This item's effect will not fully activate if picked up by Lilith; its stat ups will still apply to her Incubus familiar, but the ring will not appear unless she also has the Ludovico Technique.
This item will still work while playing as a blindfolded character.
The ring will apply any tear status effects such as poison if Isaac has them.
Guppy: Damaging enemies with Maw of the Void allows flies to spawn from the Guppy transformation. Flies are spawned at a rate of approximately one fly per tick of damage for each enemy it hits. This causes a lot of flies to spawn very quickly. The spawned flies will also move to attack the nearest enemy immediately.
Marked: Crosshair must be moved for 4 seconds before the ring activates.
While firing, the ring charges automatically and activates immediately upon full charge.
Soy Milk: No effect on charge time but massively reduces damage.
Maw of the Void has a unique charge bar, filling with red instead of the usual green, as well as having a small swirl reminiscent of its shape in the middle of it.
When combined with Chocolate Milk, Cursed Eye, Monstro's Lung or Tech X, releasing a Maw of the Void attack may prevent a charged shot from firing at the same time as expected. The charged shot is delayed by about ~0.5 seconds. Holding a full charge for a longer time makes the delay more likely to happen.