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Monsters refers to the many antagonistic creatures and entities the player will encounter throughout the game.

Most monsters (with few exceptions) will damage Isaac by either touching him or shooting him with projectiles. Less frequently, monsters will spawn additional, lesser monsters, spread creep, or attempt to affect the player's movement. Some monsters become tougher the further along they're encountered. Along with the more common variety of monsters, champion versions can be found lurking about; These monsters are often like their common counterparts, but have a color tint or size change, more health, and drop basic pickups on death. There are also champion versions of most bosses.

There are 196 naturally spawning monsters in total. 40 of them were added in Afterbirth and 21 were added in Afterbirth † (13 were added in Booster Packs). Almost all of these naturally spawning entities are featured in the (in Afterbirth † and Repentance) Bestiary.

Monster List[ | ]

Entity ID Description
Frowning Gaper
Frowning Gaper
10.0 Walks towards Isaac, dealing contact damage. They start out with their eyes closed, but when they gain line of sight with Isaac, their eyes open and they permanently move faster. Usually turns into a PacerPacer or a GusherGusher upon death.
Gaper
Gaper
10.1 Walks towards Isaac, dealing contact damage. Usually turns into a PacerPacer or a GusherGusher upon death.
Flaming Gaper
Flaming Gaper
(except in Rebirth)
10.2 Walks towards Isaac, dealing contact damage. Usually turns into a PacerPacer or GusherGusher upon death.
Rotten Gaper
Rotten Gaper
(in Repentance)
10.3 Walks toward Isaac, dealing contact damage. Its behavior varies slightly depending on its facial expression.
Gurgle
Gurgle
87.0 Walks towards Isaac, dealing contact damage and periodically firing Collectible Ipecac iconIpecac shots at him; they are immune to this explosion, but other enemies are not. Can turn into a SplasherSplasher upon death.
Crackle
Crackle
(in Repentance)
87.1 Walks toward Isaac, dealing contact damage and spitting fireballs that create lines of fire in the cardinal directions on impact.
Nulls
Nulls
252.0 Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes, though its speed doesn't change. Fades into and out of visibility.
Cyclopia
Cyclopia
(except in Rebirth)
284.0 Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Blue Gaper
Blue Gaper
(except in Rebirth)
297.0 Walks towards Isaac, dealing contact damage.
Greed Gaper
Greed Gaper
(except in Rebirth)
299.0 Walks towards Isaac, dealing contact damage.
Wraith
Wraith
(in Repentance)
807.0 Walks toward Isaac, dealing contact damage. They are invisible and can only be seen through the reflection they cast in the water, or the ripples they make as they walk.
Deep Gaper
Deep Gaper
(in Repentance)
811.0 Emerges from the floor once all previous enemies have been killed, then proceeds to chase Isaac. Deals contact damage.
Blurb
Blurb
(in Repentance)
813.0 Walks slowly towards Isaac, dealing contact damage. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly. Can turn into a PacerPacer or GusherGusher upon death.
Level 2 Gaper
Level 2 Gaper
(in Repentance)
850.0 Walks towards Isaac, dealing a full Heart of contact damage. Splits into a Level 2 HorfLevel 2 Horf and Level 2 GusherLevel 2 Gusher upon death.
Level 2 Horf
Level 2 Horf
(in Repentance)
850.1 Slowly floats toward Isaac, spitting Small MaggotSmall Maggots at him.
Level 2 Gusher
Level 2 Gusher
(in Repentance)
850.2 Runs aimlessly around the room, spitting up Small Maggots.
Twitchy
Twitchy
(in Repentance)
851.0 Alternates between walking towards and rapidly leaping at Isaac, dealing contact damage. Can leap to Isaac's current position, or where Isaac is heading, and can also leap away to dodge incoming fire.
Dead Isaac
Dead Isaac
(in Repentance)
912.20 Summoned by Boss Mother secondphase ingameMother at the bottom of the arena, they walk upward (ignoring Isaac completely), and deal contact damage. Releases a burst of blood shots upon being killed by Mother, while she launches their corpses towards Isaac.
Faceless
Faceless
(in Repentance)
827.0 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots more frequently after taking damage.
Tainted Faceless
Tainted Faceless
(in Repentance)
827.1 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots very frequently after taking damage.
Exorcist
Exorcist
(in Repentance)
832.0 Summons Boss The Heretic ingameThe Heretic before transforming into Fanatics.
Fanatic
Fanatic
(in Repentance)
832.1 Transformed into from ExorcistExorcists. Chases Isaac and occasionally fires two purple, rotating shots.
Dump
Dump
(in Repentance)
876.0 Slides toward Isaac, leaving a trail of slippery brown creep. After taking enough damage, its head slides off and quickly bounces around the room and its body spews out brown shots until it empties.
Dump Head
Dump Head
(in Repentance)
876.1 Quickly slides toward Isaac, leaving a trail of slippery brown creep. Can spawn on its own or be created by a Dump after it takes enough damage.
Gusher
Gusher
11.0 Walks aimlessly around the room, occasionally firing a short-ranged blood shot.
Pacer
Pacer
11.1 Walks aimlessly around the room.
Splasher
Splasher
238.0 Walks aimlessly around the room, firing Ipecac shots in random directions.
Black Globin's Body
Black Globin's Body
(except in Rebirth)
280.0 Walks aimlessly around the room, occasionally spawning spiders.
Horf
Horf
12.0 Stationary enemy that fires a medium-ranged blood shot at Isaac when he gets in range of them.
Psychic Horf
Psychic Horf
248.0 Stationary enemy that fires a homing shot at Isaac when he gets in range of them.
Sub Horf
Sub Horf
(in Repentance)
812.0 Stationary enemy that spins and fires shots while being moved around or knocked back.
Tainted Sub Horf
Tainted Sub Horf
(in Repentance)
812.1 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Necro
Necro
(in Repentance)
828.0 Stationary enemy that summons unlimited-ranged bones to attack Isaac.
Fly
Fly
13.0 Hovers in place. Does not deal contact damage and is harmless, but can turn into PooterPooters if they stay around PoopPoop.
Attack Fly
Attack Fly
18.0 Red fly that follows Isaac and deals contact damage.
Moter
Moter
80.0 Follows Isaac, similar to Attack FlyAttack Flies. Deals contact damage. Splits into 2 Attack Flies upon death.
Eternal Fly
Eternal Fly
96.0 Invulnerable fly that circles Corny PoopCorny Poop and various monsters. Deals contact damage. Turns into a vulnerable Attack FlyAttack Fly after the object or monster it circles is destroyed.
Ring Fly
Ring Fly
222.0 Gathers with any other Ring Flies in the room. These flies orbit around themselves while following Isaac. Deals contact damage.
Dart Fly
Dart Fly
(except in Rebirth)
256.0 Flies towards Isaac and attempts to predict his movements. Deals contact damage.
Swarm
Swarm
(except in Rebirth)
281.0 Follows Isaac in large, tightly-clustered groups and deals contact damage.
Hush Fly
Hush Fly
(except in Rebirth)
296.0 Gathers with other Hush Flies to form certain patterns. If spawned by Boss Hush ingameHush, can chase Isaac or orbit Hush. Deals contact damage.
Willo
Willo
(in Repentance)
808.0 Flies in a circle around Isaac (in formation with other Willos if available), keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Army Fly
Army Fly
(in Repentance)
868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room. Deals contact damage.
Ultra Famine Fly
Ultra Famine Fly
(in Repentance)
951.11 Charges at Isaac at a delay. Deals contact damage. Spawned by Boss Ultra Famine ingameUltra Famine.
Ultra Pestilence Fly
Ultra Pestilence Fly
(in Repentance)
951.21 Flies in swarms around Boss Ultra Pestilence ingameUltra Pestilence, blocking shots and dealing contact damage.
Fly Bomb
Fly Bomb
(in Repentance)
819.0 Flies toward Isaac, circling around him as it does. Turn into a tiny BombBomb upon death.
Eternal Fly Bomb
Eternal Fly Bomb
(in Repentance)
819.1 Orbits Boom FlyBoom Flies spawned by Boss The Horny Boys ingameThe Horny Boys. Once its Boom Fly has been killed, turns into a tiny BombBomb.
Sucker
Sucker
61.0 Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit
Spit
61.1 Flies slowly towards Isaac, firing an Collectible Ipecac iconIpecac shot towards Isaac upon death.
Ink
Ink
(in Repentance)
61.3 Flies slowly towards Isaac. Fires four shots in the ordinal directions and leaves a puddle of slowing Black Creep upon death.
Soul Sucker
Soul Sucker
(in Afterbirth † and Repentance)
61.2 Flies slowly towards Isaac. Spawns a vortex that fires four Collectible Brimstone iconBrimstone beams in the cardinal directions upon death.
Mama Fly
Mama Fly
(in Repentance)
61.4 Flies more-or-less away from Isaac, occasionally plopping on the ground to plant a PustulePustule. Upon death, they spawn a group of Small MaggotSmall Maggots.
Bulb
Bulb
(in Repentance)
61.5 Flies in erratic, angled movements toward Isaac if his active item has charges; on contact, they drain up to 2 charges, but never deal contact damage. If he has no active item, or no charges, they wander around the room aimlessly.
Bloodfly
Bloodfly
(in Repentance)
61.6 Spawned only after a PustulePustule bursts. Flies in erratic, angled movements toward Isaac. Fires four blood shots in the cardinal directions upon death.
Tainted Sucker
Tainted Sucker
(in Repentance)
61.7 Flies slowly towards Isaac. Upon death, fires a radial burst of six blood shots that each also fires a radial burst of six blood shots.
Pooter
Pooter
14.0 Slowly drifts toward Isaac, occasionally firing a single blood shot at him. Does not deal contact damage.
Super Pooter
Super Pooter
14.1 Slowly drifts toward Isaac, occasionally firing two blood shots in a V-formation at him. Does not deal contact damage.
Tainted Pooter
Tainted Pooter
(in Repentance)
14.2 Slowly drifts toward Isaac, occasionally firing four blood shots at him that split into two smaller ones when they hit a wall or obstacle.
Clotty
Clotty
15.0 Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Clot
Clot
15.1 Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I.Blob
I
15.2 Randomly wanders around the room, firing 8 shots in all directions.
Grilled Clotty
Grilled Clotty
(in Repentance)
15.3 Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.
Cloggy
Cloggy
(in Repentance)
872.0 Randomly wanders around the room, firing four curved brown shots in the cardinal directions. These shots alternate between rotating clockwise and counterclockwise with each shot.
Mulligan
Mulligan
16.0 Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be FlyFlies, Attack FlyAttack Flies, and/or PooterPooters. Can self-detonate and launch four projectiles in the cardinal directions while still releasing flies.
Mulligoon
Mulligoon
16.1 Walks around the room, avoiding Isaac. Upon death, spawns a Troll BombTroll Bomb and fires four shots in the ordinal directions. Can self-detonate, spawn a Troll bomb, and launch eight projectiles in all directions.
Mulliboom
Mulliboom
16.2 Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive
Hive
22.0 Wanders around the room, avoiding Isaac and spawning Attack FlyAttack Flies if he gets close. Spawns a large number of flies on death, which can be FlyFlies, Attack FlyAttack Flies, and/or PooterPooters.
Drowned Hive
Drowned Hive
(except in Rebirth)
22.1 Wanders around the room, avoiding Isaac and spawning Drowned ChargerDrowned Chargers if he gets close. Spawns 0-2 Drowned Chargers upon death.
Holy Mulligan
Holy Mulligan
(in Repentance)
22.2 Wanders around the room, avoiding Isaac and spawning Angelic Baby (small)Angelic Baby (small) if he gets close. Spawns 1-2 EmbryoEmbryos upon death.
Tainted Mulligan
Tainted Mulligan
(in Repentance)
22.3 Wanders around the room, avoiding Isaac and spawning 6 Ring FlyRing Flies if he gets close. Spawns a plethora of fly enemies upon death.
Nest
Nest
205.0 Wanders around the room, avoiding Isaac and spawning SpiderSpiders if he gets close. Spawns a Big SpiderBig Spider or TriteTrite upon death.
Leper
Leper
(in Afterbirth † and Repentance)
310.0 Alternating between walking towards and running away from Isaac. Releases a Leper Flesh each time it takes enough damage. At low health, constantly chases Isaac and leaves behind damaging red creep. Spawns a Leper Flesh and GusherGusher upon death.
Leper Flesh
Leper Flesh
(in Afterbirth † and Repentance)
310.1 Floats slowly toward Isaac and fires a predictive projectile at him upon death.
Prey
Prey
(in Repentance)
817.0 Wanders around the room, avoiding Isaac and spawning Small LeechSmall Leeches if he gets close. Spawns 3 Small Leeches upon death.
Mullighoul
Mullighoul
(in Repentance)
817.1 Wanders around the room, avoiding Isaac and spawning WilloWillos if he gets close. Spawns 1-2 Willos upon death.
Bouncer
Bouncer
(in Repentance)
822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Gas Dwarf
Gas Dwarf
(in Repentance)
874.0 Chases Isaac, periodically coughing up gas clouds. On death, fires an explosive shot that can detonate gas clouds it hits.
Danny
Danny
(in Repentance)
820.0 Walks toward Isaac and spits chaotic bursts of rocks at him, some of which may be Rock SpiderRock Spiders.
Coal Boy
Coal Boy
(in Repentance)
820.1 Walks toward Isaac and spits hot coals at him, some of which may be Coal SpiderCoal Spiders.
Blaster
Blaster
(in Repentance)
821.0 Slowly wanders around and occasionally shoots Fly BombFly Bombs at Isaac.
Maggot
Maggot
21.0 Aimlessly moves around the room, dealing contact damage.
Charger
Charger
23.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight.
My Shadow
My Shadow
(except in Rebirth)
23.0.1 Charges at enemies when in its line of sight, dealing contact damage. Will always spawn friendly via Collectible My Shadow iconMy Shadow.
Drowned Charger
Drowned Charger
(except in Rebirth)
23.1 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Charger
Dank Charger
(in Afterbirth † and Repentance)
23.2 Slowly moves around the room, launching itself at Isaac if he gets in its line of sight. Bounces off of walls and leaves a trail of slowing Black Creep while charging.
Carrion Princess
Carrion Princess
(in Repentance)
23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech
(in Repentance)
810.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Small Maggot
Small Maggot
(in Repentance)
853.0 Slowly crawls toward Isaac, dealing contact damage.
Level 2 Charger
Level 2 Charger
(in Repentance)
855.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Elleech
Elleech
(in Repentance)
855.1 Slowly moves around the room. After Isaac gets in its line of sight, continuously charges at him in the closest cardinal direction.
Blood Puppy
Blood Puppy
(in Repentance)
802.0 Quickly moves around the room, attacking and charging at other monsters and Isaac when they get in its line of sight.
Spitty
Spitty
31.0 Slowly moves around the room, occasionally firing a single blood shot forward.
Tainted Spitty
Tainted Spitty
(in Repentance)
31.1 Slowly moves around the room, firing chaotic bursts of blood shots in all directions and occasionally spitting a line of blood shots in the direction it's facing. Fires two rotating rings of blood shots upon death.
Conjoined Spitty
Conjoined Spitty
243.0 Slowly moves around the room, occasionally firing a blood shot from both ends of its body.
Globin
Globin
24.0 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin
Gazing Globin
24.1 Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which will slide away from Isaac and can be killed. Will regenerate after a short period of time if not killed quickly.
Dank Globin
Dank Globin
(except in Rebirth)
24.2 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a SpiderSpider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Cursed Globin
Cursed Globin
(in Repentance)
24.3 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into 1-2 piles of goo, each of which can be killed and regenerate after a short period of time if not killed quickly. These goo piles have less health the more times the Cursed Globin splits.
Black Globin
Black Globin
(except in Rebirth)
278.0 Chases Isaac, dealing a full heart of contact damage and launching SpiderSpiders towards Isaac whenever it takes damage. Spawns a Spider, a Black Globin's HeadBlack Globin's Head, and a Black Globin's BodyBlack Globin's Body upon death.
Clickety Clack
Clickety Clack
(in Repentance)
889.0 Walks towards Isaac and turn into a pile of bones when killed. Regenerates a few seconds after killed. Will only despawn if all Clickety Clacks in the room are killed.
Gasbag
Gasbag
(in Repentance)
856.0 Occasionally summons Army FlyArmy Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Cohort
Cohort
(in Repentance)
857.0 Acts similarly to Boss Monstro ingameMonstro, hopping towards Isaac and can either spit a large projectile towards Isaac that bursts into 8 smaller projectiles or cough up a burst of arcing projectiles and a pile of GlobinGlobin goo. Spawns 4 piles of Globin goo upon death.
Boom Fly
Boom Fly
25.0 Flies across the room in straight diagonal lines, dealing contact damage. Explodes upon death.
Red Boom Fly
Red Boom Fly
25.1 Flies across the room in straight diagonal lines, dealing contact damage. Creates a ring of 6 blood shots upon death.
Drowned Boom Fly
Drowned Boom Fly
(except in Rebirth)
25.2 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, explodes and fires four blood shots in the cardinal directions. Also has a chance to spawn a Drowned ChargerDrowned Charger upon death. A hit on this fly will change it's direction to the opposite side.
Dragon Fly
Dragon Fly
(in Repentance)
25.3.0 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, creates four lines of fire in the cardinal directions; the fire nearly spans the length of an entire normal-sized room.
Dragon Fly X
Dragon Fly X
(in Repentance)
25.3.1 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, creates four lines of fire in the ordinal directions; the fire nearly spans the length of an entire normal-sized room.
Bone Fly
Bone Fly
(in Repentance)
25.4 Flies across the room in straight diagonal lines, dealing contact damage. Fires bones at Isaac if he lines up with it in the cardinal directions. Fires a radial burst of 3 bones upon death.
Sick Boom Fly
Sick Boom Fly
(in Repentance)
25.5 Flies across the room in straight diagonal lines, dealing contact damage and trailing poisonous gas. Upon death, explodes into a gas cloud and fires a ring of 6 green shots.
Tainted Boom Fly
Tainted Boom Fly
(in Repentance)
25.6 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, it glows brightly, warning that it is about to explode; this explosion sends 4 lines of further explosions in the cardinal directions, which span the length of the room.
Maw
Maw
26.0 Slowly floats towards Isaac, firing a blood shot at him when he is in their range.
Red Maw
Red Maw
26.1 Floats quickly towards Isaac and releases 4 blood shots in the cardinal directions upon death.
Psychic Maw
Psychic Maw
26.2 Slowly floats towards Isaac, firing homing shots at him when he is in their range. Spawns with an Eternal Fly orbiting around it.
Host
Host
27.0 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots in a spread and lower its head again.
Red Host
Red Host
27.1 Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Hard Host
Hard Host
(in Repentance)
27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Shortly after raising its head, it slams its head down and fires a rock wave towards Isaac.
Mobile Host
Mobile Host
204.0 Acts like the Host, but follows Isaac and deals contact damage.
Flesh Mobile Host
Flesh Mobile Host
247.0 Acts like the Red Host, but follows Isaac and deals contact damage.
Floast
Floast
(in Repentance)
859.0 Floats diagonally around the room and is normally invulnerable. When Isaac gets close, reveals a fleshy stem that can be damaged and fires 3 blood shots in an angle at him before hiding its stem again.
Mushroom
Mushroom
(in Afterbirth † and Repentance)
300.0 Stationary enemy that occasionally pops up and fires four shots in the cardinal or diagonal directions. Takes less damage while its head is down.
Hopper
Hopper
29.0 Slowly hops around the room, doing contact damage. Can turn into a Flaming Hopper by jumping into Fire PlaceFire Places or other fires.
Eggy
Eggy
(in Repentance)
29.2 Hops aimlessly around the room, spawning slowing white creep wherever it hops. Spawns a group of Swarm SpiderSwarm Spiders upon death.
Tainted Hopper
Tainted Hopper
(in Repentance)
29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Leaper
Leaper
34.0 Hops around the room, doing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
Sticky Leaper
Sticky Leaper
(in Repentance)
34.1 Hops around the room, dealing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while creating a chaotic burst of tar shots in all directions and a puddle of slowing black creep.
Flaming Hopper
Flaming Hopper
54.0 Quickly hops around the room, doing contact damage. Covers a larger distance than the regular Hopper.
Trite
Trite
29.1 Quickly leaps towards Isaac and deals contact damage.
Ragling
Ragling
246.0 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Rag Man's Ragling
Rag Man's Ragling
(except in Rebirth)
246.1 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Blister
Blister
(in Afterbirth † and Repentance)
303.0 Slowly hops towards Isaac, occasionally spawning a Dark Ball. Spawns a SackSack upon death.
Boil
Boil
30.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut
Gut
30.1 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Collectible Ipecac iconIpecac shots in random directions when fully swollen.
Sack
Sack
30.2 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns SpiderSpiders when fully swollen.
Blue Boil
Blue Boil
(except in Rebirth)
298.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Gush
Gush
(in Afterbirth † and Repentance)
309.0 Stationary, harmless enemy that continually creates slowing black creep.
Pustule
Pustule
(in Repentance)
861.0 Slowly increases in size over time, spawning Small MaggotSmall Maggots and damaging red creep depending on its size upon death. If it grows to full size, it transforms into a BloodflyBloodfly.
Walking Boil
Walking Boil
88.0 Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut
Walking Gut
88.1 Does not shrink or regenerate. Walks around aimlessly and fires Collectible Ipecac iconIpecac shots in random directions.
Walking Sack
Walking Sack
88.2 Does not shrink or regenerate. Walks around aimlessly and occasionally spawns SpiderSpiders.
Brain
Brain
32.0 Slowly crawls around the room, leaving a trail of Red Creep.
Black Globin's Head
Black Globin's Head
(except in Rebirth)
279.0 Slides towards Isaac, leaving a trail of damaging Red Creep.
Festering Guts
Festering Guts
(in Repentance)
831.20 Spawned by Gutted FattyGutted Fatties, Festering Guts randomly slide around the room and occasionally spawn a ChargerCharger.
Poison Mind
Poison Mind
(in Afterbirth † and Repentance)
301.0 Slowly (except in Repentance)crawls/(in Repentance)floats around the room diagonally, leaving a trail of damaging green creep. (in Repentance) Explodes upon death.
Pon
Pon
(in Repentance)
840.0 Hops around the room, leaving damaging red creep wherever it lands. Upon death, its associated Brainless KnightBrainless Knight dies with it.
Gyro
Gyro
(in Repentance)
824.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles as it does.
Grilled Gyro
Grilled Gyro
(in Repentance)
824.1 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles and creating fires behind itself as it does.
Mr. Maw
Mr
35.0 Walks towards Isaac and attacks by launching its head towards him. Turns into a MawMaw or GusherGusher upon death depending on the killed body segment. Occasionally separates at will.
Mr. Red Maw
Mr
(in Afterbirth † and Repentance)
35.2 Walks towards Isaac and attacks by launching its head towards him. Turns into a Red MawRed Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Swinger
Swinger
216.0 Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a MawMaw or a GlobinGlobin depending on which part is killed.
Mr. Mine
Mr
(in Afterbirth † and Repentance)
311.0 Can only appear in pits. Attempts to launch itself at Isaac if he comes near. Occasionally burrows and pops up in another pit, and fires six shots in all directions upon death.
Baby
Baby
38.0 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere.
Angelic Baby
Angelic Baby
38.1.0 Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
Angelic Baby (small)
Angelic Baby (small)
(in Repentance)
38.1.1 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere. Can only be spawned by Holy Mulligans.
Wrinkly Baby
Wrinkly Baby
(in Repentance)
38.3 Dashes towards Isaac at high speed and fires three blood shots in his direction once stopped.
Imp
Imp
(except in Rebirth)
259.0 Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Unborn
Unborn
(in Repentance)
860.0 Floats quickly towards Isaac, and occasionally teleports to another position near him.
Baby Begotten
Baby Begotten
(in Repentance)
883.0 Floats toward Isaac, avoiding his shots. After getting close, fires a short Collectible Brimstone iconBrimstone laser in the closest cardinal direction and propels itself away from him.
Vis
Vis
39.0 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser when Isaac gets in its line of sight.
Double Vis
Double Vis
39.1 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
Chubber
Chubber
39.2 Randomly wanders around the room. Pauses to fire a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, has limited range, and flies back to the Chubber.
Scarred Double Vis
Scarred Double Vis
(except in Rebirth)
39.3 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Vis Versa
Vis Versa
(in Repentance)
836.0 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis
(in Repentance)
865.0 Randomly wanders around the room. Launches a string of guts when Isaac gets close to it, which it uses to pull Isaac toward itself.
Guts
Guts
40.0 Attaches itself to a wall or obstacle and rolls around it.
Scarred Guts
Scarred Guts
(except in Rebirth)
40.1 Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Slog
Slog
(in Repentance)
40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst
(in Repentance)
862.0 Attaches itself to a wall or obstacle and rolls around it, regularly firing blood shots at Isaac.
Knight
Knight
41.0 Moves erratically around the room and charges towards Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight
Selfless Knight
41.1 Moves erratically around the room and charges towards Isaac very quickly when in line of sight. Can only be damaged from behind.
Loose Knight
Loose Knight
(in Repentance)
41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When its health is depleted, it turns into a Brainless Knight and a PonPon.
Brainless Knight
Brainless Knight
(in Repentance)
41.3 Alternates between running around the room along the cardinal directions and aimlessly walking in circles. Charges at Isaac when in line of sight. Dies when its corresponding PonPon dies.
Black Knight
Black Knight
(in Repentance)
41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon charging into an obstacle. Shots that hit it from the front are deflected back at Isaac.
Floating Knight
Floating Knight
254.0 Behaves like the Knight but slower, and can fly over all obstacles.
Bone Knight
Bone Knight
(except in Rebirth)
283.0 Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Whipper
Whipper
(in Repentance)
834.0 Runs around the room, sprinting at Isaac when he gets in its line of sight and lashing at him when it gets close.
Snapper
Snapper
(in Repentance)
834.1 Runs around the room, sprinting at Isaac when he gets in its line of sight and throwing out its whip when he gets in range.
Flagellant
Flagellant
(in Repentance)
834.2 Runs around the room. When Isaac gets in its line of sight, continuously chases him and lashes its whip, occasionally deflecting Isaac’s shots.
Dople
Dople
53.0 Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin
Evil Twin
53.1 Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Leech
Leech
55.0 Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech
Kamikaze Leech
55.1 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech
Holy Leech
55.2 Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it, which instantly dies when the Holy Leech explodes.
Adult Leech
Adult Leech
(in Repentance)
854.0 Wanders around the room, quickly charging at Isaac when he lines up horizontally with him and releasing a ring of blood shots upon colliding with a wall. After taking a certain amount of damage, burrows into the ground and reappears by falling above Isaac, releasing another ring of blood shots and only performing this behavior once.
Lump
Lump
56.0 Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing.
Tar Boy
Tar Boy
(in Afterbirth † and Repentance)
307.0 Fires a short-ranged spray of shots that leave behind slowing Black Creep. Occasionally burrows underground and reappears under any pools of black creep in the room. If Isaac stands on the Creep, the Tar Boy can (except in Repentance) fire shots straight upwards out of the Creep underneath Isaac/(in Repentance) send out a tentacle underneath Isaac.
MemBrain
MemBrain
57.0 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 BrainBrains upon death.
Mama Guts
Mama Guts
57.1 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 GutsGuts upon death.
Dead Meat
Dead Meat
(in Repentance)
57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 CystCysts upon death.
Dinga
Dinga
223.0 Slowly moves around the room, occasionally hopping to spawn DipDips or fire 8 Brown shots in all directions. Splits 2 SquirtSquirts upon death.
Mega Clotty
Mega Clotty
(except in Rebirth)
282.0 Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a ClottyClotty or a collapsed GlobinGlobin. Splits into two ClottyClotties upon death.
Para-Bite
Para-Bite
58.0 Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
Scarred Para-Bite
Scarred Para-Bite
(except in Rebirth)
58.1 Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Fred
Fred
59.0 Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Eye
Eye
60.0 Slowly turns towards Isaac and fires a Technology laser at Isaac if he stands still or is too slow.
Bloodshot Eye
Bloodshot Eye
60.1 Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Holy Eye
Holy Eye
(in Repentance)
60.2 Rapidly summons several beams of light around Isaac every few seconds.
Embryo
Embryo
77.0 Aimlessly hops around the room, dealing contact damage.
Spider
Spider
85.0 Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage.
Big Spider
Big Spider
94.0 Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage. Spawns two Spiders upon death.
Strider
Strider
(in Repentance)
814.0 Erratically swims around the room. If it sees Isaac, it chases him, trying to deal contact damage.
Rock Spider
Rock Spider
(in Repentance)
818.0 Slowly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Spider upon death. Turns into a Coal Spider if it touches fire.
Tinted Rock Spider
Tinted Rock Spider
(in Repentance)
818.1 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Soul Heart upon death. Can only spawn by breaking tinted rocks on Mines or Ashpit.
Coal Spider
Coal Spider
(in Repentance)
818.2 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a hot coal upon death that blocks shots and deals contact damage, but can be destroyed.
Swarm Spider
Swarm Spider
(in Repentance)
884.0 Very erratically hops toward Isaac in large groups, dealing contact damage.
Keeper
Keeper
86.0 Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Buttlicker
Buttlicker
89.0 Can start attached to other Buttlickers and erratically moves around the room, similar to Boss Larry Jr. ingameLarry Jr..
Butt Slicker
Butt Slicker
(in Repentance)
878.0 Moves erratically around the room unless attached to another Butt Slicker. Grouped Butt Slickers drag themselves towards Isaac, and when an individual is killed they leave black creep, and shoot out black projectiles. The amount of projectiles released and the size of the pool of Black Creep is determined by the amount of Butt Slickers attached.
Hanger
Hanger
90.0 Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an Eternal FlyEternal Fly circling around it.
Swarmer
Swarmer
91.0 Slowly floats around the room, spawning several Attack FlyAttack Flies. Spawns PooterPooters upon taking damage. Spawns a Boom FlyBoom Fly upon death.
Mask + Heart
Mask + Heart
93.0 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Mask II + 1/2 Heart
Mask II + 1/2 Heart
(in Repentance)
93.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Baby Long Legs
Baby Long Legs
206.0 Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs
Small Baby Long Legs
206.1 Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs
Crazy Long Legs
207.0 Chases Isaac, dealing touch damage. Occasionally stops to spit 8 blood shots in all directions.
Small Crazy Long Legs
Small Crazy Long Legs
207.1 Chases Isaac, dealing touch damage. Occasionally stops to spit 4 blood shots in the diagonal directions.
Fatty
Fatty
208.0 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
Pale Fatty
Pale Fatty
208.1 Slowly walks towards Isaac. Occasionally farts and shoots 6 blood shots in all directions. Has a chance to turn into a Blubber upon death.
Flaming Fatty
Flaming Fatty
(except in Rebirth)
208.2 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away (in Repentance) and spawns a damaging flame. Has a chance to leave behind a damaging flame upon death.
Fat Sack
Fat Sack
209.0 Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of Red Creep and shooting 6 blood shots in all directions where it lands. Has a chance to turn into a Blubber upon death.
Blubber
Blubber
210.0 Walks around aimlessly and randomly spews a cluster of blood shots in all directions. Has a chance to turn into a Half Sack when killed.
Half Sack
Half Sack
211.0 Wanders around aimlessly and leaves a trail of Red Creep.
Conjoined Fatty
Conjoined Fatty
(except in Rebirth)
257.0 Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty
(except in Rebirth)
257.1 Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Stoney
Stoney
(in Afterbirth † and Repentance)
302.0 Chases Isaac and blocks tears, but does not deal contact damage. Temporarily pauses in exhaustion after a certain amount of time. Invulnerable; dies when the room is cleared.
Cross Stoney
Cross Stoney
(in Afterbirth † and Repentance)
302.10 Chases Isaac and shoots 4 tears vertically and diagonally like a Cross Stone ShooterCross Stone Shooter. Dies when the room is cleared.
Only appears in Aprils Fool (challenge #32) as replacements to regular Stoneys.
Bubbles
Bubbles
(in Repentance)
806.0 Slowly walks towards Isaac, firing back shots upon taking damage. Occasionally farts, which pushes Isaac and adjacent enemies away and creates a chaotic burst of shots. Creates a geyser of water shots upon death.
Quakey
Quakey
(in Repentance)
823.0 Walks slowly toward Isaac, occasionally attempting to jump on Isaac, shooting out 8 rock shots when it hits the ground and causing rocks to fall from the ceiling.
Big Bony
Big Bony
(in Repentance)
830.0 Walks slowly toward Isaac, and will occasionally fire a bone that bounces around the room for a few moments. The bone can be broken if shot enough.
Gutted Fatty
Gutted Fatty
(in Repentance)
831.0 Slowly lumbers around the room, occasionally spawning Festering GutsFestering Guts. Its eyes dislocate as it takes damage, which are invincible and follow the Gutted Fatty but chase Isaac if he gets close to them. Creates a geyser of blood projectiles upon death.
Gutted Fatty Eye
Gutted Fatty Eye
(in Repentance)
831.10 Invulnerable enemy spawned by Gutted Fatties. Hovers around their correlating Gutted Fatty unless Isaac draws near, after which it will chase Isaac, blocking tears and dealing contact damage.
Peeping Fatty
Peeping Fatty
(in Repentance)
835.0 Has two indestructible Peeping Fatty Eyes that are out of their sockets but attached by muscles. Wanders around the room randomly, or toward Isaac if its eyes see him. Occasionally farts and fires a radial burst of 6 blood shots.
Peeping Fatty Eye
Peeping Fatty Eye
(in Repentance)
835.10 Invulnerable enemy attached to a Peeping Fatty. Follows Isaac when in line of sight, blocking tears and dealing contact damage.
Bloaty
Bloaty
(in Repentance)
879.0 Lumbers around, occasionally spitting green shots and a line of damaging green creep in a random direction.
Vis Fatty
Vis Fatty
(in Repentance)
886.0 Spawns with a Fetal Demon attached to it and slowly walks towards Isaac. Will occasionally fart, briefly pushing the demon away and spawning creep around itself and the demon. If the demon is killed first, the Fatty will shoot out Collectible Brimstone iconBrimstone in the diagonal direction closest to Isaac. It will then fly around the room diagonally, bumping off of walls and tall blocks all while continuously firing Collectible Brimstone iconBrimstone behind it.
Fetal Demon
Fetal Demon
(in Repentance)
886.1 Usually encountered tethered to Vis FattyVis Fatties. When tethered it makes short lunges towards Isaac if he gets close. If the Vis Fatty is killed or when encountered alone it will chase Isaac similarly to Boss Gemini ingameGemini's Suture.
Shady
Shady
(in Repentance)
888.0 Walks slowly toward Isaac, occasionally firing a shot that creates shots perpendicular to itself while traveling and splits into a ring of shots upon hitting a wall or obstacle. Also occasionally jumps, creating lines of explosions in the cardinal directions. One of the few enemies that utilize Damage Scaling.
Death's Head
Death's Head
212.0 Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Dank Death's Head
Dank Death's Head
(except in Rebirth)
212.1 Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Cursed Death's Head
Cursed Death's Head
(in Repentance)
212.2 Invulnerable enemy that moves diagonally around the room, dealing contact damage. If Isaac enters its purple aura, he will be inflicted with fear and be temporarily unable to shoot. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head
(in Repentance)
212.3 Invulnerable enemy that moves diagonally around the room, pausing to fire a Collectible Brimstone iconBrimstone laser when Isaac lines up with it in the cardinal directions. Dies when the room is cleared.
Redskull
Redskull
(in Repentance)
212.4 Moves diagonally around the room, creating a ring of fire around itself if Isaac gets close to it. Can be killed, but also dies when the room is cleared.
Flesh Death's Head
Flesh Death's Head
(except in Rebirth)
286.0 Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head
(in Repentance)
887.0 Invulnerable enemy that moves across the room in a waving motion in large quantities. Dies when the room is cleared.
Ultra Death Head
Ultra Death Head
(in Repentance)
951.42 Invulnerable enemy spawned by Boss Ultra Death ingameUltra Death that moves across the room in a waving motion in large quantities as a part of one of his attacks. Dies upon the completion of the attack.
Mom's Hand
Mom's Hand
213.0 Falls from the ceiling. If it lands on Isaac, it deals damage and teleports him back to the spawn room of the floor. Entering a room containing Mom's Hand will warn Isaac with Mom's laugh.
Mom's Dead Hand
Mom's Dead Hand
(except in Rebirth)
287.0 Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn Isaac with Mom's laugh.
Level 2 Fly
Level 2 Fly
214.0 Flies toward Isaac erratically, dealing contact damage.
Full Fly
Full Fly
249.0 Flies toward Isaac erratically, dealing contact damage. Releases 6 bullets in all directions upon death.
Level 2 Willo
Level 2 Willo
(in Repentance)
838.0 Orbits enemies and shoots tears at Isaac. If the enemy it is orbiting dies, it will orbit another enemy. However, if all enemies are dead, it will chase Isaac, while still occasionally shooting at Isaac.
Level 2 Spider
Level 2 Spider
215.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances.
Ticking Spider
Ticking Spider
250.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Explodes upon death.
Migraine
Migraine
(in Repentance)
869.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Releases multiple Troll BombTroll Bombs upon death.
Dip
Dip
217.0 Slowly dashes in random directions, dealing contact damage.
Corn
Corn
(except in Rebirth)
217.1 Quickly dashes in random directions, dealing contact damage.
Brownie Corn
Brownie Corn
(except in Rebirth)
217.2 Quickly dashes in random directions, dealing contact damage.
Big Corn
Big Corn
(in Repentance)
217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Drip
Drip
(in Repentance)
870.0 Quickly rolls around in diagonal directions, dealing contact damage.
Wizoob
Wizoob
219.0 Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Red Ghost
Red Ghost
(except in Rebirth)
285.0 Disappears, then reappears near Isaac and fires a brimstone laser.
Squirt
Squirt
220.0 Dashes towards Isaac and deals contact damage. Spawns 2 Dips upon death.
Dank Squirt
Dank Squirt
(except in Rebirth)
220.1 Dashes towards Isaac and deals contact damage, creating slowing black creep. Spawns 2 Clots upon death.
Hardy
Hardy
(in Repentance)
826.0 Dashes toward Isaac and deals contact damage creating rock projectiles when it hits a wall/obstacle. It spawns more rock projectiles the more times it crashes into obstacles, dying after doing so a third time.
Splurt
Splurt
(in Repentance)
871.0 Dashes towards Isaac twice and deals contact damage. Spawns 2 Drips upon death.
Cod Worm
Cod Worm
221.0 Stationary enemy that hides in a shell and spews a burst of blood shots if shot at. Only vulnerable when it pops its head out.
Oob
Oob
224.0 When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw
Black Maw
225.0 When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Leeches. Explodes when it dies.
Skinny
Skinny
226.0 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself.
Rotty
Rotty
226.1 Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself. Spawns a BonyBony or two Attack FlyAttack Flies upon death.
Crispy
Crispy
(in Afterbirth † and Repentance)
226.2 Slowly walks towards Isaac, but increases in speed as they take damage. Constantly passively takes damage.
Bony
Bony
227.0 Wanders around the room and throws a bone at Isaac when he is in sight.
Holy Bony
Holy Bony
(in Repentance)
227.1 Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Black Bony
Black Bony
(except in Rebirth)
277.0 Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Revenant
Revenant
(in Repentance)
841.0 Slowly wanders around the room, stopping to fire a large line of fire at the player.
Quad Revenant
Quad Revenant
(in Repentance)
841.1 Wanders around the room slowly, stopping to fire lines of flames in the cardinal or ordinal directions, rotating in an attempt to hit Isaac.
Maze Roamer
Maze Roamer
(in Repentance)
890.0 Wanders around the room and shoots an eyeball at Isaac when he is in sight. Has a clone of itself on the other side of the room that mimics its movement and shots. If one dies, the other starts actively pursuing Isaac.
Homunculus
Homunculus
228.0 Starts attached to the wall or an (in Afterbirth † and Repentance) obstacle. After a while, it detaches, shooting 6 blood shots in all directions, leaving a puddle of Red Creep and chasing Isaac. If it dies while still attached, it will still leave a puddle of Red Creep.
Begotten
Begotten
251.0 Starts attached to the wall or an (in Afterbirth † and Repentance) obstacle. After a while, it detaches, firing 6 blood shots in all directions, turning the room dark, becoming invisible and chasing Isaac. Briefly becomes visible upon getting hit.
Tumor
Tumor
229.0 Moves around the room diagonally, occasionally firing 6 blood shots in all directions. Fires more often upon getting damaged.
Planetoid
Planetoid
(in Repentance)
229.1 Moves around the room diagonally, occasionally firing blood shots that orbit itself. Fires more shots and has a chance to send its ring of shots outward upon taking damage.
Camillo Jr.
Camillo Jr.
230.0 Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Psy Tumor
Psy Tumor
253.0 Moves around the room diagonally, occasionally firing 6 homing shots in all directions. Fires more often upon getting damaged.
Poofer
Poofer
(in Repentance)
892.0 Slowly floats toward Isaac, swells up and fire 6 blood shots in all directions upon taking damage. Explodes upon death, healing nearby enemies and leaving a big puddle of red creep.
Nerve Ending
Nerve Ending
231.0 Static enemy which acts as a meat shield.
Nerve Ending 2
Nerve Ending 2
(in Afterbirth † and Repentance)
231.1 Static enemy which whips at Isaac if he gets too close.
Bishop
Bishop
(in Repentance)
805.0 Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
One Tooth
One Tooth
234.0 Follows Isaac and periodically dashes towards him when it gets close. Deals contact damage.
Fat Bat
Fat Bat
(except in Rebirth)
258.0 Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Gurgling
Gurgling
237.0 Charges towards Isaac when he lines up with them, leaving a trail of Red Creep and shooting 6 blood shots.
Goat
Goat
(in Repentance)
891.0 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines up on either side of it.
Black Goat
Black Goat
(in Repentance)
891.1 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines upon either side of it. Can also fire thin Collectible Brimstone iconBrimstone lasers in the cardinal directions, along with all other Black Goats in the room.
Cultist
Cultist
(in Repentance)
885.0 Creates an indestructible, homing Purple BallPurple Ball at the start of the room and follows it around, occasionally leaving it to revive enemies that have died in the current room.
Blood Cultist
Blood Cultist
(in Repentance)
885.1 Wanders around the room and fires a line of blood shots and creep if Isaac is on either side of it. Can summons bone traps that temporarily ensnare Isaac if he walks into them.
Grub
Grub
239.0 Erratically moves around the room like Boss Larry Jr. ingameLarry Jr. and charges at Isaac when he gets within its line of sight. Spawns MaggotMaggots, ChargerChargers, or SpittySpitties upon death, one for each of its segments.
Wall Creep
Wall Creep
240.0 Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Soy Creep
Soy Creep
(in Repentance)
240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by Collectible Soy Milk iconSoy Milk.
Tainted Soy Creep
Tainted Soy Creep
(in Repentance)
240.3 Slowly crawls along walls to try to line up with Isaac and shoots a 4 diagonal streams of Collectible Soy Milk iconSoy Milk shots.
Rage Creep
Rage Creep
241.0 Slowly crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
Blind Creep
Blind Creep
242.0 Randomly crawls along walls and shoots three spread blood shots.
The Thing
The Thing
(in Afterbirth † and Repentance)
304.0 Crawls along a wall and attempts to line up with Isaac, then spits a line of damaging Red Creep.
Round Worm
Round Worm
244.0 Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Tube Worm
Tube Worm
(in Afterbirth † and Repentance)
244.1 Pops out of the ground in random locations and fires a long-range spray of arcing shots where Isaac will be.
Tainted Round Worm
Tainted Round Worm
(in Repentance)
244.2 Pops out of the ground in random locations alongside several tail ends. The head fires a large blood shot that splits into a radial burst of 8 blood shots, while the tail ends shoot normal blood shots.
Tainted Tube Worm
Tainted Tube Worm
(in Repentance)
244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Night Crawler
Night Crawler
255.0 Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
Roundy
Roundy
(except in Rebirth)
276.0 Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Ulcer
Ulcer
(except in Rebirth)
289.0 Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Fire Worm
Fire Worm
(in Repentance)
825.0 Pops out of the ground in random locations in the lava and fires one flame at Isaac.
Mole
Mole
(in Repentance)
829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole
(in Repentance)
829.1 Dig towards Isaac and release a ring of rock waves. Fires 3 blood shots at Isaac 4 times.
Lil' Haunt
Lil' Haunt
260.0 Floats toward Isaac and occasionally fires a blood shot at him, predicting his movements.
Polty
Polty
(in Repentance)
816.0 Picks up and throws rocks and props at Isaac.
Kineti
Kineti
(in Repentance)
816.1 Uses telekinesis to pick up and throw rocks and obstacles at Isaac.
Dust
Dust
(in Repentance)
882.0 Follows Isaac, and is only visible when close to Isaac. Will begin to speed up when they are visible. Teleports away after taking enough damage.
Dukie
Dukie
(except in Rebirth)
288.0 Flies around the room diagonally, occasionally spitting out 1-2 Dart FlyDart Flies.
Meatball
Meatball
(except in Rebirth)
290.0 Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Ministro
Ministro
(in Afterbirth † and Repentance)
305.0 Hops around randomly and hop towards Isaac when he gets close, occasionally spitting out a cluster of disorganized shots.
Fistuloid
Fistuloid
(in Afterbirth † and Repentance)
308.0 Flies towards Isaac in an erratic waving motion, periodically firing a blood shot towards Isaac that also knocks itself back. Upon death, fires a worm that flies off screen.
Fly Trap
Fly Trap
(in Repentance)
873.0 Floats towards Isaac, with 3 Attack FlyAttack Flies circling around it. Coughs up additional Attack Flies and releases gas to launch the Attack Flies outwards.
Poot Mine
Poot Mine
(in Repentance)
875.0 Creates a gas cloud and propels itself away from Isaac when it gets hit non-consecutively. Explodes on death, detonating all the gas clouds it created.
Bombgagger
Bombgagger
(in Repentance)
844.0 Spits up a Giga BombGiga Bomb and runs away from it.
Flesh Maiden
Flesh Maiden
(in Repentance)
880.0 Vaguely flies towards Isaac in curved swooping motions.
Morningstar
Morningstar
(in Repentance)
863.0 Floats toward Isaac to deal contact damage while Isaac is moving, gaining speed the longer Isaac continues moving. Stops moving when Isaac stops moving.
Needle
Needle
(in Repentance)
881.0 Pops out of the ground and lunges towards Isaac, dealing contact damage.
Pasty
Pasty
(in Repentance)
881.1 Pops out of the ground and lunges toward Isaac, dealing contact damage and firing four shots in the ordinal directions.
Fissure
Fissure
(in Repentance)
815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.
Portal
Portal
(in Afterbirth † and Repentance)
306.0 Spawns various enemies from the current floor until it either vanishes or is killed.
Lil Portal
Lil Portal
(in Repentance)
306.1 Spawns fly and spider enemies until it is destroyed.
Henry
Henry
(in Repentance)
837.0 Flushes itself away shortly after Isaac enters the room.
Stone Grimace
Stone Grimace
42.0 Stationary and invulnerable monster that occasionally fires a blood shot at Isaac. Stops firing when room is cleared.
Vomit Grimace
Vomit Grimace
42.1 Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Triple Grimace
Triple Grimace
(in Repentance)
42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Stone Eye
Stone Eye
201.0 Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Constant Stone Shooter
Constant Stone Shooter
202.0 Stationary and invulnerable monster that continuously fires shots in a single direction.
Cross Stone Shooter
Cross Stone Shooter
(in Afterbirth † and Repentance)
202.10 Stationary and invulnerable monster that continuously fires shots in four directions, alternating between cardinal and ordinal.
Brimstone Head
Brimstone Head
203.0 Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Gaping Maw
Gaping Maw
235.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Broken Gaping Maw
Broken Gaping Maw
236.0 Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles. Alternates between active and inactive every couple of seconds. Has a stronger attraction power than a regular Gaping Maw.
Quake Grimace
Quake Grimace
(in Repentance)
804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace
(in Repentance)
809.0 Stationary and invulnerable monster that keeps a single Throwable BombThrowable Bomb spawned.
Peep Eye
Peep Eye
68.1 Invulnerable enemy that floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. Spawned by Peep as apart of his fight.
Bloat Eye
Bloat Eye
68.11 Invulnerable enemy that floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. Spawned by The Bloat as apart of his fight.
Mockulus
Mockulus
(in Repentance)
864.0 Invulnerable enemy that rapidly floats diagonally over obstacles and bounces off of walls, blocking tears and dealing contact damage. They can only move while Isaac is shooting.
Poky
Poky
44.0 Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Slide
Slide
44.1 Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Wall Hugger
Wall Hugger
218.0 Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Grudge
Grudge
(in Repentance)
877.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Ball and Chain
Ball and Chain
(in Repentance)
893.0 Spike balls that rotate at the end of a chain attached to an obstacle. If the obstacle is destroyed, the ball will fly free around the room for a while.
Spikeball
Spikeball
(in Repentance)
852.0 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Singe's Ball
Singe's Ball
(in Repentance)
915.1 Spawned exclusively as apart Singe's boss fight and used in his attacks. They can be pushed around and launched with explosions.
Pitfall
Pitfall
(except in Rebirth)
291.0 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Suction Pitfall
Suction Pitfall
(except in Rebirth)
291.1 Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall
(except in Rebirth)
291.2 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Death Scythe
Death Scythe
66.10 Stays stationary for a few seconds, then homes in on Isaac.
Ultra Death Scythe
Ultra Death Scythe
(in Repentance)
951.41 Stays stationary for a moment, then travels in straight lines towards Ultra Death.
Corn Mine
Corn Mine
(except in Rebirth)
295.0 Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Siren Minion
Siren Minion
(in Repentance)
3.220 Spawned in automatically charmed by Boss The Siren ingameThe Siren. Orbits the boss and fires projectiles towards Isaac.
Siren Helper
Siren Helper
(in Repentance)
966.0 Spawned in by Boss The Siren ingameThe Siren and takes the form and control of all of her charmed familiars.
Dark Ball
Dark Ball
(except in Rebirth)
404.1 Floats towards Isaac, doing contact damage.
Purple Ball
Purple Ball
(in Afterbirth † and Repentance)
409.1 Floats towards Isaac, doing contact damage.
Visage Plasma
Visage Plasma
(in Repentance)
903.20 Floats in diagonal directions, doing contact damage. Spawned by The Visage and used in its phase 3 attacks.
Ultra Pestilence Fly Ball
Ultra Pestilence Fly Ball
(in Repentance)
951.23 Floats towards Isaac, doing contact damage and spawning Ultra Pestilence Flies upon taking damage.
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner)
(except in Rebirth)
293.0 Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key)
(except in Rebirth)
293.1 Spins on itself and opens a golden door around the room if not destroyed, spawning hordes of Greed Gapers.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb)
(except in Rebirth)
293.2 Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart)
(except in Rebirth)
293.3 Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Dummy
Dummy
(in Repentance)
964.0 Only encounterable through Debug Console, it is immobile, harmless, and used to track Isaac's damage.

Champions[ | ]

See the champions page.

Monster Replacements[ | ]

Some monsters have a chance to be replaced with other monsters when they spawn, (in Afterbirth † and Repentance) but only at room entry. (except in Rebirth) Some replacements only occur on certain floors.

(Disclaimer: Chances are approximate!)

Rebirth[ | ]

Base Monster Replacement Chance
Mulligan Mulligoon 10%
Mulligan Mulliboom 1%
Mulligoon
Hopper Trite 6%
Stone Grimace Vomit Grimace 6%
Dople Evil Twin (except in Repentance) 5%
Eye Bloodshot Eye 5%
Leech Kamikaze Leech 5%
Leech Holy Leech 1%
Kamikaze Leech
Maw Red Maw 10%
Maw Psychic Maw 1%
Red Maw
Host Red Host 10%
Vis Double Vis 6% ((in Repentance)UteroUtero only)
Vis Chubber 1%
Double Vis
Boom Fly Red Boom Fly 10% ((in Repentance) Not in Chapter 1)
Pooter Fat Fly 10%
Knight Selfless Knight 5%
Clotty I.Blob 1%
Clot
MemBrain Mama Guts 6%
Globin Gazing Globin 10%
Baby Angelic Baby 6%
Boil Gut 6%
Boil Sack 1%
Gut
Walking Boil Walking Gut 6%
Walking Boil Walking Sack 1%
Walking Gut
Sucker Spit 6%
Poky Slide (except in Repentance) 6%

(except in Rebirth) Afterbirth[ | ]

Base Monster Replacement Chance Notes
Frowning Gaper Flaming Gaper 60% Exclusive to Burning BasementBurning Basement
Gaper
Fatty Flaming Fatty 60% Exclusive to Burning BasementBurning Basement
Only a single Burning Basement room contains a Pale Fatty, making it a very unusual replacement to witness.
Pale Fatty
Hopper Flaming Hopper 60% Exclusive to Burning BasementBurning Basement
Trite (except in Repentance) 60%
Hive Drowned Hive 50% Exclusive to Flooded CavesFlooded Caves
Charger Drowned Charger 50% Exclusive to Flooded CavesFlooded Caves
Maggot (except in Repentance) 50%
Spitty
Boom Fly Drowned Boom Fly 50% Exclusive to Flooded CavesFlooded Caves
Red Boom Fly
Squirt Dank Squirt 50% Exclusive to Dank DepthsDank Depths
Death's Head Dank Death's Head 50% Exclusive to Dank DepthsDank Depths
Globin Dank Globin 50% Exclusive to Dank DepthsDank Depths
Gazing Globin
Guts Scarred Guts 50% Exclusive to Scarred WombScarred Womb
Para-Bite Scarred Para-Bite 50% Exclusive to Scarred WombScarred Womb
Vis Scarred Double Vis 50% Exclusive to Scarred WombScarred Womb
Double Vis

(in Afterbirth † and Repentance) Afterbirth+[ | ]

Base Monster Replacement Chance Notes
Keeper Blister (except in Repentance) 10%
Ticking Spider (except in Repentance) 20%
Host Mushroom (Enemy) 20% (in Repentance) Exclusive to Chapter 2
Red Host
Hopper Ministro (except in Repentance) 20%
Trite
Nerve Ending Nerve Ending 2 20%
Brain Poison Mind (except in Repentance) 20%
Pale Fatty Stoney 10%
Wall Creep The Thing (except in Repentance) 20%
Blind Creep
Rage Creep
Mr Maw Mr. Red Maw 20%
Skinny Crispy 40% Exclusive to Burning BasementBurning Basement
Rottys do not appear in any Burning Basement room layouts, but can still be replaced regardless.
Rotty
Dank Charger Drowned Charger 50% Exclusive to Flooded CavesFlooded Caves
Dank Chargers do not appear in any Flooded Caves room layouts, but can still be replaced regardless.
Stoney Cross Stoney 20% Exclusive to Aprils Fool challenge

(in Repentance) Repentance[ | ]

Base Monster Replacement Chance
Horf Sub Horf Unknown
Knight Loose Knight Unknown

Bugs[ | ]

Bug Bug! (in Repentance) PS4 Some Champion enemies that turn into another enemy when killed (Gurgle turning into Splasher for instance) will become invisible.


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