If Lilith dies in Co-Op mode, she won't have the Incubus or the blindfold over her eyes, but her ghost will still be unable to fire tears.
Lilith is very powerful in Greed Mode due to box of friends being able to be used multiple times per room.
Lilith's Incubus familiar copies whatever tears she would fire if she weren't blindfolded. Combined with the Box of Friends, the basic strategy for her is to simply multiply her damage. Powerful tear modifiers such as Polyphemus will become even more deadly if Lilith can create several Incubi.
Mom's Knife gives Incubus a smaller version of the item with the same base range as Isaac; However, Lilith will not get this to use due to her blindfold.
This knife can be used with Incubus to give it contact damage with no danger to Lilith.
With Mom's Knife and Tech X, Incubus can shoot Tech X shots and Mom's Knife incredibly fast for massive damage. Charging doesn't affect Tech X's size or Mom's Knife's throwing distance, making the knife useless in this combo unless used at very short range. This is a very strong combo for Lilith as she already starts with Incubus and can use Box of Friends to multiply her damage.
If Brimstone is taken after Tech X, Incubus will still fire its standard laser rings, not Brimstone rings.
Lilith can use the Epic Fetus while her Incubi still fire what her tears would be without Epic Fetus.
Unless you have a beam weapon (Brimstone/Technology), picking up My Reflection is a bad idea: it will greatly shorten Incubus' range without the possibility to increase it.
Car Battery will double the effect of the item, meaning she'll create 2 copies of each familiar per use.
Charged Baby creates batteries or recharges your item by one bar occasionally, and is also duplicated by the Box of Friends. The more the player creates, the more often they will obtain batteries and charges from the increasing number of charged babies.
Heart Containers, healing items, and Heart-generating items (Charm of the Vampire, Humbling Bundle, etc.) indirectly benefit Lilith since her Cambion Conception gives her additional familiars after taking multiple hits. Use a fireplace or Heart Donation Machine to damage yourself multiple times to speed up the familiar-generating process (preferably after killing the boss to not hurt your Devil/Angel Room spawn chances).
Due to this, during Greed mode, it is most effective to stay within the Arena for every wave in order to maximize the amount of familiars you have upon reaching the boss waves.
4.5 Volt replaces the per-wave charging. With only this, compared to no battery items, starting and ending fully charged, it's typically possible to use Box of Friends once or twice more in a full set of Greed Mode waves.
When shooting, keep in mind that Incubus lingers behind you.
One must take heed in duplicating familiars with the Box of Friends. If the player creates too many (easy to achieve in Greed Mode or Boss Rush), when the player steps into another room, all of their minions, including the originals, will despawn. This can be fixed by quitting and reloading the run.
Cursed Eye ends up being a powerful item due to this, as it causes Incubus to fire three tears per shot with no charging, while Lilith doesn't have to worry about getting teleported by accident as she cannot charge up.
While other activatable items may have some form of use, it is not advised to permanently trade out the Box of Friends. Without it, Lilith loses what is essentially her greatest strength, as Incubus shooting in her place is only a positive with its usage.
Lilith's Incubus is intrinsic to her, the same way Azazel's short Brimstone is. It cannot be removed by effects that reroll items, such as the D4. The Incubus can be found as a separate item, and picking it up will grant Lilith a second Incubus familiar.
Lilith is the Hebrew name for a figure in Jewish mythology, thought to be derived from early class of female demons.
In some cultures, Lilith is the original woman God created before Eve. She refused to become subservient to Adam and left Eden; in others, she is depicted as the bane of humanity when Adam refused her, driving her to curse all of his descendants and targets children under grudge.
Cambion Conception is always listed as one of Lilith's starting items, even if it has not been unlocked.
Lilith, as well as The Lost and Bethany, are the only non-tainted characters whose unlock conditions require a specific character.
Lilith's starting health is listed as "?" on the character selection screen.