Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Louse is a trinket added in The Binding of Isaac: Afterbirth.


  • Occasionally spawns a Blue Spider.
    • Effect only occurs when in an uncleared room.
    • After the first spider spawns, there is a 50% chance of one spawning after 30 seconds and a guaranteed spawn a minute later.


  • This trinket's effect can be increased by Mom's Box Mom's Box, obtaining multiple copies, or by obtaining the Added in RepentanceGolden Trinket Golden Trinket version. More spiders will be spawned when this trinket's effect is triggered.

Ingame Footage[]


  • The phrase "Itchy, tasty..." is a reference to the Keeper's Diary from Resident Evil. The Diary describes the slow transformation of a researcher into a zombie as his entries become less and less coherent due to neural decay caused by t-Virus infection. His final entry consists of two words: "Itchy. Tasty.".