Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Lilith is a character added in The Binding of Isaac: Afterbirth. Lilith starts with one red heart container and two Black Heart Black Hearts. Lilith's starting items are the Box of Friends Box of Friends, Incubus Incubus and Cambion Conception Cambion Conception. Lilith is permanently blindfolded, meaning she has no ability to fire tears; she instead deals damage with the Incubus Incubus familiar that follows her.

Lilith is unlocked by completing Greed mode with Azazel Azazel.


  • Lilith's Incubus cannot be rerolled.
    • The Incubus can be found as a separate item, and picking it up will grant Lilith a second Incubus familiar.
  • If Lilith dies in Co-Op mode, she won't have the Incubus or the blindfold over her eyes, but her ghost will still be unable to fire tears.
  • Lilith is very powerful in Greed Mode due to box of friends being able to be used multiple times per room.
  • Lilith's Incubus familiar copies whatever tears she would fire if she weren't blindfolded. Combined with the Box of Friends Box of Friends, the basic strategy for her is to simply multiply her damage. Powerful tear modifiers such as Polyphemus Polyphemus will become even more deadly if Lilith can create several Incubi.
  • Mom's Knife Mom's Knife gives Incubus a smaller version of the item with the same base range as Isaac; However, Lilith will not get this to use due to her blindfold.
    • This knife can be used with Incubus to give it contact damage with no danger to Lilith.
  • With Mom's Knife Mom's Knife and Tech X Tech X, Incubus can shoot Tech X Tech X shots and Mom's Knife Mom's Knife incredibly fast for massive damage. Charging doesn't affect Tech X's size or Mom's Knife's throwing distance, making the knife useless in this combo unless used at very short range. This is a very strong combo for Lilith as she already starts with Incubus Incubus and can use Box of Friends Box of Friends to multiply her damage.
    • Removed in Repentance If Brimstone Brimstone is taken after Tech X Tech X, Incubus will still fire its standard laser rings, not Brimstone rings.
  • Removed in Repentance Lilith can use the Epic Fetus Epic Fetus while her Incubi still fire what her tears would be without Epic Fetus.
  • Unless you have a beam weapon (Brimstone Brimstone/Technology Technology), picking up My Reflection My Reflection is a bad idea: it will greatly shorten Incubus' range without the possibility to increase it.
  • Due to her starter item Box of Friends Box of Friends, she strongly benefits from other familiars and familiar enhancers like BFFS! BFFS!.
  • Battery items are very useful for Lilith so she can continue to use the Box of Friends Box of Friends.
    • 9 Volt 9 Volt will reduce it to a 3-room (Added in Repentance 2-room) charge allowing it to be used more often.
    • Car Battery Car Battery will double the effect of the item, meaning she'll create 2 copies of each familiar per use.
    • Charged Baby Charged Baby creates batteries or recharges your item by one bar occasionally, and is also duplicated by the Box of Friends Box of Friends. The more the player creates, the more often they will obtain batteries and charges from the increasing number of charged babies.
  • Heart Containers, healing items, and Heart-generating items (Charm of the Vampire Charm of the Vampire, Humbling Bundle Humbling Bundle, etc.) indirectly benefit Lilith since her Cambion Conception Cambion Conception gives her additional familiars after taking multiple hits. Use a fireplace or Heart Donation Machine to damage yourself multiple times to speed up the familiar-generating process (preferably after killing the boss to not hurt your Devil/Angel Room spawn chances).
  • Activated Items recharge per-wave in Greed Mode and Boss Rush Boss Rush, allowing Lilith to use the Box of Friends Box of Friends very often. Familiars like The Relic The Relic and Little C.H.A.D. Little C.H.A.D. could give the player an endless amount of health if used correctly.
    • Due to this, during Greed mode, it is most effective to stay within the Arena for every wave in order to maximize the amount of familiars you have upon reaching the boss waves.
    • Added in Repentance4.5 Volt 4.5 Volt replaces the per-wave charging. With only this, compared to no battery items, starting and ending fully charged, it's typically possible to use Box of Friends Box of Friends once or twice more in a full set of Greed Mode waves.
  • When shooting, keep in mind that Incubus Incubus lingers behind you.
  • One must take caution in duplicating familiars with the Box of Friends Box of Friends. If the player creates too many (easy to achieve in Greed Mode or Boss Rush), when the player steps into another room, all of their minions, including the originals, will despawn. This can be fixed by quitting and reloading the run.
  • Since Lilith is blindfolded and does not shoot tears by herself, items like Technology 2 Technology 2, Tech.5 Tech.5 and Removed in RepentanceTractor Beam Tractor Beam have no effect. However, The Ludovico Technique The Ludovico Technique and Added in RepentanceTractor Beam Tractor Beam still work as they would on any other character.
    • Removed in Repentance Obtaining The Ludovico Technique The Ludovico Technique is necessary to utilize Maw of the Void Maw of the Void to its fullest, as it will allow Lilith to create the damaging black ring around her.
    • Removed in RepentanceCursed Eye Cursed Eye ends up being a powerful item due to this, as it causes Incubus Incubus to fire three tears per shot with no charging, while Lilith doesn't have to worry about getting teleported by accident as she cannot charge up.
  • While other activatable items may have some form of use, it is not advised to permanently trade out the Box of Friends Box of Friends. Without it, Lilith loses what is essentially her greatest strength, as Incubus Incubus shooting in her place is only a positive with its usage.
    • If Lilith dies with an extra life item that changes her to a different character (Ankh Ankh, Lazarus' Rags Lazarus' Rags, Judas' Shadow Judas' Shadow), she will lose both her blindfold and the intrinsic Incubus familiar.
    • Despite this, Lilith's Incubus still counts as an actual item. Be warned as this makes a run with only 19 visible items have the chance to warp to The Void The Void after the Mom Mom fight.
  • Added in Repentance Taking Brimstone Brimstone while having The Ludovico Technique The Ludovico Technique will synergize and become a large controllable ring per incubus. Multiple rings may completely overlap.
  • Added in RepentanceForgotten Lullaby Forgotten Lullaby is effectively a tears up for the Incubus familiar, and can also boost any other familiars Lilith might get.
  • Added in RepentanceSpirit Sword Spirit Sword: The sword is held by the fetus and acts the same way as with other characters.

Item Interactions[]

  • Added in RepentanceBird's Eye Bird's Eye / Added in RepentanceGhost Pepper Ghost Pepper: Flames emerge from Lilith instead of the Incubus.
  • Added in RepentanceBirthright Birthright: All shooting familiars no longer follow behind Lilith. They all group towards Lilith's firing direction instead.
  • Added in Afterbirth †Baby-Bender Baby-Bender affects the Incubus, as it's a familiar, identically to Spoon Bender Spoon Bender.

Ineffective Items[]

These items will not affect Lilith due to her blindfolded condition and certain limitations of Incubus Incubus.

Note: As mentioned above, certain items will apply their normal effects if Lilith obtains The Ludovico Technique The Ludovico Technique.

Unlockable Achievements[]


  • Lilith is the Hebrew name for a figure in Jewish mythology, thought to be derived from early class of female demons.
  • In some cultures, Lilith is the original woman God created before Eve. She refused to become subservient to Adam and left Eden; in others, she is depicted as the bane of humanity when Adam refused her, driving her to curse all of his descendants and targets children under grudge.
  • Cambion Conception is always listed as one of Lilith's starting items, even if it has not been unlocked.
  • Lilith, as well as The Lost The Lost and Bethany Bethany, are the only non-tainted characters whose unlock conditions require a specific character.
  • Removed in Afterbirth †Lilith's starting health is listed as "?" on the character selection screen.
  • Lilith's locked character icon is a locked box with her Incubus on it