Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Mama Mega! is an activated item added in The Binding of Isaac: Afterbirth †.



  • Mama Mega! opens the paths to Boss Rush and the ??? ??? in the boss rooms even after the time limits expire.
    • After the bomb goes off, you may simply walk through the Boss Rush / Blue Womb door without defeating the boss first.
    • It will also open the Boss Rush / Blue Womb door if it is activated after Mom or Mom's Heart/It Lives have already been defeated.
    • Leaving the boss room (via a warp card or devil/angel deal) will close the doors.
    • Leaving the boss rush room or Blue Womb entrance room will also close the doors.
    • With 15►Schoolbag Schoolbag and 15►Diplopia Diplopia, Mama Mega! can be doubled to get into both Boss Rush and the ??? ??? in the same run after the time limits expire.
    • Added in Repentance Does not open a path to ??? ??? if used in the room on the other side of the flesh door in Mausoleum Mausoleum/Gehenna Gehenna II.
  • Removed in Repentance Like all single-use active items, this item cannot be absorbed by 15►Void Void.
    • Added in Repentance It can be absorbed by 15►Void Void, but it can still be used only on one floor.
  • Entering a room with an angel statue while the effect is active automatically initiates a fight with an Angel.
  • Does not kill Lil' Haunts and other enemies that are immune to damage while entering the room.
  • If used before the Ultra Greed fight begins, it will deal no damage to Ultra Greed, as he is invulnerable for the first few seconds upon first entering his room. However, it will still break obstacles as usual.
  • When used in Greed mode, it will only activate once for the main room (as opposed to once per wave, in a similar fashion to a standard run). Therefore, its damage potential is maximized if used after all the monster waves have spawned for the current floor.
  • Does not open the door to Mega Satan in Chest Chest or Dark Room Dark Room.
  • Added in Repentance If used in Downpour Downpour/Dross Dross II, the entrance to the Mirrored world will be destroyed, making it inaccessible.
    • If used in the Mirrored world it will destroy the exit, which, on top of making it impossible to leave, will then cause Isaac to take damage and die.
    • This can be avoided by entering and immediately leaving the room before the shockwave reaches the mirror.
  • Added in Repentance Does not open the flesh door at the end of Mausoleum Mausoleum/Gehenna Gehenna II.


  • Added in RepentanceBroken Padlock Broken Padlock: Mama Mega's blast will also open locks.
  • x Gold Bomb: While holding a gold bomb, Mama Mega! can be used once on that level without consuming it. It may be used again for free on another level if another golden bomb is collected.


  • Removed in Repentance? Card ? Card: Mama Mega! will be activated and consumed.
    • Added in Repentance Mama Mega!'s effect can be activated through the card without consuming the actual item.
  • 15►Car Battery Car Battery: No effect.

In-game Footage[]


  • Added in Repentance The visual effect has been changed from a simple screen flash and shake to a massive shockwave on entering each room.
  • Added in Repentance Mama Mega!'s effect is one of the only two ways a Bomb Bum can be destroyed.


Bug Bug! Mama Mega! can break Knife Piece 2's door (locked when you pick up Knife Piece 2, and naturally unlocked until Mother's Shadow appearing animation finishes). If you leave this room before the animation finishes and then enter this room again, another Mother's Shadow will be generated.

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