Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Louse is a trinket.


  • Occasionally spawns a Blue Spider.
    • Effect only occurs when in an uncleared room.
    • After the first spider spawns, there is a 50% chance of one spawning after 30 seconds and a guaranteed spawn a minute later.


  • This trinket's effect can be increased by 15►Mom's Box Mom's Box, obtaining multiple copies, or by obtaining the Added in RepentanceGolden Trinket version. More spiders will be spawned when this trinket's effect is triggered.

Ingame Footage[]


  • The phrase "Itchy, tasty..." is a reference to the Keeper's Diary from Resident Evil. The Diary describes the slow transformation of a researcher into a zombie as his entries become less and less coherent due to neural decay caused by t-Virus infection. His final entry consists of two words: "Itchy. Tasty.".

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