The Ludovico Technique: The clot's tear floats the same way Isaac's tear does. Additional clots gained from Mom's box, Found Soul, and golden versions of the trinket will have an additional floating tear.
Tractor Beam: Lil Clot's tears travel along the beam regardless of the location of Lil Clot.
When used together with Azazel's Stump, the blood clot familiar sometimes keeps Azazel's properties (flight and short brimstone) for a few rooms after you have transformed back from Azazel into your original character. Found Soul also has this bug.
PC If Isaac has both The Ladder and a form of flight, the clot familiar will be unable to path over any terrain with a ladder on it despite having the ability to fly, resulting in movement desync.