Mega Blast

Mega Blast is a secret unlockable activated item added in The Binding of Isaac: Afterbirth.

Effects[]

Picking up a Little Battery with this item will not fully charge it. Instead, it will add 3 to its charge, meaning that 4 batteries are required to fully recharge the item.
- A Charged Key will only add 3 charges as well.
  - Little Batteries and Charged Keys add 6 charges instead of 3.
- Picking up a Mega Battery will fully charge it twice.
Using a 48 Hour Energy pill with this item will fully charge it.
Mega Blast has an 80% decreased item pool weight, making it less likely to appear than other collectibles.
To unlock Mega Blast, Mega Satan must be defeated with all 13 characters.
- Requires defeating Mega Satan as all 15 characters (Now including Apollyon and The Forgotten).
  - Requires defeating Mega Satan as all 17 non-tainted characters. (Now including Bethany and Jacob and Esau)
It is not recommended to use Mega Blast in fight with The Beast, because its beam forces you into obstacles on the level.

All synergies and interactions pertaining to Brimstone pertain to Mega Blast, with the following exceptions and additions:

4.5 Volt: Item will gain charges for dealing damage, which is especially effective when fighting bosses with large health pool.

Schoolbag: Beam will continue to fire when switching to another active item. Other active items can be used while the beam is firing.

Angelic Prism: The beam does not split.
Anti-Gravity: No effect.
Book of Virtues: Spawns red wisps on the middle ring that utilize a miniature Brimstone as their weapon, which requires charging and releasing as usual. Lasers can hit up to 8 times for a total of 20 damage. If Mega Blast is being used, the wisps will continuously fire their laser outward rather than in the direction Mega Blast is firing.
Car Battery: No effect.
Hairpin / Sol: Only grants 3 charges.
Incubus: Familiar fires normal tears while Mega Blast is in use.

Mega Blast's collectible sprite is called 'Mega Satan's Breath' in the game files, which may be its initial name.

PC WCB1 YZ39 (First floor Devil Room)

PC TQWA 6TQD (Curse Room adjacent to spawn, chest teleports to Devil Room)

PC 3KY4 LSVL (Second floor Devil Room)

PC RZL2 6MQ0 (Starting item as Eden, and will also start with Godhead)

PC S3VX RPWZ (Starting item as Eden)

PS4 XGYR 11TV (Starting item as Eden)

PC L6B9 ZZ22 (Starting item as Eden)

PC NZ7T 4RAJ (Starting item as Eden)

PC W3BZ BBB2 (Starting item as Eden)

PC PGH7 BMRT (Starting item as Eden)

Switch PLXX XCLR (Starting item as Eden)

Bug!	If the player continues a run that was exited while Mega Blast was active, Isaac will retain the costume and animation of Mega Blast until the item is used again, but no beam will appear.

Bug!	If the player uses Glowing Hour Glass while in the room that they used Mega Blast, then the Mega Blast attack will still function, but the animation will be removed, and you reobtain full charge for Mega Blast.