Binding of Isaac: Rebirth Wiki
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(in Afterbirth † and Repentance)

Mama Mega! is an activated item added in The Binding of Isaac: Afterbirth †.

Effects[ | ]

  • Destroys all obstacles in the current room and deals 200 damage to every enemy (including Bosses). This effect also applies to every room for the remainder of the floor.
  • Opens all Secret RoomSecret Room and Super Secret RoomSuper Secret Room doors on the current floor.
  • Mama Mega! opens the paths to Boss RushBoss Rush and the ?????? even after the time limits expire.

Notes[ | ]

  • While Mama Mega! opens the paths to Boss RushBoss Rush and the ?????? after the time limits expire, there are still some things to be aware of:
    • The Boss does not need to be defeated before entering these doors.
    • It will also open the Boss Rush / ?????? entrance room door if it is activated after Boss Mom ingameMom or Boss Mom's Heart ingameMom's Heart/ Boss It Lives ingameIt Lives has already been defeated.
    • Leaving the Boss RoomBoss Room (via teleport or entering a Devil RoomDevil Room/Angel RoomAngel Room) will close the doors.
    • Leaving the Boss RushBoss Rush room or ?????? entrance room will also close the doors.
    • Does not open the Boss Rush door from the inside.
    • (in Repentance) Does not open a path to ?????? if used in the room on the other side of the flesh door in MausoleumMausoleum / GehennaGehenna II.
  • Entering a room with an angel statue while the effect is active automatically initiates a fight with an Angel.
  • Does not kill enemies that are immune to damage while entering the room, such as Lil' Haunts.
  • If used before the Boss Ultra Greed ingameUltra Greed fight begins, it will deal no damage to Ultra Greed, as he is invulnerable for the first few seconds upon first entering his room. However, it will still break obstacles as usual.
  • When used in Greed mode, it will only activate once for the main room (as opposed to once per wave, in a similar fashion to a standard run). Therefore, its damage potential is maximized if used after all the monster waves have spawned for the current floor.
  • Does not open the door to Mega Satan Head ingameMega Satan in Dark RoomDark Room or ChestChest, nor does it open (in Repentance) the flesh door at the end of MausoleumMausoleum / GehennaGehenna II..
  • (in Repentance) If used in DownpourDownpour / DrossDross II, the entrance to the Mirrored World will be destroyed, making it inaccessible.
    • If used in the Mirrored World, it will destroy the exit, which, on top of making it impossible to leave, will then cause Isaac to take damage and die.
    • This can be avoided by entering and immediately leaving the room before the shockwave reaches the mirror.
  • (in Repentance) Only works on a single floor of the Ascent

Synergies[ | ]

  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Summons 8 wisps in the middle ring on use. The wisps summon Golden Troll BombGolden Troll Bombs when destroyed.
    • Mama Mega! + Safety ScissorsSafety Scissors: Allows for infinite uses of Mama Mega! after finding a Golden Bomb or ? Card? Card, as the extinguished Golden Troll Bombs will turn into Golden Bombs.
    • Safety ScissorsSafety Scissors: If isaac still has Mama Mega after spawning the wisps, the golden troll bombs spawned can be used to endlessly re-use it.
      • (in Repentance)Collectible Bag of Crafting iconBag of Crafting: The infinite golden bombs created can be used to easily craft high quality items.
  • (in Repentance)Broken PadlockBroken Padlock: Mama Mega!'s blast will also open locks.
  • Golden BombGolden Bomb: While holding a golden bomb, Mama Mega! can be used once on that floor without consuming it but will remove the golden bomb from Isaac's consumables (using it a second time consumes it as normal). It may be used again for free on another floor if yet another golden bomb is collected, and so on. (in Repentance) Mama Mega! also receives an unique golden sprite in the HUD.

Interactions[ | ]

  • Collectible Car Battery iconCar Battery: No effect.
  • (except in Repentance)Collectible Void iconVoid: Can't be consumed by Void.
    • (in Repentance) If consumed by Void, the Mama Mega! effect will be activated once only, the next time Void is activated.
  • (except in Repentance)? Card? Card: Mama Mega! will be activated and consumed.
    • (in Repentance) Mama Mega!'s effect can be activated through the card without consuming the actual item.

In-game Footage[ | ]

Gallery[ | ]

Trivia[ | ]

  • (in Repentance) The visual effect has been changed from a simple screen flash and shake to a massive shockwave on entering each room.
  • (in Repentance) Mama Mega!'s effect is one of the only two ways a Bomb BumBomb Bum can be destroyed.
  • Mama Mega! may be a reference to the GBU-43, known colliqually as the mother of all bombs due to its massive payload.


Bugs[ | ]

Bug Bug! (in Repentance) Mama Mega! can break the door to the Collectible Knife Piece 2 iconKnife Piece 2 room. If Isaac leaves this room before the intro animation of Mother's Shadow finishes and then enters it again, another Mother's Shadow will be generated.
Bug Bug! XboxOne PS4 Mama Mega! cannot be used to open the doors to Boss RushBoss Rush / ??????.


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