Key Masters will pay out with either one of these items or the after being given enough keys.
Opens all doors in the current room when activated, including doors which require a key to open and entrances to Secret Rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Summons a controllable ghost that can perform various tasks depending on what it targets.
Creates a new room adjacent to a viable wall, indicated by the outline of a door. These rooms have a chance to be various special rooms.
Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds.
Spawns an attack fly that circles further out than , but closer than Halo of Flies , dealing 75 damage per second.
Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Halo of Flies
Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Adds 2 keys. Chests will drop additional pickups.
Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
???'s Only Friend
Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
Spawns a white attack fly that orbits somewhere between and Distant Admiration , dealing 45 damage per second.
Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return.
Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.
Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
Grants 1 Soul Heart and +1 luck. Spawns 2 Keys.
Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears.
Spawns nine orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
+1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks.