Lilith's Incubus familiar copies whatever tears she would fire if she weren't blindfolded. Combined with the Box of Friends, the basic strategy for her is to simply multiply her damage. Powerful tear modifiers such as Polyphemus will become even more deadly if Lilith can create several Incubi.
Mom's Knife gives Incubus a smaller version of the item with the same base range as Isaac; However, Lilith will not get this to use due to her blindfold.
This knife can be used with Incubus to give it contact damage with no danger to Lilith.
With Mom's Knife and Tech X, Incubus can shoot Tech X shots and Mom's Knife incredibly fast for massive damage. Charging doesn't affect Tech X's size or Mom's Knife's throwing distance, making the knife useless in this combo unless used at very short range. This is a very strong combo for Lilith as she already starts with Incubus and can use Box of Friends to multiply her damage.
If Brimstone is taken after Tech X, Incubus will still fire its standard laser rings, not Brimstone rings.
Lilith can use the Epic Fetus while her Incubi still fire what her tears would be without Epic Fetus.
Unless you have a beam weapon (Brimstone/Technology), picking up My Reflection is a bad idea: it will greatly shorten Incubus' range without the possibility to increase it.
Due to her starter item Box of Friends, she strongly benefits from other familiars and familiar enhancers like BFFS!.
Battery items are very useful for Lilith so she can continue to use the Box of Friends.
9 Volt will reduce it to a 3-room ( 2-room) charge allowing it to be used more often.
Car Battery will double the effect of the item, meaning she'll create 2 copies of each familiar per use.
Charged Baby creates batteries or recharges your item by one bar occasionally, and is also duplicated by the Box of Friends. The more the player creates, the more often they will obtain batteries and charges from the increasing number of charged babies.
Heart Containers, healing items, and Heart-generating items (Charm of the Vampire, Humbling Bundle, etc.) indirectly benefit Lilith since her Cambion Conception gives her additional familiars after taking multiple hits. Use a fireplace or Heart Donation Machine to damage yourself multiple times to speed up the familiar-generating process (preferably after killing the boss to not hurt your Devil/Angel Room spawn chances).
Activated Items recharge per-wave in Greed Mode and Boss Rush, allowing Lilith to use the Box of Friends very often. Familiars like The Relic and Little C.H.A.D. could give the player an endless amount of health if used correctly.
Due to this, during Greed mode, it is most effective to stay within the Arena for every wave in order to maximize the amount of familiars you have upon reaching the boss waves.
4.5 Volt replaces the per-wave charging. With only this, compared to no battery items, starting and ending fully charged, it's typically possible to use Box of Friends once or twice more in a full set of Greed Mode waves.
When shooting, keep in mind that Incubus lingers behind you.
One must take heed in duplicating familiars with the Box of Friends. If the player creates too many (easy to achieve in Greed Mode or Boss Rush), when the player steps into another room, all of their minions, including the originals, will despawn. This can be fixed by quitting and reloading the run.
Obtaining The Ludovico Technique is necessary to utilize Maw of the Void to its fullest, as it will allow Lilith to create the damaging black ring around her.
Cursed Eye ends up being a powerful item due to this, as it causes Incubus to fire three tears per shot with no charging, while Lilith doesn't have to worry about getting teleported by accident as she cannot charge up.
While other activatable items may have some form of use, it is not advised to permanently trade out the Box of Friends. Without it, Lilith loses what is essentially her greatest strength, as Incubus shooting in her place is only a positive with its usage.
Lilith's Incubus is intrinsic to her, the same way Azazel's short Brimstone is. It cannot be removed by effects that reroll items, such as the D4. The Incubus can be found as a separate item, and picking it up will grant Lilith a second Incubus familiar.
If Lilith dies with an extra life item that changes her to a different character (Ankh, Lazarus' Rags, Judas' Shadow), she will lose both her blindfold and the intrinsic Incubus familiar.
Despite this, Lilith's Incubus still counts as an actual item. Be warned as this makes a run with only 19 visible items have the chance to warp to The Void after the Mom fight.
Taking Brimstone while having The Ludovico Technique will synergize and become a large controllable ring per incubus. Multiple rings may completely overlap.
Forgotten Lullaby is effectively a tears up for the Incubus familiar, and can also boost any other familiars Lilith might get.
Lilith is the Hebrew name for a figure in Jewish mythology, thought to be derived from early class of female demons.
In some cultures, Lilith is the original woman God created before Eve. She refused to become subservient to Adam and left Eden; in others, she is depicted as the bane of humanity when Adam refused her, driving her to curse all of his descendants and targets children under grudge.
Cambion Conception is always listed as one of Lilith's starting items, even if it has not been unlocked.
Lilith, as well as The Lost and Bethany, are the only non-tainted characters whose unlock conditions require a specific character.
Lilith's starting health is listed as "?" on the character selection screen.
Damage
Tears
Shot Speed
Range
23.75
6.5
Speed
Luck
Pickups
Blindfolded
Box of Friends
Incubus
Cambion Conception
Polyphemus will become even more deadly if Lilith can create several Incubi.
Mom's Knife gives Incubus a smaller version of the item with the same base range as Isaac; However, Lilith will not get this to use due to her blindfold.
Tech X, Incubus can shoot 
Epic Fetus while her Incubi still fire what her tears would be without Epic Fetus.
Brimstone/
Technology), picking up 
My Reflection is a bad idea: it will greatly shorten Incubus' range without the possibility to increase it.
BFFS!.
9 Volt will reduce it to a 3-room (
Car Battery will double the effect of the item, meaning she'll create 2 copies of each familiar per use.
Charged Baby creates batteries or recharges your item by one bar occasionally, and is also duplicated by the 
Charm of the Vampire, 
Humbling Bundle, etc.) indirectly benefit Lilith since her 
The Relic and 
Little C.H.A.D. could give the player an endless amount of health if used correctly.
4.5 Volt replaces the per-wave charging. With only this, compared to no battery items, starting and ending fully charged, it's typically possible to use 
Technology 2, 
Tech.5 and 
Tractor Beam have no effect. However, 
The Ludovico Technique and 
Maw of the Void to its fullest, as it will allow Lilith to create the damaging black ring around her.
Cursed Eye ends up being a powerful item due to this, as it causes 
D4. The 
Ankh, 
Lazarus' Rags, 
Judas' Shadow), she will lose both her blindfold and the intrinsic Incubus familiar.
Forgotten Lullaby is effectively a tears up for the Incubus familiar, and can also boost any other familiars Lilith might get.
Dead Tooth
Loki's Horns
Mom's Eye
Mom's Wig
The Mulligan (The Guppy transformation does work, however)
Dead Eye
Epiphora
Evil Eye
Marked (Stat increases are applied, but the mark does not appear)
Analog Stick (Tears up is applied, but Incubus cannot fire in 360 degrees)
Ghost Pepper
Lead Pencil
Lilith's starting health is listed as "?" on the character selection screen.
The Binding of Isaac: Rebirth 
Achievements
Attributes
Bosses
Cards and Runes
Challenges
Chapters
Characters
Co-op
Items
Item pools
Monsters
Objects
Pickups
Pills
Rooms
Seeds
Transformations
Trinkets
