Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Mom's Box is an activated item added in The Binding of Isaac: Afterbirth.


  • Increases luck by 1 and doubles the effects of trinkets while held. When used, drops a random trinket on the ground.
  • Added in Repentance This item belongs to the Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.


  • Added in Repentance About 68% of all trinkets (129 out of the 188 trinkets in Repentance) are not doubled by this effect or are not applicable.
  • Added in Repentance This effect stacks additively with Golden Trinket Golden Trinkets; holding one with Mom's Box will cause applicable trinkets to have triple the regular effect.


  • Added in RepentanceBook of Virtues Book of Virtues: Spawns a normal wisp with no unique effect.
  • Added in Afterbirth † Gulp! Pill / Marbles Marbles / Smelter Smelter: Trinket effects are still doubled if they are converted into items.
  • NO! NO!: Prevents items with quality 0 from appearing.


  • Added in Afterbirth †Void Void: Passive effects of Mom's Box are lost if absorbed.

No Effect[]

These trinkets are not affected by Mom's Box.

In-game Footage[]

Unlockable Achievements[]


  • The item description possibly is a reference to the film Seven (1995) where the climax of the film involves the protagonist asking the question over and over again "What's in the box?".
  • Added in Repentance The item strongly resembles the chest found in Mom's room in Home Home.
  • Added in Repentance This item is used in Added in Repentance Pica Run (challenge #41).