Binding of Isaac: Rebirth Wiki

(except in Rebirth)

Louse is a trinket added in The Binding of Isaac: Afterbirth.

Effects[ | ]

  • Occasionally spawns a Blue Spider.
    • Effect only occurs when in an uncleared room.
    • After the first spider spawns, there is a 50% chance of one spawning after 30 seconds and a guaranteed spawn a minute later.

Synergies[ | ]

  • (in Repentance)Golden Trinket Golden Trinket / Collectible Mom's Box iconMom's Box / LouseLouse : Each copy of the effect will spawn an additional spider every time one is spawned.

In-game Footage[ | ]

Trivia[ | ]

  • The phrase "Itchy, tasty..." is a reference to the Keeper's Diary from Resident Evil. The Diary describes the slow transformation of a researcher into a zombie as his entries become less and less coherent due to neural decay caused by t-Virus infection. His final entry consists of two words: "Itchy. Tasty.".