Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Mama Mega! is an activated item added in The Binding of Isaac: Afterbirth †.


  • Destroys all obstacles in the current room and deals 200 damage to every enemy (including Bosses). This effect also applies to every room for the remainder of the floor.
  • Opens all Secret Room Secret Room and Super Secret Room Super Secret Room doors on the current floor.


  • Mama Mega! opens the paths to Boss Rush Boss Rush and the ??? ??? even after the time limits expire.
    • The Boss does not need to be defeated before entering these doors.
    • It will also open the Boss Rush / ??? ??? entrance room door if it is activated after Mom Mom or Mom's Heart Mom's Heart/ It Lives It Lives has already been defeated.
    • Leaving the Boss Room Boss Room (via teleport or entering a Devil Room Devil Room/Angel Room Angel Room) will close the doors.
    • Leaving the Boss Rush Boss Rush room or ??? ??? entrance room will also close the doors.
    • Added in Repentance Does not open a path to ??? ??? if used in the room on the other side of the flesh door in Mausoleum Mausoleum / Gehenna Gehenna II.
  • Entering a room with an angel statue while the effect is active automatically initiates a fight with an Angel.
  • Does not kill Lil' Haunts and other enemies that are immune to damage while entering the room.
  • If used before the Ultra Greed Ultra Greed fight begins, it will deal no damage to Ultra Greed, as he is invulnerable for the first few seconds upon first entering his room. However, it will still break obstacles as usual.
  • When used in Greed mode, it will only activate once for the main room (as opposed to once per wave, in a similar fashion to a standard run). Therefore, its damage potential is maximized if used after all the monster waves have spawned for the current floor.
  • Does not open the door to Mega Satan Mega Satan in Dark Room Dark Room or Chest Chest.
  • Added in Repentance If used in Downpour Downpour / Dross Dross II, the entrance to the Mirrored World will be destroyed, making it inaccessible.
    • If used in the Mirrored World, it will destroy the exit, which, on top of making it impossible to leave, will then cause Isaac to take damage and die.
    • This can be avoided by entering and immediately leaving the room before the shockwave reaches the mirror.
  • Added in Repentance Does not open the flesh door at the end of Mausoleum Mausoleum / Gehenna Gehenna II.


  • Added in RepentanceBook of Virtues Book of Virtues: Summons 8 wisps in the middle ring on use. The wisps summon Golden Troll Bomb Golden Troll Bombs when destroyed.
  • Added in RepentanceBroken Padlock Broken Padlock: Mama Mega!'s blast will also open locks.
  • Golden Bomb Golden Bomb: While holding a golden bomb, Mama Mega! can be used once on that floor without consuming it but will remove the golden bomb from Isaac's consumables (using it a second time consumes it as normal). It may be used again for free on another floor if yet another golden bomb is collected, and so on. Added in Repentance Mama Mega! also receives an unique golden sprite in the HUD.


  • Car Battery Car Battery: No effect.
  • Removed in RepentanceVoid Void: Can't be consumed by Void.
    • Added in Repentance If consumed by Void, the Mama Mega! effect will be activated once only, the next time Void is activated.
  • Removed in Repentance? Card ? Card: Mama Mega! will be activated and consumed.
    • Added in Repentance Mama Mega!'s effect can be activated through the card without consuming the actual item.

In-game Footage[]



  • Added in Repentance The visual effect has been changed from a simple screen flash and shake to a massive shockwave on entering each room.
  • Added in Repentance Mama Mega!'s effect is one of the only two ways a Bomb Bum.png Bomb Bum can be destroyed.
  • Mama Mega! may be a reference to the GBU-43, known colliqually as the mother of all bombs due to its massive payload.


Bug Bug! Added in Repentance Mama Mega! can break the door to the Knife Piece 2 Knife Piece 2 room. If Isaac leaves this room before the intro animation of Mother's Shadow finishes and then enters it again, another Mother's Shadow will be generated.
Bug Bug! XboxOne Mama Mega! cannot be used to open the doors to Boss Rush Boss Rush / ??? ???.