- 'M
- 120 Volt
- 1up!
- 20/20
- 2Spooky
- 3 Dollar Bill
- 4.5 Volt
- 7 Seals
- 8 Inch Nails
- 9 Volt
- ???'s Only Friend
- ???'s Soul
- ??? (Boss)
- ??? (Bosses)
- ??? (Character)
- ??? (Disambiguation)
- ??? (Floor)
- ? Card
- AAA Battery
- A Bar of Soap
- A Card Against Humanity
- A Dollar
- A Lighter
- A Lump of Coal
- A Missing Page
- A Pony
- A Pound of Flesh
- A Quarter
- A Snack
- A Strange Door
- Abaddon
- Abel
- Abyss
- Ace of Spades
- Achievement Tips
- Achievements
- Acid Baby
- Act of Contrition
- Adoption Papers
- Adrenaline
- Adult
- Akeldama
- Alabaster Box
- All Bosses (Bosses)
- All Mini-Bosses (Bosses)
- Almond Milk
- Alternate Bosses (Bosses)
- Analog Stick
- Anarchist Cookbook
- Ancient Recall
- Anemic
- Angel
- Angel Room
- Angel Room (Greed Mode Item Pool)
- Angel Room (Item Pool)
- Angelic Prism
- Angry Fly
- Anima Sola
- Ankh
- Anti-Gravity
- Apollyon
- Apollyon's Best Friend
- Apple!
- Apple of Sodom
- Aprils Fool
- Aquarius
- Arcade
- Aries
- Ascent
- Ashpit
- Astral Projection
- Athame
- Attributes
- Azazel
- Azazel's Rage
- Azazel's Stump
- BBF
- BFFS!
- BOGO Bombs
- BRAINS!
- Baby
- Baby-Bender
- Baby Long Legs
- Baby Plum
- Baby Shop (Item Pool)
- Backasswards
- Backstabber
- Bag Lunch
- Bag of Crafting
- Ball and Chain
- Ball of Bandages
- Ball of Tar
- Baptism by Fire
- Basement
- Bat Wing
- Batteries
- Battery (Disambiguation)
- Battery Bum (Item Pool)
- Battery Pack
- Bean (Disambiguation)
- Beans!
- Bedroom
- Beelzebub
- Beggar
- Beggar (Item Pool)
- Belly Button
- Belly Jelly
- Berserk!
- Best Bud
- Best Friend
- Bestiary
- Bestiary Repentance
- Beth's Essence
- Beth's Faith
- Bethany
- Betrayal
- Bible (Disambiguation)
- Bible Tract
- Big Chubby
- Big Fan
- Big Horn
- Binding of Isaac: Rebirth Wiki
- Binding of Isaac: Rebirth Wiki/editable
- Binding of Isaac: Rebirth Wiki/ja
- Binding of Isaac: Rebirth Wiki/ko
- Binding of Isaac: Rebirth Wiki/uk
- Binding of Isaac: Rebirth Wiki/zh
- Binge Eater
- Binky
- Bird's Eye
- Bird Cage
- Birthright
- Bishop
- Black Candle
- Black Feather
- Black Hole
- Black Lipstick
- Black Lotus
- Black Market
- Black Powder
- Black Tooth
- Blank Card
- Blank Rune (Achievement)
- Blanket
- Blaster
- Blasting Cap
- Blastocyst
- Blessed Penny
- Blighted Ovum
- Blind Rage
- Blindfolded
- Blister
- Blocks
- Blood (Disambiguation)
- Blood Bag
- Blood Bombs
- Blood Clot
- Blood Oath
- Blood Puppy
- Blood Rights
- Blood of the Martyr
- Bloodshot Eye
- Bloody Crown
- Bloody Gust
- Bloody Lust
- Bloody Mary
- Bloody Penny
- Blue Bomber
- Blue Cap
- Blue Key
- Blue Map
- Bob
- Bob's Bladder
- Bob's Brain
- Bob's Curse
- Bob's Rotten Head
- Bobby-Bomb
- Boil
- Boiled Baby
- Bomb (Disambiguation)
- Bomb Bag
- Bomb Bum (Item Pool)
- Bomber Boy
- Bombgagger
- Bombs
- Bone Spurs
- Bony
- Book (Disambiguation)
- Book of Revelations
- Book of Secrets
- Book of Shadows
- Book of Virtues
- Book of the Dead
- Bookworm
- Boom!
- Boom Fly
- Booster Pack (Item)
- Booster Packs
- Boss (Greed Mode Item Pool)
- Boss (Item Pool)
- Boss Room
- Boss Rush
- Bosses
- Bot Fly
- Box
- Box of Friends
- Box of Spiders
- Bozo
- Brain
- Brain Worm
- Breakfast
- Breaking Run
- Breath of Life
- Brimstone
- Brimstone Bombs
- Brittle Bones
- Broken Ankh
- Broken Glass Cannon
- Broken Glasses
- Broken Magnet
- Broken Modem
- Broken Padlock
- Broken Remote
- Broken Shovel
- Broken Syringe
- Broken Watch
- Brother Bobby
- Brown Cap
- Brown Nugget
- Brownie
- Bucket of Lard
- Buddy in a Box
- Bugs
- Bum Friend
- Bumbino
- Bumbo
- Burning Basement
- Burnt Penny
- Bursting Sack
- Butt Bombs
- Butt Penny
- Butter!
- Butter Bean
- Buttlicker
- Buttons
- C.H.A.D.
- C Section
- Caffeine Pill
- Cain
- Cain's Eye
- Cain's Other Eye
- Callus
- Cambion Conception
- Camo Undies
- Cancer
- Cancer (Trinket)
- Candler
- Candy Heart
- Cantripped!
- Capricorn
- Car Battery
- Card Reading
- Cards and Runes
- Carrion Queen
- Cartridge
- Cat-o-nine-tails
- Cat Got Your Tongue
- Catacombs
- Cathedral
- Caves
- Cellar
- Celtic Cross
- Censer
- Ceremonial Robes
- Challenge Room
- Challenges
- Champion Belt
- Champions
- Chaos
- Chaos Card
- Chapter 1.5 (Bosses)
- Chapter 1 (Bosses)
- Chapter 2.5 (Bosses)
- Chapter 2 (Bosses)
- Chapter 3.5 (Bosses)
- Chapter 3 (Bosses)
- Chapter 4 (Bosses)
- Chapter 5 (Bosses)
- Chapter 6 (Bosses)
- Chapters
- Characters
- Charged Baby
- Charged Penny
- Charger
- Charm of the Vampire
- Charmed Poop
- Chemical Peel
- Chest (Disambiguation)
- Chest (Floor)
- Chests
- Chewed Pen
- Child's Heart
- Child Leash
- Chimera
- Chocolate Milk
- Chub
- Circle of Protection
- Classes
- Clear Rune
- Clicker
- Clog
- Closets
- Clotty
- Clutch
- Co-op
- Cobwebs
- Cod Worm
- Cohort
- Coin (Disambiguation)
- Coins
- Collection Page
- Collection Page (Afterbirth)
- Collection Page (Afterbirth †)
- Collection Page (Rebirth)
- Collection Page (Repentance)
- Colostomia
- Completion Marks
- Compost
- Compound Fracture
- Computer Savvy
- Cone Head
- Conjoined
- Conquest
- Consolation Prize
- Contagion
- Continuum
- Contract From Below
- Converter
- Corn Mine
- Corpse
- Corpse (Bosses)
- Corrupt Data
- Corrupted Data
- Counterfeit Penny
- Coupon