Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Leprosy is an unlockable passive item added in The Binding of Isaac: Afterbirth † (Booster Pack #2).


  • Upon taking damage, Isaac gains a body part as an orbital, which blocks enemy shots and deals 7 damage per tick (35 damage per second) to enemies it comes in contact with.
    • A maximum of three body parts can be active at once.
    • The body parts will be destroyed after dealing 30 ticks of damage and/or blocking 3 shots.
    • The body parts persist between floors.
    • Body parts orbit on the same layer as Blue Flies and Locusts do.


In-game Footage[]


  • The description "You're tearing me apart!" is a reference to the movie The Room (which Edmund has said he is a big fan of), in which Tommy Wiseau famously exclaims "You're tearing me apart, Lisa!".
  • Leprosy was inspired by a Steam Workshop item by Bobby Lashley Fangirl #1.
  • The item used to be misspelled "Leprocy" but was corrected in a later patch.
  • The item is a reference to leprosy, a bacterial disease that damages nerves and can cause extremities to rot in extreme cases.