Leaving the Boss Rush room or ??? entrance room will also close the doors.
Does not open a path to ??? if used in the room on the other side of the flesh door in Mausoleum / Gehenna II.
Entering a room with an angel statue while the effect is active automatically initiates a fight with an Angel.
Does not kill Lil' Haunts and other enemies that are immune to damage while entering the room.
If used before the Ultra Greed fight begins, it will deal no damage to Ultra Greed, as he is invulnerable for the first few seconds upon first entering his room. However, it will still break obstacles as usual.
When used in Greed mode, it will only activate once for the main room (as opposed to once per wave, in a similar fashion to a standard run). Therefore, its damage potential is maximized if used after all the monster waves have spawned for the current floor.
Golden Bomb: While holding a golden bomb, Mama Mega! can be used once on that floor without consuming it (using it a second time consumes it as normal). It may be used again for free on another floor if yet another golden bomb is collected, and so on.
If consumed by Void, the Mama Mega! effect will be activated once only, the next time Void is activated.
? Card: Mama Mega! will be activated and consumed.
Mama Mega!'s effect can be activated through the card without consuming the actual item.
The visual effect has been changed from a simple screen flash and shake to a massive shockwave on entering each room.
Mama Mega!'s effect is one of the only two ways a Bomb Bum can be destroyed.
Mama Mega! can break the door to the Knife Piece 2 room. If Isaac leaves this room before the intro animation of Mother's Shadow finishes and then enters it again, another Mother's Shadow will be generated.
XboxOne Mama Mega! cannot be used to open the doors to Boss Rush / ???.