Binding of Isaac: Rebirth Wiki

Missing No. is an unlockable passive item.

Effects[ | ]

Notes[ | ]

  • See Collectible D4 iconD4 for more details of the rerolling process.
  • Due to losing all items every level, it is beneficial to try to gain permanent stat boosts if possible. These include using pills when equipped with Collectible PHD iconPHD or Collectible Virgo iconVirgo, sacrificing health with (in Afterbirth † and Repentance)Collectible Potato Peeler iconPotato Peeler to gain damage or (in Afterbirth † and Repentance)Collectible Brittle Bones iconBrittle Bones to gain tears, or using up Collectible Judas' Shadow iconJudas' Shadow.
  • Like other full-reroll effects, Missing No. has a small chance to not reroll every item.
  • (except in Repentance) Can cause transformations.
    • (in Repentance) Transformations are lost when rerolling out of the items that caused them.
  • Missing No. cannot be re-rolled or removed by most means after being picked up, including Collectible D4 iconD4, (in Afterbirth † and Repentance)Collectible Clicker iconClicker, (in Repentance)XVII - The Stars?XVII - The Stars?, or taking damage as Character Tainted Eden iconTainted Eden.
  • (except in Repentance) This item can be used to gain more health if desperately needed, as the randomization does often include items that grant you various types of hearts.
  • (except in Repentance) If the player has already obtained a large number of items (such as during a run where they have gained infinite money in greed mode), it is highly recommended to avoid this item, as it will almost always end up rerolling all the items the player has thus far collected into Collectible Breakfast iconBreakfast.

Synergies[ | ]

  • (in Afterbirth † and Repentance)Butter!Butter! / (in Repentance)Collectible Genesis iconGenesis: Provide the only available methods for getting rid of Missing No.
  • (except in Rebirth)Collectible Glowing Hourglass iconGlowing Hourglass: Using Glowing Hourglass to go back to the previous floor will keep the rerolled items, which will allow to reroll them again.

Interactions[ | ]

  • (in Repentance)Collectible The Stairway iconThe Stairway: When getting the Stairway at the start of a floor, the ladder doesn't spawn. It will spawn at the start of the next floor even if rerolled.

In-game footage[ | ]

Trivia[ | ]

  • This item is a reference to the infamous MissingNo. glitch occurring in the first-generation Pokémon games. The glitch would often corrupt save files, and therefore randomize various parts of the game as it would use the incomplete index values attributed to entities not included in the final release of the game. Isaac's appearance when affected by Missing No. is based on this glitch which could cause the player's sprite to become scrambled.
  • The item also resembles the painting "Composition II with Red, Blue, and Yellow" by Dutch painter Piet Mondrian.
  • The background color for the Missing No. achievement has the same color as all the challenge unlocks. This implies that Missing No. was originally intended to be unlocked via a challenge. (Or, perhaps, it was intended to be looked at as an error.)
    • The background color for the Suicide King Suicide King achievement has the same color as all the boss rush unlocks. This implies that potentially Character Lazarus iconLazarus would have unlocked Suicide KingSuicide King for completing the Boss RushBoss Rush and Suicide King (challenge #7) would have unlocked Missing No.

Bugs[ | ]

Bug Bug! (in Repentance) Rerolling into Collectible PHD iconPHD from it will not reveal newly acquired pills.