Meat
Added in Repentance
57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 Cysts upon death.
Dinga
Dinga
223.0 Slowly moves around the room, occasionally hopping to spawn Dips or fire 8 Brown shots in all directions. Splits 2 Squirts upon death.
Mega Clotty
Mega Clotty
Added in Afterbirth
282.0 Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a Clotty or a collapsed Globin. Splits into two Clotties upon death.
Para-Bite
Para-Bite
58.0 Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
Scarred Para-Bite
Scarred Para-Bite
Added in Afterbirth
58.1 Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Fred
Fred
59.0 Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Eye
Eye
60.0 Slowly turns towards Isaac and fires a Technology laser at Isaac if he stands still or is too slow.
Bloodshot Eye
Bloodshot Eye
60.1 Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Holy Eye
Holy Eye
Added in Repentance
60.2 Rapidly summons several beams of light around Isaac every few seconds.
Embryo
Embryo
77.0 Aimlessly hops around the room, dealing contact damage.
Spider
Spider
85.0 Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage.
Big Spider
Big Spider
94.0 Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage. Spawns two Spiders upon death.
Strider
Strider
Added in Repentance
814.0 Erratically swims around the room. If it sees Isaac, it chases him, trying to deal contact damage.
Rock Spider
Rock Spider
Added in Repentance
818.0 Slowly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Spider upon death. Turns into a Coal Spider if it touches fire.
Tinted Rock Spider
Tinted Rock Spider
Added in Repentance
818.1 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Soul Heart upon death. Can only spawn by breaking tinted rocks on Mines or Ashpit.
Coal Spider
Coal Spider
Added in Repentance
818.2 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a hot coal upon death that blocks shots and deals contact damage, but can be destroyed.
Swarm Spider
Swarm Spider
Added in Repentance
884.0 Very erratically hops toward Isaac in large groups, dealing contact damage.
Keeper
Keeper
86.0 Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Buttlicker
Buttlicker
89.0 Can start Attached to other Buttlickers and erratically moves around the room, similar to Larry Jr..
Butt Slicker
Butt Slicker
Added in Repentance
878.0 Moves erratically around the room unless attached to another Butt Slicker. Grouped Butt Slickers drag themselves towards Isaac, and when an individual is killed they leave black creep, and shoot out black projectiles. The amount of projectiles released and the size of the pool of Black Creep is determined by the amount of Butt Slickers attached.
Hanger
Hanger
90.0 Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an Eternal Fly circling around it.
Swarmer
Swarmer
91.0 Slowly floats around the room, spawning several Attack Flies. Spawns Pooters upon taking damage. Spawns a Boom Fly upon death.
Mask + Heart
Mask + Heart
92.0 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Mask II + 1/2 Heart
Mask II + 1/2 Heart
Added in Repentance
92.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Baby Long Legs
Baby Long Legs
206.0 Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs
Small Baby Long Legs
206.1 Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs
Crazy Long Legs
207.0 Chases Isaac, dealing touch damage. Occasionally stops to spit 8 blood shots in all directions.
Small Crazy Long Legs
Small Crazy Long Legs
207.1 Chases Isaac, dealing touch damage. Occasionally stops to spit 4 blood shots in the diagonal directions.
Fatty
Fatty
208.0 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
Pale Fatty
Pale Fatty
208.1 Slowly walks towards Isaac. Occasionally farts and shoots 6 blood shots in all directions. Has a chance to turn into a Blubber upon death.
Flaming Fatty
Flaming Fatty
Added in Afterbirth
208.2 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away Added in Repentance and spawns a damaging flame. Has a chance to leave behind a damaging flame upon death.
Fat Sack
Fat Sack
209.0 Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of Red Creep and shooting 6 blood shots in all directions where it lands. Has a chance to turn into a Blubber upon death.
Blubber
Blubber
210.0 Walks around aimlessly and randomly spews a cluster of blood shots in all directions. Has a chance to turn into a Half Sack when killed.
Half Sack
Half Sack
211.0 Wanders around aimlessly and leaves a trail of Red Creep.
Conjoined Fatty
Conjoined Fatty
Added in Afterbirth
257.0 Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty
Added in Afterbirth
257.1 Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Stoney
Stoney
Added in Afterbirth †
302.0 Chases Isaac and blocks tears, but does not deal contact damage. Temporarily pauses in exhaustion after a certain amount of time. Invulnerable; dies when the room is cleared.
Cross Stoney
Cross Stoney
Added in Afterbirth †
302.10 Chases Isaac and shoots 4 tears vertically and diagonally like a Cross Grimace. Dies when the room is cleared.
Only appears in Aprils Fool (challenge #32) as replacements to regular Stoneys.
Bubbles
Bubbles
Added in Repentance
806.0 Slowly walks towards Isaac, firing back shots upon taking damage. Occasionally farts, which pushes Isaac and adjacent enemies away and creates a chaotic burst of shots. Creates a geyser of water shots upon death.
Quakey
Quakey
Added in Repentance
823.0 Walks slowly toward Isaac, occasionally attempting to jump on Isaac, shooting out 8 rock shots when it hits the ground and causing rocks to fall from the ceiling.
Big Bony
Big Bony
Added in Repentance
830.0 Walks slowly toward Isaac, and will occasionally fire a bone that bounces around the room for a few moments. The bone can be broken if shot enough.
Gutted Fatty
Gutted Fatty
Added in Repentance
831.0 Slowly lumbers around the room, occasionally spawning Festering Guts. Its eyes dislocate as it takes damage, which are invincible and follow the Gutted Fatty but chase Isaac if he gets close to them. Creates a geyser of blood projectiles upon death.
Gutted Fatty Eye
Gutted Fatty Eye
Added in Repentance
831.10 Invulnerable enemy spawned by Gutted Fatties. Hovers around their correlating Gutted Fatty unless Isaac draws near, after which it will chase Isaac, blocking tears and dealing contact damage.
Peeping Fatty
Peeping Fatty
Added in Repentance
835.0 Has two indestructible Peeping Fatty Eyes that are out of their sockets but attached by muscles. Wanders around the room randomly, or toward Isaac if its eyes see him. Occasionally farts and fires a radial burst of 6 blood shots.
Peeping Fatty Eye
Peeping Fatty Eye
Added in Repentance
835.10 Invulnerable enemy attached to a Peeping Fatty. Follows Isaac when in line of sight, blocking tears and dealing contact damage.
Bloaty
Bloaty
Added in Repentance
879.0 Lumbers around, occasionally spitting green shots and a line of damaging green creep in a random direction.
Vis Fatty
Vis Fatty
Added in Repentance
886.0 Spawns with a Fetal Demon attached to it and slowly walks towards Isaac. Will occasionally fart, briefly pushing the demon away and spawning creep around itself and the demon. If the demon is killed first, the Fatty will shoot out Brimstone Brimstone in the diagonal direction closest to Isaac. It will then fly around the room diagonally, bumping off of walls and tall blocks all while continuously firing Brimstone Brimstone behind it.
Fetal Demon
Fetal Demon
Added in Repentance
886.1 Usually encountered tethered to Vis Fatties. When tethered it makes short lunges towards Isaac if he gets close. If the Vis Fatty is killed or when encountered alone it will chase Isaac similarly to Gemini's Suture.
Shady
Shady
Added in Repentance
888.0 Walks slowly toward Isaac, occasionally firing a shot that creates shots perpendicular to itself while traveling and splits into a ring of shots upon hitting a wall or obstacle. Also occasionally jumps, creating lines of explosions in the cardinal directions. One of the few enemies that utilize Damage Scaling.
Death's Head
Death's Head
212.0 Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Dank Death's Head
Dank Death's Head
Added in Afterbirth
212.1 Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Cursed Death's Head
Cursed Death's Head
Added in Repentance
212.2 Invulnerable enemy that moves diagonally around the room, dealing contact damage. If Isaac enters its purple aura, he will be inflicted with fear and be temporarily unable to shoot. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head
Added in Repentance
212.3 Invulnerable enemy that moves diagonally around the room, pausing to fire a Brimstone Brimstone laser when Isaac lines up with it in the cardinal directions. Dies when the room is cleared.
Redskull
Redskull
Added in Repentance
212.4 Moves diagonally around the room, creating a ring of fire around itself if Isaac gets close to it. Can be killed, but also dies when the room is cleared.
Flesh Death's Head
Flesh Death's Head
Added in Afterbirth
286.0 Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head
Added in Repentance
887.0 Invulnerable enemy that moves across the room in a waving motion in large quantities. Dies when the room is cleared.
Ultra Death Head
Ultra Death Head
Added in Repentance
951.42 Invulnerable enemy spawned by Ultra Death that moves across the room in a waving motion in large quantities as a part of one of his attacks. Dies upon the completion of the attack.
Mom's Hand
Mom's Hand
213.0 Falls from the ceiling. If it lands on Isaac, it deals damage and teleports him back to the spawn room of the floor. Entering a room containing Mom's Hand will warn Isaac with Mom's laugh.
Mom's Dead Hand
Mom's Dead Hand
Added in Afterbirth
287.0 Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn Isaac with Mom's laugh.
Level 2 Fly
Level 2 Fly
214.0 Flies toward Isaac erratically, dealing contact damage.
Full Fly
Full Fly
249.0 Flies toward Isaac erratically, dealing contact damage. Releases 6 bullets in all directions upon death.
Level 2 Willo
Level 2 Willo
Added in Repentance
838.0 Orbits enemies and shoots tears at Isaac. If the enemy it is orbiting dies, it will orbit another enemy. However, if all enemies are dead, it will chase Isaac, while still occasionally shooting at Isaac.
Level 2 Spider
Level 2 Spider
215.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances.
Ticking Spider
Ticking Spider
250.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Explodes upon death.
Migraine
Migraine
Added in Repentance
869.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Releases multiple Troll Bombs upon death.
Dip
Dip
217.0 Slowly dashes in random directions, dealing contact damage.
Corn
Corn
Added in Afterbirth
217.1 Quickly dashes in random directions, dealing contact damage.
Brownie Corn
Brownie Corn
Added in Afterbirth
217.2 Quickly dashes in random directions, dealing contact damage.
Big Corn
Big Corn
Added in Repentance
217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Drip
Drip
Added in Repentance
870.0 Quickly rolls around in diagonal directions, dealing contact damage.
Wizoob
Wizoob
219.0 Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Red Ghost
Red Ghost
Added in Afterbirth
285.0 Disappears, then reappears near Isaac and fires a brimstone laser.
Squirt
Squirt
220.0 Dashes towards Isaac and deals contact damage. Spawns 2 Dips upon death.
Dank Squirt
Dank Squirt
Added in Afterbirth
220.1 Dashes towards Isaac and deals contact damage, creating slowing black creep. Spawns 2 Clots upon death.
Hardy
Hardy
Added in Repentance
826.0 Dashes toward Isaac and deals contact damage creating rock projectiles when it hits a wall/obstacle. It spawns more rock projectiles the more times it crashes into obstacles, dying after doing so a third time.
Splurt
Splurt
Added in Repentance
871.0 Dashes towards Isaac twice and deals contact damage. Spawns 2 Drips upon death.
Cod Worm
Cod Worm
221.0 Stationary enemy that hides in a shell and spews a burst of blood shots if shot at. Only vulnerable when it pops its head out.
Oob
Oob
224.0 When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw
Black Maw
225.0 When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Leeches. Explodes when it dies.
Skinny
Skinny
226.0 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself.
Rotty
Rotty
226.1 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself. Spawns a Bony or two Attack Flies upon death.
Crispy
Crispy
Added in Afterbirth †
226.2 Slowly walks towards Isaac, but increases in speed as they take damage. Constantly passively takes damage.
Bony
Bony
227.0 Wanders around the room and throws a bone at Isaac when he is in sight.
Holy Bony
Holy Bony
Added in Repentance
227.1 Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Black Bony
Black Bony
Added in Afterbirth
277.0 Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Revenant
Revenant
Added in Repentance
841.0 Slowly wanders around the room, stopping to fire a large line of fire at the player.
Quad Revenant
Quad Revenant
Added in Repentance
841.1 Wanders around the room slowly, stopping to fire lines of flames in the cardinal or ordinal directions, rotating in an attempt to hit Isaac.
Maze Roamer
Maze Roamer
Added in Repentance
890.0 Wanders around the room and shoots an eyeball at Isaac when he is in sight. Has a clone of itself on the other side of the room that mimics its movement and shots. If one dies, the other starts actively pursuing Isaac.
Homunculus
Homunculus
228.0 Starts attached to the wall or an Added in Afterbirth † obstacle. After a while, it detaches, shooting 6 blood shots in all directions, leaving a puddle of Red Creep and chasing Isaac. If it dies while still attached, it will still leave a puddle of Red Creep.
Begotten
Begotten
251.0 Starts attached to the wall or an Added in Afterbirth † obstacle. After a while, it detaches, firing 6 blood shots in all directions, turning the room dark, becoming invisible and chasing Isaac. Briefly becomes visible upon getting hit.
Tumor
Tumor
229.0 Moves around the room diagonally, occasionally firing 6 blood shots in all directions. Fires more often upon getting damaged.
Planetoid
Planetoid
Added in Repentance
229.1 Moves around the room diagonally, occasionally firing blood shots that orbit itself. Fires more shots and has a chance to send its ring of shots outward upon taking damage.
Camillo Jr.
Camillo Jr.
230.0 Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Psy Tumor
Psy Tumor
253.0 Moves around the room diagonally, occasionally firing 6 homing shots in all directions. Fires more often upon getting damaged.
Poofer
Poofer
Added in Repentance
892.0 Slowly floats toward Isaac, swells up and fire 6 blood shots in all direction upon taking damage. Explodes upon death, healing nearby enemies and leaving a big puddle of red creep.
Nerve Ending
Nerve Ending
231.0 Static enemy which acts as a meat shield.
Nerve Ending 2
Nerve Ending 2
Added in Afterbirth †
231.1 Static enemy which whips at Isaac if he gets too close.
Bishop
Bishop
Added in Repentance
805.0 Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
One Tooth
One Tooth
234.0 Follows Isaac and periodically dashes towards him when it gets close. Deals contact damage.
Fat Bat
Fat Bat
Added in Afterbirth
258.0 Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Gurgling
Gurgling
237.0 Charges towards Isaac when he lines up with them, leaving a trail of Red Creep and shooting 6 blood shots.
Goat
Goat
Added in Repentance
891.0 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines up on either side of it.
Black Goat
Black Goat
Added in Repentance
891.1 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines upon either side of it. Can also fire thin 15►Brimstone Brimstone lasers in the cardinal directions, along with all other Black Goats in the room.
Cultist
Cultist
Added in Repentance
885.0 Creates an indestructible, homing Purple Ball at the start of the room and follows it around, occasionally leaving it to revive enemies that have died in the current room.
Blood Cultist
Blood Cultist
Added in Repentance
885.1 Wanders around the room and fires a line of blood shots and creep if Isaac is on either side of it. Can summons bone traps that temporarily ensnare Isaac if he walks into them.
Grub
Grub
239.0 Erratically moves around the room like Larry Jr. and charges at Isaac when he gets within its line of sight. Spawns Maggots, Chargers, or Spitties upon death, one for each of its segments.
Wall Creep
Wall Creep
240.0 Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Soy Creep
Soy Creep
Added in Repentance
240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by Soy Milk Soy Milk.
Tainted Soy Creep
Tainted Soy Creep
Added in Repentance
240.3 Slowly crawls along walls to try to line up with Isaac and shoots a 4 diagonal streams of Soy Milk Soy Milk shots.
Rage Creep
Rage Creep
241.0 Slowly crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
Blind Creep
Blind Creep
242.0 Randomly crawls along walls and shoots three spread blood shots.
The Thing
The Thing
Added in Afterbirth †
304.0 Crawls along a wall and attempts to line up with Isaac, then spits a line of damaging Red Creep.
Round Worm
Round Worm
244.0 Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Tube Worm
Tube Worm
Added in Afterbirth †
244.1 Pops out of the ground in random locations and fires a long-range spray of arcing shots where Isaac will be.
Tainted Round Worm
Tainted Round Worm
Added in Repentance
244.2 Pops out of the ground in random locations alongside several tail ends. The head fires a large blood shot that splits into a radial burst of 8 blood shots, while the tail ends shoot normal blood shots.
Tainted Tube Worm
Tainted Tube Worm
Added in Repentance
244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Night Crawler
Night Crawler
255.0 Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
Roundy
Roundy
Added in Afterbirth
276.0 Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Ulcer
Ulcer
Added in Afterbirth
289.0 Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Fire Worm
Fire Worm
Added in Repentance
825.0 Pops out of the ground in random locations and fires one flame at Isaac.
Mole
Mole
Added in Repentance
829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole
Added in Repentance
829.1 Dig towards Isaac and release a ring of rock waves. Fires 3 blood shots at Isaac 4 times.
Lil' Haunt
Lil' Haunt
260.0 Floats toward Isaac and occasionally fires a blood shot at him, predicting his movements.
Polty
Polty
Added in Repentance
816.0 Picks up and throws rocks and props at Isaac.
Kineti
Kineti
Added in Repentance
816.1 Uses telekinesis to pick up and throw rocks and obstacles at Isaac.
Dust
Dust
Added in Repentance
882.0 Follows Isaac, and is only visible when close to Isaac. Will begin to speed up when they are visible. Teleports away after taking enough damage.
Dukie
Dukie
Added in Afterbirth
288.0 Flies around the room diagonally, occasionally spitting out 1-2 Dart Flies.
Meatball
Meatball
Added in Afterbirth
290.0 Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Ministro
Ministro
Added in Afterbirth †
305.0 Hops towards Isaac, occasionally spitting out a cluster of disorganized shots.
Fistuloid
Fistuloid
Added in Afterbirth †
308.0 Flies towards Isaac in an erratic waving motion, periodically firing a blood shot towards Isaac that also knocks itself back. Upon death, fires a worm that flies off screen.
Fly Trap
Fly Trap
Added in Repentance
873.0 Floats towards Isaac, with 3 Attack Flies circling around it. Coughs up additional Attack Flies and releases gas to launch the Attack Flies outwards.
Poot Mine
Poot Mine
Added in Repentance
875.0 Creates a gas cloud and propels itself away from Isaac when it gets hit. Explodes on death, detonating all the gas clouds it created.
Bombgagger
Bombgagger
Added in Repentance
844.0 Spits up a Giga Bomb and runs away from it.
Flesh Maiden
Flesh Maiden
Added in Repentance
880.0 Vaguely flies towards Isaac in curved swooping motions.
Morningstar
Morningstar
Added in Repentance
863.0 Floats toward Isaac to deal contact damage while Isaac is moving, gaining speed the longer Isaac continues moving. Stops moving when Isaac stops moving.
Needle
Needle
Added in Repentance
881.0 Pops out of the ground and lunges towards Isaac, dealing contact damage.
Pasty
Pasty
Added in Repentance
881.1 Pops out of the ground and lunges toward Isaac, dealing contact damage and firing four shots in the ordinal directions.
Fissure
Fissure
Added in Repentance
815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.
Portal
Portal
Added in Afterbirth †
306.0 Spawns various enemies from the current floor until it either vanishes or is killed.
Lil Portal
Lil Portal
Added in Repentance
306.1 Spawns fly and spider enemies until it is destroyed.
Henry
Henry
Added in Repentance
837.0 Flushes itself away shortly after Isaac enters the room.
Stone Grimace
Stone Grimace
42.0 Stationary and invulnerable monster that occasionally fires a blood shot at Isaac. Stops firing when room is cleared.
Vomit Grimace
Vomit Grimace
42.1 Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Triple Grimace
Triple Grimace
Added in Repentance
42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Stone Eye
Stone Eye
201.0 Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Constant Stone Shooter
Constant Stone Shooter
202.0 Stationary and invulnerable monster that continuously fires shots in a single direction.
Cross Stone Shooter
Cross Stone Shooter
Added in Afterbirth †
202.10 Stationary and invulnerable monster that continuously fires shots in four directions, alternating between cardinal and ordinal.
Brimstone Head
Brimstone Head
203.0 Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Gaping Maw
Gaping Maw
235.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Broken Gaping Maw
Broken Gaping Maw
236.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles. Alternates between active and inactive every couple of seconds. Has a stronger attraction power than a regular Gaping Maw.
Quake Grimace
Quake Grimace
Added in Repentance
804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace
Added in Repentance
809.0 Stationary and invulnerable monster that keeps a single Throwable Bomb spawned.
Peep Eye
Peep Eye
68.1 Invulnerable enemy that floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. Spawned by Peep as apart of his fight.
Bloat Eye
Bloat Eye
68.11 Invulnerable enemy that floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. Spawned by The Bloat as apart of his fight.
Mockulus
Mockulus
Added in Repentance
864.0 Invulnerable enemy that rapidly floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. They can only move while Isaac is shooting.
Poky
Poky
44.0 Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Slide
Slide
44.1 Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Wall Hugger
Wall Hugger
218.0 Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Grudge
Grudge
Added in Repentance
877.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Ball and Chain
Ball and Chain
Added in Repentance
893.0 Spike balls that rotate at the end of a chain attached to an obstacle. If the obstacle is destroyed, the ball will fly free around the room for a while.
Spikeball
Spikeball
Added in Repentance
852.0 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Singe's Ball
Singe's Ball
Added in Repentance
915.1 Spawned exclusively as apart Singe's boss fight and used in his attacks. They can be pushed around and launched with explosions.
Pitfall
Pitfall
Added in Afterbirth
291.0 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Suction Pitfall
Suction Pitfall
Added in Afterbirth
291.1 Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall
Added in Afterbirth
291.2 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Death Scythe
Death Scythe
66.10 Stays stationary for a few seconds, then homes in on Isaac.
Ultra Death Scythe
Ultra Death Scythe
Added in Repentance
951.41 Stays stationary for a moment, then travels in straight lines towards Ultra Death.
Corn Mine
Corn Mine
Added in Afterbirth
295.0 Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Siren Minion
Siren Minion
Added in Repentance
3.220 Spawned in automatically charmed by The Siren. Orbits the boss and fires projectiles towards Isaac.
Siren Helper
Siren Helper
Added in Repentance
966.0 Spawned in by The Siren and takes the form and control of all of her charmed familiars.
Dark Ball
Dark Ball
Added in Afterbirth
404.1 Floats towards Isaac, doing contact damage.
Purple Ball
Purple Ball
Added in Afterbirth †
409.1 Floats towards Isaac, doing contact damage.
Visage Plasma
Visage Plasma
Added in Repentance
903.20 Floats in diagonal directions, doing contact damage. Spawned by The Visage and used in its phase 3 attacks.
Ultra Pestilence Fly Ball
Ultra Pestilence Fly Ball
Added in Repentance
951.23 Floats towards Isaac, doing contact damage and spawning Ultra Pestilence Flies upon taking damage.
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner)
Added in Afterbirth
293.0 Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key)
Added in Afterbirth
293.1 Spins on itself and opens a golden door around the room if not destroyed, spawning hordes of Greed Gapers.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb)
Added in Afterbirth
293.2 Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart)
Added in Afterbirth
293.3 Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Dummy
Dummy
Added in Repentance
964.0 Only encounterable through Debug Console, it is immobile, harmless, and used to track Isaac's damage.

Champions

Some monsters can spawn as a Champion which deviates in coloration and size. The champion's coloration/size denotes which peculiar behaviors and traits it will exhibit. Champions will generally drop a pickup (coinciding with the color of the champion) when killed on normal difficulty. However, in hard mode, the drop rate is reduced to 33%, while in Greed Mode, champions won't drop pickups at all.

Most champions have a visual 15% size increase, inflict full heart damage regardless of chapter, and have double the health of a normal monster. Champions are generally regarded as more dangerous than common monsters.

Removed in Afterbirth † Champions always deal contact damage, regardless of what monster they are (e.g. a common Mulligan will not deal contact damage, but champion versions will).

The identifying scheme for champion qualities is as follows:

ID Appearance Effect Drop Rarity Notes
0 Champion Red.png
Red
×2.6 amount of HP. Red Heart Common
1 Champion Yellow.png
Yellow
Increased movement speed.

Added in Repentance ×1.5 amount of HP.

Battery Common Added in Repentance Doesn't appear until entering Normal and hard modes onlyCaves Caves and its alts, or Greed and greedier modes onlyDepths Depths and its alts in Greed Mode.
2 Champion Green.png
Green
Leaves green creep as it walks. Pill Common
3 Champion Orange.png
Orange
Attacks cause you to drop pennies (like Greed or a Hanger).

The number of pennies dropped range from 1-3, which take away 2-4 pennies in total respectively. No pennies are dropped if you don't have any.

1-3 Coins

Removed in Repentance The coins will appear stacked on each other and can be picked up all at once.

Around 2x rarer than common champions.
4 Champion Dark Blue.png
Dark Blue
Decreased speed. 3 Blue Flies Around 2x rarer than common champions.
5 Champion Dark Green.png
Dark Cyan
Explodes when killed. Bomb Common
6 Champion Solid White.png
White
Invincible until all other enemies are killed.

If there is more than one invincible champion in the room, they ignore themselves in order to prevent a softlock.

Eternal Heart Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
7 Champion Gray.png
Gray
2/3 health, decreased speed. Key Common
8 Champion Transparent White.png
Translucent
Tears become spectral tears, and it can move past environmental obstacles (such as pits) that it otherwise couldn't when forced. Locked Chest

Added in Repentance Small chance to drop a Mega Chest instead.

Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
9 Champion Black.png
Black
Fades in and out of visibility, like a Null. Red Chest Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
10 Champion Pink.png
Magenta
Periodically shoots short-ranged blood shots, similar to Gushers. Nothing Common
11 Champion Purple.png
Violet
Pulls Isaac and his shots towards itself, like a Gaping Maw. Random trinket Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
12 Champion Dark Red.png
Dark Red
Collapses into a flesh pile upon death and regenerates if not finished off (like a Globin). Double Heart Around 2x rarer than common champions.
13 Champion Light Blue.png
Light Blue
Releases blood shots in 8 directions when killed. 1/2 heart Common
Added in Afterbirth Afterbirth
14 Champion Camouflage.png
Camouflage
The enemy blends into the background and briefly becomes visible when damaged. Rune Around 4x rarer than common champions.
15 Champion Pulsing Green.gif
Pulsing Green
Splits into two copies of itself upon death. 2 normal versions of itself Around 4x rarer than common champions.
16 Champion Pulsing Gray.gif
Pulsing Gray
Repels Isaac's shots when it pulses. Nothing Around 4x rarer than common champions.
17 Champion Light White.png
Light White
Has 1-2 Eternal Flies circling it. Spawns another fly upon death. Attack Fly Around 4x rarer than common champions.
18 Gaper.png
Small
2/3 health, increased speed and pitch of sound effects. 50% smaller both visually and collision-wise, making them more difficult to hit. One Makes You Small pill at 1/5th of difficulty based drop rate. Around 4x rarer than common champions. Using the pill dropped will change all other pills matching its color into One Makes You Small pills.
19 Gaper.png
Large
3x health, slightly decreased speed and decreased pitch of sound effects. Visually 50% larger, though collision remains the same. Deals two full hearts of damage. One Makes You Larger pill at 1/5th of difficulty based drop rate; can change other pills in the current rotation. Around 4x rarer than common champions. Using the pill dropped will change all other pills matching its color into One Makes You Larger pills.
Added in Afterbirth † Afterbirth+
20 Champion Pulsing Red.gif
Pulsing Red
All other enemies in the room regenerate health at the rate of 20 HP per second while this enemy is alive.

Other healing champions in the room cannot be healed.

Added in Repentance Bishops cannot be healed by this champion.

Red Heart Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
21 Champion Pulsating.gif
Pulsating
Spawns an Attack Fly on hit. After each hit, there is a delay until the next hit results in another Attack Fly. A single Pulsating enemy can have up to 5 Attack Flies at once. 4-6 Blue Flies Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
22 Champion Crown.png
Crown
6x health. All enemies in the room that are not champions will turn yellow while the crowned enemy is alive. The affected enemies will drop batteries like yellow champions upon dying, but otherwise have no extra health, speed or damage 2-3 random pickups Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
23 Champion Skull.png
Skull
Produces a The Necronomicon The Necronomicon effect upon death. Deals two full hearts of damage. The Necronomicon The Necronomicon effect Around 10x rarer than common champions. Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
Added in Repentance Repentance
24 Champion Brown.png
Brown
Trails poop behind it as it walks.

The poop cannot drop any pickups.

Nothing Unknown Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.
25 Champion Rainbow.gif
Rainbow
Combines the effects of multiple champion types.
  • Large: 3x health.
  • Dark Yellow: increased movement speed.
  • Strong Lime Green: leaves green damaging creep on the ground.
  • Light White: has a circling eternal fly.
  • Pure Magenta: fires an occasional blood shot in the direction it's facing.
  • Mostly Pure Violet: pulls Isaac and his shots towards it.
  • Dark Cyan: explode on death.
  • Very Light Blue: releases blood shots in 8 directions on death.
A coin, a bomb, a key, a heart, a pill, a card and a trinket. Unknown Doesn't appear until entering Normal and hard modes onlyDepths Depths and its alts, or Greed and greedier modes onlySheol Sheol in Greed Mode.

The chances for Champion monsters to appear are noted in the table below:

Modifiers Normal mode Hard mode The Void The Void
Base chance 5% 20% 75%
Champion Belt Champion Belt 20% 35% 75%
Purple Heart Purple Heart 10% 40% 100%
Purple Heart Purple Heart + Added in AfterbirthMom's Box Mom's Box

Added in RepentanceGolden Purple Heart Purple Heart
20% 80% 100%
Added in Repentance Golden Purple Heart Purple Heart + Added in AfterbirthMom's Box Mom's Box 30% 100% 100%
Champion Belt Champion Belt + Purple Heart Purple Heart 40% 70% 100%
Champion Belt Champion Belt + Purple Heart Purple Heart + Added in AfterbirthMom's Box Mom's Box

Added in RepentanceChampion Belt Champion Belt + Golden Purple Heart Purple Heart
80% 100% 100%
Added in Repentance Champion Belt Champion Belt + Golden Purple Heart Purple Heart + Added in AfterbirthMom's Box Mom's Box 100%
  • Champion Belt Champion Belt adds 15% to the base champion chance. This has no effect in The Void The Void.
  • Purple Heart Purple Heart doubles the champion chance, and stacks with Champion's Belt.
    • Added in AfterbirthMom's Box Mom's Box changes Purple Heart to quadruple the chances instead of doubling.

Champion Enemies

The following enemies are able to spawn as Champions.

The following enemies cannot spawn as Champions under any circumstances.


Notes

  • Added in Repentance Pulsing vivid red champions seem to be much more common.
  • Added in Afterbirth Camouflage champions will drop a random card if runes/soul stones haven't been unlocked.

Monster Replacements

Some monsters have a chance to be replaced with other monsters when they spawn, Added in Afterbirth † but only at room entry. Added in Afterbirth Some replacements only occur on certain floors.

(Disclaimer: Chances are approximate!)

Rebirth

Base Monster Replacement Chance
Mulligan.png Mulligoon.png 10%
Mulligan.png Mulliboom.png 1%
Mulligoon.png
Hopper.png Trite.png 6%
Stone Grimace.png Vomit Grimace.png 6%
Dople.png Evil Twin.png Removed in Repentance 5%
Eye.png Bloodshot Eye.png 5%
Leech.png Kamikaze Leech.png 5%
Leech.png Holy Leech.png 1%
Kamikaze Leech.png
Maw.png Red Maw.png 10%
Maw.png Psychic Maw.png 1%
Red Maw.png
Host.png Red Host.png 10%
Vis.png Double Vis.png 6% (Added in RepentanceUtero Utero only)
Vis.png Chubber.png 1%
Double Vis.png
Boom Fly.png Red Boom Fly.png 10% (Added in Repentance Not in Chapter 1)
Pooter.png Super Pooter.png 10%
Knight.png Selfless Knight.png 5%
Clotty.png I.Blob.png 1%
Clot.png
MemBrain.png Mama Guts.png 6%
Globin.png Gazing Globin.png 10%
Baby.png Angelic Baby.png 6%
Boil.png Gut.png 6%
Boil.png Sack.png 1%
Gut.png
Walking Boil.png Walking Gut.png 6%
Walking Boil.png Walking Sack.png 1%
Walking Gut.png
Sucker.png Spit.png 6%
Poky.png Slide.png 6%

Added in Afterbirth Afterbirth

Base Monster Replacement Chance Notes
Frowning Gaper.png Flaming Gaper.png 60% Exclusive to Burning Basement Burning Basement
Gaper.png
Fatty.png Flaming Fatty.png 60% Exclusive to Burning Basement Burning Basement
Only a single Burning Basement room contains a Pale Fatty, making it a very unusual replacement to witness.
Pale Fatty.png
Hopper.png Flaming Hopper.png 60% Exclusive to Burning Basement Burning Basement
Trite.png
Hive.png Drowned Hive.png 50% Exclusive to Flooded Caves Flooded Caves
Maggot.png Drowned Charger.png 50% Exclusive to Flooded Caves Flooded Caves
Charger.png
Spitty.png
Boom Fly.png Drowned Boom Fly.png 50% Exclusive to Flooded Caves Flooded Caves
Red Boom Fly.png
Squirt.png Dank Squirt.png 50% Exclusive to Dank Depths Dank Depths
Death's Head.png Dank Death's Head.png 50% Exclusive to Dank Depths Dank Depths
Globin.png Dank Globin.png 50% Exclusive to Dank Depths Dank Depths
Gazing Globin.png
Guts.png Scarred Guts.png 50% Exclusive to Scarred Womb Scarred Womb
Para-Bite.png Scarred Para-Bite.png 50% Exclusive to Scarred Womb Scarred Womb
Vis.png Scarred Double Vis.png 50% Exclusive to Scarred Womb Scarred Womb
Double Vis.png

Added in Afterbirth † Afterbirth+

Base Monster Replacement Chance Notes
Keeper.png Blister.png 10%
Ticking Spider.png 20%
Host.png Mushroom (Enemy).png 20%
Red Host.png
Hopper.png Ministro.png 20%
Trite.png
Nerve Ending.png Nerve Ending 2.png 20%
Brain.png Poison Mind.png 20%
Pale Fatty.png Stoney.png 10%
Wall Creep.png The Thing.png 20%
Blind Creep.png
Rage Creep.png
Mr Maw.png Mr. Red Maw.png 20%
Skinny.png Crispy.png 40% Exclusive to Burning Basement Burning Basement
Rottys do not appear in any Burning Basement room layouts, but can still be replaced regardless.
Rotty.png
Dank Charger.png Drowned Charger.png 50% Exclusive to Flooded Caves Flooded Caves
Dank Chargers do not appear in any Flooded Caves room layouts, but can still be replaced regardless.
Stoney.png Cross Stoney.png 20% Exclusive to Aprils Fool challenge

Added in Repentance Repentance

Base Monster Replacement Chance Notes
Horf.png Sub Horf.png Unknown In floors other than Downpour Downpour


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