Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies, dealing double tear damage for the impact of the Locust and 60 damage for the explosion.
This trinket can be dangerous to hold, as the locust will instantly target the nearest enemy as Isaac enters the room, which can be close enough to catch Isaac in its blast radius.
The explosion takes most bomb effects from items that Isaac has, with some exceptions.
The Locust does not gain additional explosion damage or radius from Mr. Mega.
The explosion damage is halved to 30 by Bomber Boy without additional explosions.
Additional smaller explosions will spawn in a tight + formation.
Before Booster Pack #3, Locust of War was named Locust of Wrath. Unlike other Locusts, the name of Locust of Wrath was from one of seven Deadly Sins instead of four Harbingers.