Mom's Box is an activated item added in The Binding of Isaac: Afterbirth.
Effects[ | ]
- Increases luck by 1 and doubles the effects of certain trinkets while held. When used, drops a random trinket on the ground.
This item belongs to the Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.
This item belongs to the 
Notes[ | ]
- Most trinkets are not affected. Of the 188 trinkets in Repentance, only 72 have a doubled effect.
- This effect stacks additively with Golden Trinkets; holding one with Mom's Box will cause applicable trinkets to have triple the regular effect.
- Holding a second Mom's Box by using Schoolbag only increases luck, the effects of trinkets are not affected further.
Synergies[ | ]
- Book of Virtues: Spawns a normal wisp with no unique effect.
- Gulp! Pill / Marbles / Smelter: Trinket effects are still doubled when permanently applied to Isaac.
- Broken Remote: Triggers the Teleport 2.0 effect whenever an activated item is used.
- Crystal Key: Increases the chance of red rooms spawning.
- NO!: Prevents items with quality 0 from appearing.
- Rosary Bead: Adds 4 Rosaries to all item pools. Upon picking up a Rosary, the effect will end.
- Tick: Boss' health will be reduced by 30%. Having the Tick also be golden does not further decrease boss' health.
- Hook Worm / Ring Worm / Wiggle Worm: In addition to the further stats increase, they have an increased effect on your tear trajectory.
Interactions[ | ]
- Mother's Kiss: Grants double the heart containers but only one of them is filled.
- Void: Passive effects of Mom's Box are lost if absorbed.
No Effect[ | ]
These trinkets are not affected by Mom's Box.
- 'M
- ???'s Soul
- AAA Battery
- Ace of Spades
- Adoption Papers
- Apple of Sodom
- Baby-Bender
- Bag Lunch
- Bat Wing
- Beth's Essence
- Black Tooth
- Blessed Penny
- Blister
- Bloody Crown
- Bloody Penny
- Blue Key
- Bob's Bladder
- Brain Worm
- Broken Ankh
- Broken Magnet
- Broken Padlock
- Broken Remote
- Burnt Penny
- Butter!
- Cain's Eye
- Callus
- Cartridge
- Charged Penny
- Chewed Pen
- Child's Heart
- Child Leash
- Counterfeit Penny
- Cracked Dice
- Crow Heart
- Cursed Penny
- Cursed Skull
- Daemon's Tail
- Devil's Crown
- Dim Bulb
- Door Stop
- Duct Tape
- Endless Nameless
- Equality!
- Eve's Bird Foot
- Expansion Pack
- Extension Cord
- Faded Polaroid
- Filigree Feather
- Finger Bone
- Fish Head
- Fish Tail
- Flat File
- Flat Penny
- Flat Worm
- Forgotten Lullaby
- Found Soul
- Fragmented Card
- Friendship Necklace
- Gigante Bean
- Gilded Key
- Hairpin
- Holy Crown
- Ice Cube
- Isaac's Head
- Jawbreaker
- Judas' Tongue
- Keeper's Bargain
- Kid's Drawing
- The Left Hand
- Liberty Cap
- Locust of Conquest
- Locust of Death
- Locust of Famine
- Locust of Pestilence
- Locust of War
- Lost Cork
- Louse
- Lucky Rock
- Match Stick
- Meconium
- A Missing Page
- Missing Poster
- Mom's Locket
- Mom's Toenail
- Monkey Paw
- Myosotis
- Mysterious Candy
- Mysterious Paper
- Nose Goblin
- Nuh Uh!
- Number Magnet
- Panic Button
- Paper Clip
- Pay to Win
- Pinky Eye
- Poker Chip
- Pulse Worm
- Rainbow Worm
- RC Remote
- Red Patch
- Rib of Greed
- Ring Worm
- Rosary Bead
- Rotten Penny
- Rusted Key
- Safety Cap
- Safety Scissors
- Samson's Lock
- Shiny Rock
- Short Fuse
- Sigil of Baphomet
- Silver Dollar
- Stem Cell
- Store Credit
- Store Key
- Strange Key
- Super Ball
- Super Magnet
- Telescope Lens
- Temporary Tattoo
- Tonsil
- Torn Card
- Torn Pocket
- Umbilical Cord
- Vibrant Bulb
- Walnut
- Wicked Crown
- Wiggle Worm
- Wish Bone
- Wooden Cross
- Your Soul
Unlockable Achievements[ | ]
- Mom's Contact - Obtain three Yes Mother? items in one run.
Trivia[ | ]
- The item description possibly is a reference to the film Seven (1995) where the climax of the film involves the protagonist asking the question over and over again "What's in the box?".
- The item strongly resembles the chest found in Mom's room in Home.
- This item is used in Pica Run (challenge #41).
 Trinket Modifiers
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| Items |
| Pills |
 The Binding of Isaac: Rebirth
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