Binding of Isaac: Rebirth Wiki

Added in Repentance
Questionmarkisaac.png For the trinket with a similar name, see Found Soul. For another trinket with a similar name, see Your Soul.

Lost Soul is an unlockable passive item added in The Binding of Isaac: Repentance.



  • Floors completed during the Ascent count.
  • Waiting until after the floor is cleared before picking up Lost Soul nearly guarantees a reward payout on the next floor.
  • The ghost can take explosive damage from Isaac, e.g. via placing a Bomb Bomb.
  • If a new floor is entered and Missing No. Missing No. rerolls into this item, it will immediately give a reward.


  • BFFS! BFFS!: Gives Lost Soul a once-per-room shield, similar to Holy Mantle Holy Mantle.
    • If BFFS! is dropped, the shield will still remain active until taking one hit of damage, acting similarly to Holy Card Holy Card.
  • Forget Me Now Forget Me Now: Restarting a floor causes Lost Soul to give a reward if it's alive when used.


In-game footage[]


Bug Bug! If Lost Soul is killed before the segment with Mother's Shadow, it will respawn after Isaac returns to the normal floor.
Bug Bug! Lost Soul can die if it touches projectiles generated by friendly enemies (spawned from Mystery Egg Mystery Egg, for example).
Bug Bug! Swapping Lost Soul for another item as Tainted Isaac Tainted Isaac and picking it back up again will cause it to respawn if it died previously. This can also be accomplished with Butter! Butter!.