Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Metronome is an unlockable activated item added in Afterbirth †.


  • Grants a random item's effect for the current room.


  • Beware using this as The Lost The Lost, as it can trigger self-harm items and kill him.
  • Using this item multiple times in the same room will replace the previous item with a new one.
  • Metronome cannot grant the effects of itself, Glowing Hour Glass Glowing Hour Glass, or Plan C Plan C.
  • Keep in mind that you can trigger items you haven't unlocked yet, which means you could trigger the effect of items like Added in RepentanceDeath Certificate Death Certificate without having to go through the trouble of unlocking them.
  • If Metronome triggers the effect of Added in RepentanceGenesis Genesis, it will disappear from the active slot, just as with the real item.


  • Blanket Blanket / Holy Card Holy Card / Holy Mantle Holy Mantle / Wooden Cross Wooden Cross: if Metronome is used while the shield is active, any stat changes or familiars/orbitals generated from Metronome will persist between rooms until Metronome is used again or replaced with another active item. Items that modify your stats and have other additional effects will keep the stats but the effect will be gone after leaving the room. For example, the tears down applied from The Inner Eye The Inner Eye will persist between rooms, but Isaac will not shoot three tears at once.
  • Added in RepentanceBook of Virtues Book of Virtues: The wisp spawned will be based on the item it mimicked.
  • Car Battery Car Battery: Metronome is activated twice at once as expected, but the item chosen for the first activation is shown raised above Isaac's head, instead of the second one that actually remains active.

Specific Item Effects[]

  • Certain items used by Metronome have permanent, limited/unusual, or no effect. It is not clear what is intended and what is a bug.
  • Permanent effects include:
    • Health, coins, bombs, or keys that are granted to Isaac directly will persist.
    • Clicker Clicker will permanently remove the latest item and change character.
    • Cube of Meat Cube of Meat granted by Potato Peeler Potato Peeler will persist.
    • D8 D8's rerolled stat multipliers will persist, D4 D4 or D100 D100 will reroll all items permanently and D Infinity D Infinity mimicking any of the previous also has the same effects.
    • Added in RepentanceDamocles Damocles will permanently grant the passive version of Damocles.
    • Dataminer Dataminer's stat changes will persist.
    • Forget Me Now Forget Me Now will restart the level.
    • Added in RepentanceMagic Skin Magic Skin will give Isaac a broken heart, spawn an item, and count as an activation of Magic Skin, causing future items to have a chance of being replaced by Magic Skin.
    • Added in RepentanceR Key R Key will restart the run, retaining all items.
    • Void Void absorbing passives and granting stats will persist.
  • Limited and unusual effects include:
    • Items do not spawn pickups and consumables that they might when picked up normally.
    • Items that adjust Isaac's size will not do so.
    • 1up! 1up! and Guppy's Collar Guppy's Collar give no indication of extra lives, but will still work if you die in the room.
    • Abaddon Abaddon will not remove red hearts or grant black hearts.
    • Belly Button Belly Button and Mom's Purse Mom's Purse allow picking up two trinkets in the room, but if another one is picked up outside, one trinket disappears completely along with the extra slot.
    • Black Candle Black Candle only adds a black heart and does not remove curses.
    • Brittle Bones Brittle Bones and Divorce Papers Divorce Papers do not grant bone hearts. Brittle Bones can still be used to gain permanent tears ups if bone hearts are available.
    • Crown of Light Crown of Light only adds soul hearts, no damage multiplier.
    • Dead Cat Dead Cat will only restore one red heart without setting heart containers to 1. It also gives no extra lives.
    • Removed in RepentanceDeep Pockets Deep Pockets, Little Baggy Little Baggy, Polydactyly Polydactyly, and Starter Deck Starter Deck allow picking up two consumables while in the room and kept outside, but using them will lose the extra slot.
    • Eden's Blessing Eden's Blessing will not grant an extra item for the next run.
    • Fate Fate only grants flight, no eternal heart.
    • PHD PHD will not identify pills, but they are still guaranteed to not be negative.
    • Schoolbag Schoolbag allows picking up two activated items while in the room and they can be kept even outside, but the extra slot and one of the items is lost if another activated item is picked up.
    • Added in RepentanceMega Mush Mega Mush stats increases and Isaac's appearance revert on changing rooms, but Isaac retains the shadow of his large size, the ability to crush rocks, and invulnerability until the 30 seconds are up.
  • The following items remain active until the Metronome is used again or replaced with another active item:
  • The following items have no effect:

In-game Footage[]


  • The name, pickup quote, and effect of this item are a reference to the move 'Metronome' from the Pokémon franchise.
  • This item works similarly to the item Dead Sea Scrolls Dead Sea Scrolls.


Bug Bug! PC It is possible for this item to use an item that can teleport one to the I AM ERROR room. During the Mother Boss fight, this can happen. Using the trapdoor causes the game to crash.
Bug Bug! PC It is possible for this item to give an indefinite Breath of Life Breath of Life effect that persists throughout rooms, eventually killing the player.
Bug Bug! PC If Added in RepentanceUrn of Souls Urn of Souls is activated through Metronome, it won't shoot fire and Isaac could get stuck with the urn in his hands unable to shoot tears. You can fix this by exiting and continuing the run, restarting the room without the urn and without Metronome charges.
Bug Bug! PC Using Metronome in the Cantripped! challenge can cause the game to crash.