Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance
Questionmarkisaac.png For the trinket with a similar name, see Found Soul. For another trinket with a similar name, see Your Soul.

Lost Soul is a passive item added in The Binding of Isaac: Repentance.


  • Gives Isaac a small soul familiar that closely follows behind him. If the soul takes damage, it dies, respawning at the start of the next floor.
  • If the soul survives to the start of the next floor, it spawns one of the following:


  • Floors completed during the Ascent count.
  • It is advised to skip picking up the item until after you clear the floor, in order to guarantee rewards.
  • After the Mother's Shadow chase, the Lost Soul familiar will be revived allowing you to have a second chance at a reward.


  • 15►BFFS! BFFS!: Gives the Lost Soul 15►Holy Mantle Holy Mantle.
  • 15►Forget Me Now Forget Me Now: Restarting a floor triggers the Lost Soul if it is alive.
  • Tainted Isaac Tainted Isaac: Swapping Lost Soul for another item and picking it back up again will cause it to respawn if it died previously.


  • 15►Bursting Sack Bursting Sack Does not provide immunity to contact damage from spiders to the Lost Soul.


Bug Bug! If the Lost Soul is killed before the chasing with Mother's Shadow, it will respawn after you leave the place containing 15►Knife Piece 2 Knife Piece 2 safely.
Bug Bug! When playing as Tainted Lazarus, if Lost Soul is killed, it will respawn on the same floor it died on as soon as Tainted Lazarus flips again.
Bug Bug! Lost Soul can die if it touches projectiles generated by friendly enemies (spawned from Mystery Egg, for example).
Bug Bug! Lost Soul will give rewards when moving from the starting room of a floor to the previous floor with 15►Glowing Hour Glass Glowing Hour Glass twice.

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