Binding of Isaac: Rebirth Wiki

Mom's Bottle of Pills is an activated item.


  • On use, gives Isaac a random pill.
  • Added in Afterbirth This item belongs to the Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.


  • Added in RepentanceBook of Virtues Book of Virtues: Spawns wisps in the inner ring, looking like pills. The wisps spawn pills when destroyed. The wisps come in random colors (Blue, Red, White, Pink, Gray, Light Blue, and Yellow). Each color may fire tears that confuse, poison, petrify, burn, or spawn troll bombs. Each tear effect is assigned to one color of pill wisp based on the current seed. The only color pill wisp without a tear effect also spawns a hostile Spider when destroyed. For the troll bomb effect, the pill itself spawns the troll bomb instead of the tear, and the chance for it to do so is independent of whether or not its tears hit anything.


In-game footage[]




PC KDT4 1YTG (Treasure Room Treasure Room adjacent to spawn)

PC KFSX 99PF (Treasure Room Treasure Room adjacent to spawn)

PC Added in Repentance HR7P W9AQ (Treasure Room Treasure Room adjacent to spawn)