Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Large Zit is a passive item added in The Binding of Isaac: Afterbirth †.


  • While firing, Isaac has a chance to fire an additional creep shot that deals double damage and leaves a trail of white creep that slows enemies.
    • The chance is not affected by luck.
    • The creep shots are affected by range and shot speed, but don't take on any tear effects.
  • A creep shot will also be fired in a random direction when taking damage.
  • Unlike most creep effects, this creep will affect flying enemies.


  • Brimstone Brimstone: Creep shots will still be fired occasionally while holding the fire button.
  • Dr. Fetus Dr. Fetus: Isaac occasionally fires a creep shot along with a bomb.
  • Epic Fetus Epic Fetus: Isaac will occasionally fire a creep shot while moving crosshair.
  • Ipecac Ipecac: High tear damage from Ipecac is doubled, causing very powerful creep shots.
  • Mom's Knife Mom's Knife: Creep shots will still be fired occasionally while holding the fire button.
  • Monstro's Lung Monstro's Lung: Creep shots will still occasionally fired after or before tear barrage.
  • Polyphemus Polyphemus: High tear damage from Polyphemus is doubled.
  • Technology Technology/Tech.5 Tech.5: Creep shots will occasionally be fired along with lasers.
  • Technology Zero Technology Zero: Creep shots will be connected to other tears via electricity.


In-game Footage[]


  • Large Zit was originally an unofficial item which was supposed to showcase the modding capabilities of Afterbirth+ in the PAX 2016 livestream. However, all items included in the demo were later added to the final game.


PC Normal and hard modes only JPV6 AHEQ

Switch Greedier mode only 1JKG C94H (First Golden Treasure Room)