Binding of Isaac: Rebirth Wiki

Added in Repentance

Knockout Drops is a passive item added in The Binding of Isaac: Repentance.


  • Adds a 10% chance to shoot red fist-shaped tears that deal extreme knockback and cause confusion for 2 seconds.
    • Enemies that are knocked back will take/deal 10 + 2 * (floor - 1) damage too, and knock back any enemies they are knocked into, as well as if they run into a wall/obstacle.
  • The chance to fire fist tears is affected by luck. At base luck (0), the chance is 10%, maxing out at 100% at 9 luck.


  • Bosses are also affected by all of Knockout Drops' effects.
  • Fist tears play a unique punch sound effect when they hit enemies.
  • Knockout Drops can be dangerous in The Beast The Beast battle, as the Ultra Harbingers may get knocked so far off the screen they become hard to damage further and their attacks cannot be seen properly.


  • Aquarius Aquarius: The trail of tears has a chance to knockback enemies.
  • Brimstone Brimstone: Gives the lasers high knockback.
  • Jacob's Ladder Jacob's Ladder: Enemies that are shocked by a knockback tear will also be knocked back.
  • The Ludovico Technique The Ludovico Technique: Hovering tear alternates between a normal tear and a fist.

In-game footage[]



  • Taking this item as Keeper Keeper will give him the expression of Bum-Bo the Brave, and by extension, Bumbino Bumbino.